توضیحاتی در مورد کتاب :
در طول دهههای گذشته، پیشرفتهای بزرگی در درک مسیرهای ترمیم DNA سلولی صورت گرفته است. در عین حال، دانش توصیفی فراوانی در مورد بیماری های انسانی انباشته شده است. اکنون، تحقیقات اساسی مکانیسم های ترمیم DNA با تحقیقات بالینی ادغام می شود و عمل مسیرهای ترمیم DNA را در بافت کل ارگانیسم قرار می دهد. چنین رویکرد یکپارچه ای درک مکانیسم های بیماری را امکان پذیر می کند و در بهبود تشخیص و پیشگیری و همچنین طراحی درمان های بهتر بسیار ارزشمند است. این کتاب نقش اصلی ترمیم DNA در سلامت و رفاه انسان را برجسته می کند. بررسی های ارائه شده در اینجا، حاوی توضیحات مفصلی از مسیرهای ترمیم DNA، و همچنین تجزیه و تحلیل تعداد زیادی از شواهد مربوط به ارتباط بین ترمیم آسیب DNA و سلامت انسان است. آنها برای مخاطبان وسیعی، از زیست شناسان مولکولی که بر روی ترمیم DNA در هر سیستم مدلی کار می کنند، گرفته تا محققان پزشکی، مورد علاقه خواهند بود.
فهرست مطالب :
Chapter 1 DNA Repair, Human Diseases and Aging by Vaidehi Krishnan, Baohua Liu and Zhongjun Zhou
Chapter 2 Double Strand Break Signaling in Health and Diseases by Marie-jo Halaby and Razqallah Hakem
Chapter 3 DNA Damage Repair and Cancer: The Role of RAD51 Protein and Its Genetic Variants by Augusto Nogueira, Raquel Catarino and Rui Medeiros
Chapter 4 The Role of Error-Prone Alternative Non-Homologous End-Joining in Genomic Instability in Cancer by Li Li, Carine Robert and Feyruz V. Rassool
Chapter 5 Nucleotide Excision Repair and Cancer by Joost P.M. Melis, Mirjam Luijten, Leon H.F. Mullenders and Harry van Steeg
Chapter 6 Recombinant Viral Vectors for Investigating DNA Damage Responses and Gene Therapy of Xeroderma Pigmentosum by Carolina Quayle, Carlos Frederico Martins Menck and Keronninn Moreno Lima-Bessa
Chapter 7 DNA Damage, Repair and Misrepair in Cancer and in Cancer Therapy by Ana M. Urbano, Leonardo M. R. Ferreira, Joana F. Cerveira, Carlos F. Rodrigues and Maria C. Alpoim
Chapter 8 DNA Repair, Cancer and Cancer Therapy by Mu Wang
Chapter 9 DNA Repair, Cancer and Cancer Therapy - The Current State of Art by Turgay Isbir, Berna Demircan, Deniz Kirac, Burak Dalan and Uzay Gormus
Chapter 10 Application of UV-Induced Unscheduled DNA-Synthesis Measurements in Human Genotoxicological Risk Assessment by Anna Tompa, Jenő Major and Mátyás G. Jakab
Chapter 11 Hypoxia Inhibits DNA Repair to Promote Malignant Progression by L. Eric Huang, Young-Gun Yoo, Minori Koshiji and Kenneth K.W. To
Chapter 12 From the Molecular Biology to the Gene Therapy of a DNA Repair Syndrome: Fanconi Anemia by Paula Río, Susana Navarro and Juan A. Bueren
Chapter 13 Fanconi Anemia/Brca Pathway and Head and Neck Squamous Cell Carcinomas by Shi-Long Lu
Chapter 14 DNA Repair Deficiency Associated with Hematological Neoplasms by Panagiota Economopoulou, Vassiliki Pappa, Sotirios Papageorgiou, John Dervenoulas and Theofanis Economopoulos
Chapter 15 DNA Repair in Acute Myeloid Leukemia and Myelodysplastic Syndromes by Anna Szmigielska-Kaplon and Tadeusz Robak
Chapter 16 Therapeutic Modulation of DNA Damage and Repair Mechanisms in Blood Cells by Haiyan Wang, Shanbao Cai, Eva Tonsing-Carter and Karen E. Pollok
Chapter 17 DNA Repair Perspectives in Thyroid and Breast Cancer: The Role of DNA Repair Polymorphisms by Susana N. Silva, Bruno Costa Gomes, José Rueff and Jorge Francisco Gaspar
