دانلود کتاب Advances in Research on Neurodegeneration

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Front Matter....Pages I-VIII
The L -DOPA story revisited. Further surprises to be expected?....Pages 1-20
The enigma of cell death in neurodegenerative disorders....Pages 21-36
Impaired iron homeostasis in Parkinson’s disease....Pages 37-58
The molecular mechanism of dopamine-induced apoptosis: identification and characterization of genes that mediate dopamine toxicity....Pages 59-76
Glyceraldehyde-3-phosphate dehydrogenase in neurodegeneration and apoptosis signaling....Pages 77-100
Importance of familial Parkinson’s disease and parkinsonism to the understanding of nigral degeneration in sporadic Parkinson’s disease....Pages 101-116
cDNA microarray to study gene expression of dopaminergic neurodegeneration and neuroprotection in MPTP and 6-hydroxydopamine models: implications for idiopathic Parkinson’s disease....Pages 117-124
Monitoring neuroprotection and restorative therapies in Parkinson’s disease with PET....Pages 125-137
Common properties for propargylamines of enhancing superoxide dismutase and catalase activities in the dopaminergic system in the rat: implications for the life prolonging effect of (–)deprenyl....Pages 139-156
TV3326, a novel neuroprotective drug with cholinesterase and monoamine oxidase inhibitory activities for the treatment of Alzheimer’s disease....Pages 157-169
Neurotoxins induce apoptosis in dopamine neurons: protection by N-propargylamine-1(R)- and (S)-aminoindan, rasagiline and TV1022....Pages 171-186
Homocysteine and alcoholism....Pages 187-196
Neurorescuing effects of the GAPDH ligand CGP 3466B....Pages 197-214
The neuroprotective effects of CGP 3466B in the best in vivo model of Parkinson’s disease, the bilaterally MPTP-treated rhesus monkey....Pages 215-225
Neurotrophic effects of central nicotinic receptor activation....Pages 227-245
Regulation of neuronal cell death and differentiation by NGF and IAP family members....Pages 247-259
Insulin-like growth factor-1 (IGF-1): a neuroprotective trophic factor acting via the Akt kinase pathway....Pages 261-272
GDF-15/MIC-1 a novel member of the TGF-ß superfamily....Pages 273-276
Changes in cytokines and neurotrophins in Parkinson’s disease....Pages 277-290
Psychiatric complications in Parkinson’s disease....Pages 291-302
Dementia with Lewy bodies: prevalence, clinical spectrum and natural history....Pages 303-314
Neuronal degeneration and reorganization: a mutual principle in pathological and in healthy interactions of limbic and prefrontal circuits....Pages 315-333
Depression in alpha-synucleinopathies: prevalence, pathophysiology and treatment....Pages 335-343
The serotonin transporter in Alzheimer’s and Parkinson’s disease....Pages 345-350
Immunopathogenic and clinical relevance of antibodies against myelin oligodendrocyte glycoprotein (MOG) in Multiple Sclerosis....Pages 351-360
Lessons from studies of antigen-specific T cell responses in Multiple Sclerosis....Pages 361-373
Glutamate excitotoxicity — a mechanism for axonal damage and oligodendrocyte death in Multiple Sclerosis?....Pages 375-385
Evidence for enhanced neuro-inflammatory processes in neurodegenerative diseases and the action of nitrones as potential therapeutics....Pages 387-414
Back Matter....Pages 415-424