Chapter 18 DNA Mismatch Repair (MMR) Genes and Endometrial Cancer by Kenta Masuda, Kouji Banno, Megumi Yanokura, Iori Kisu, Arisa Ueki, Asuka Ono, Yusuke Kobayashi, Hiroyuki Nomura, Akira Hirasawa, Nobuyuki Susumu and Daisuke Aoki
Chapter 19 Human Apurinic/Apyrimidinic Endonuclease is a Novel Drug Target in Cancer by Rachel M. Abbotts, Christina Perry and Srinivasan Madhusudan
Chapter 20 Disruption of Protein–DNA Interactions: An Opportunity for Cancer Chemotherapy by Tracy M. Neher, Wei Huang, Jian-Ting Zhang and John J. Turchi
Chapter 21 Pharmacogenomic Approach of Telomerase in Cancer: Importance of End Zone Variability by R. Catarino, A. Nogueira, A. Coelho and R. Medeiros
Chapter 22 Differential Effects of the G-Quadruplex Ligand 360A in Human Normal and Cancer Cells by Christine Granotier and François D. Boussin
Chapter 23 Pharmacogenetics of Cancer and DNA Repair Enzymes by Tahar van der Straaten, Leon Mullenders and Henk-Jan Guchelaar
Chapter 24 Involvement of Histone PTMs in DNA Repair Processes in Relation to Age-Associated Neurodegenerative Disease by Chunmei Wang, Erxu Pi, Qinglei Zhan and Sai-ming Ngai
Chapter 25 Transcriptional Functions of DNA Repair Proteins Involved in Premature Aging by Robin Assfalg and Sebastian Iben
Chapter 26 DNA Damage and mRNA Levels of DNA Base Excision Repair Enzymes Following H2O2 Challenge at Different Temperatures by Kyungmi Min and Susan E. Ebeler
Chapter 27 Relationship Between DNA Damage and Energy Metabolism: Evidence from DNA Repair Deficiency Syndromes by Sarah Vose and James Mitchell
Chapter 28 The Role of DNA Repair Pathways in Adeno-Associated Virus Infection and Viral Genome Replication / Recombination / Integration by Kei Adachi and Hiroyuki Nakai
Chapter 29 Integration of the DNA Damage Response with Innate Immune Pathways by Gordon M. Xiong and Stephan Gasser
Chapter 30 Non-Steroidal Anti-Inflammatory Drugs, DNA Repair and Cancer by Harpreet K. Dibra, Chris J. Perry and Iain D. Nicholl
Chapter 31 Inhibition of DNA Polymerase λ, a DNA Repair Enzyme, and Anti-Inflammation: Chemical Knockout Analysis for DNA Polymerase λ Using Curcumin Derivatives by Yoshiyuki Mizushina, Masayuki Nishida, Takeshi Azuma and Masaru Yoshida
توضیحاتی در مورد کتاب به زبان اصلی :
Over the past decades, great advances have been made in understanding the cellular DNA repair pathways. At the same time, a wealth of descriptive knowledge of human diseases has been accumulated. Now, the basic research of the mechanisms of DNA repair is merging with clinical research, placing the action of the DNA repair pathways in the context of the whole organism. Such integrative approach enables understanding of the disease mechanisms and is invaluable in improving diagnostics and prevention, as well as designing better therapies. This book highlights the central role of DNA repair in human health and well-being. The reviews presented here, contain detailed descriptions of DNA repair pathways, as well as analysis of a large body of evidence addressing links between DNA damage repair and human health. They will be of interest to a broad audience, from molecular biologists working on DNA repair in any model system, to medical researchers.