دانلود کتاب Aging oxidative stress and dietary antioxidants

فهرست مطالب :

Front Cover......Page 1
Aging: Oxidative Stress and Dietary Antioxidants......Page 4
Copyright......Page 5
Contents......Page 6
Contributors......Page 12
Preface......Page 16
Section 1: Oxidative stress and aging......Page 18
microRNA......Page 20
miR-200c and oxidative stress......Page 22
miR-200c induces apoptosis and senescence via ZEB1 inhibition......Page 23
miR-200c oxidative stress and endothelial dysfunction......Page 24
Applications to other diseases or conditions......Page 25
References......Page 26
CR in animals......Page 28
The AMPK pathway......Page 29
CR in humans......Page 30
CALERIE-2 study......Page 31
Trials on other modified CR and other modules mimicking CR-induced beneficial signaling......Page 32
References......Page 33
Further reading......Page 35
Introduction......Page 36
Physiology of the aging cardiovascular system......Page 38
The molecular basis of oxidative stress as applied to the cardiovascular system......Page 40
The cardiovascular system and SIR2 proteins......Page 41
The cardiovascular system and FOXO proteins......Page 42
Mammalian target of rapamycin (mTOR)......Page 43
Oxidative stress and mCLK......Page 44
Oxidative stress and catalase......Page 45
Oxidative stress and PIT1/PROP1......Page 46
Recent advances in cardiovascular disease, aging and oxidative stress......Page 47
Applications to other diseases and conditions......Page 48
References......Page 49
Further reading......Page 52
Introduction......Page 54
Evidence for age-associated loss of mitochondrial bioenergetics in liver......Page 55
Oxidative stress and antioxidant responses in liver aging......Page 56
Oxidative damage to the nuclear and mitochondrial genomes in liver aging......Page 57
Mitochondrial dysfunction and liver-associated disease......Page 59
Summary points......Page 61
References......Page 62
Introduction......Page 64
Treacherous role of oxygen and nitrogen molecule in PD......Page 65
RONS-mediated biomolecular destruction in PD......Page 68
Counteractive mechanism of antioxidants in PD......Page 71
Neuroinflammation in PD......Page 73
Summary points......Page 74
References......Page 75
Further reading......Page 76
Basic biology of bone......Page 78
Aging and bone: Role of oxidative stress......Page 79
Osteoblasts......Page 80
Bone marrow mesenchymal stem cells......Page 81
Osteocytes......Page 82
References......Page 86
Introduction......Page 90
Chondrocytes and senescence......Page 91
Chondrocytes and oxidative stress......Page 93
Chondrocytes and pro- and antioxidant agents......Page 94
Mediterranean nutrients: Protective or risk factors?......Page 95
Application to other diseases......Page 96
References......Page 97
Introduction......Page 100
The concept of oxygen toxicity and free radicals......Page 101
Sources of free radicals in arthritis......Page 102
Oxidative stress in arthritis......Page 103
Free radical-mediated biomolecular deterioration in arthritis......Page 104
Alteration in antioxidant defense system in arthritis......Page 106
Oxidative stress and inflammation in arthritis......Page 108
References......Page 109
The aging muscle and sarcopenia......Page 112
Changes in muscle structure......Page 113
Reactive species and redox signaling in aging......Page 114
Redox signaling in skeletal muscle......Page 115
Redox alterations and sarcopenia......Page 116
Applications to other diseases or conditions......Page 117
References......Page 118
Introduction......Page 122
Physical exercise, oxidative stress, and blood pressure control......Page 123
Oxidative stress and anaerobic exercise......Page 125
References......Page 126
Introduction......Page 130
Senescence enhances free radical generation......Page 131
Involvement of other biomolecules in senescence......Page 132
Evidence linking senescence, apoptosis, and oxidative stress in fertility......Page 134
Senescence exacerbates apoptosis......Page 135
Senescence alters sex hormone levels......Page 136
Senescence and ovarian function......Page 137
Applications to other diseases......Page 138
References......Page 139
Menopausal symptoms......Page 142
Oxidative stress, blood antioxidant status, and menopausal symptoms......Page 143
Whole antioxidant-rich diets and menopausal symptoms......Page 144
Vitamin E......Page 145
Antioxidants and minerals......Page 146
Resveratrol......Page 147
References......Page 148
Section 2: Antioxidants and aging......Page 152
Oxidative stress......Page 154
Vitamin E......Page 155
Other vitamins......Page 156
Summary points......Page 160
References......Page 161
Role of estrogen in oxidative stress and antioxidant defense in elderly women......Page 162
Role of telomere length in oxidative stress and antioxidant defense in elderly women......Page 163
Dietary antioxidant therapies in elderly women......Page 164
Role of exercise on oxidative stress and antioxidant status of elderly women......Page 167
Applications to other diseases or conditions......Page 168
References......Page 169
Oxidative stress and reactive oxygen species......Page 172
Antioxidant properties of caffeine and its analogs......Page 173
Caffeine and its analogs as adenosine receptors antagonists......Page 174
Caffeine and its analogs as monoamine oxidase inhibitors......Page 175
Caffeine and its analogs in neurodegenerative disease......Page 176
Anticancer properties of caffeine and its analogs......Page 177
References......Page 179
Coenzyme Q10......Page 182
Levels and distribution of coenzyme Q10 in the human organism......Page 183
Uptake and distribution of CoQ10......Page 184
CoQ10 and endothelial function......Page 185
Conclusions......Page 186
References......Page 187
Bone biology......Page 190
Regulation of bone remodeling......Page 191
Oxidative stress and bone health......Page 192
Coenzyme Q10 (CoQ10), oxidative stress, and bone metabolism......Page 193
What happens during aging?......Page 195
Has diet any modulatory role in CoQ10 effect on bone health during aging?......Page 197
References......Page 198
Introduction......Page 200
CoQ10 and longevity, the intriguing role of Clk-1/COQ7......Page 201
CoQ10 levels and longevity in humans......Page 203
CoQ1010 supplementation and longevity......Page 204
Applications to other diseases or conditions......Page 205
References......Page 206
Background......Page 210
Chemical composition of saffron......Page 211
Safety assessments of saffron and its main ingredients......Page 212
Experimental studies......Page 213
Clinical studies......Page 214
References......Page 216
Introduction......Page 218
Pharmacodynamics of γ-oryzanol......Page 219
γ-Oryzanol as a Nrf2-inducer......Page 220
Antioxidant effects of γ-oryzanol in age-related diseases......Page 221
γ-Oryzanol and inflammation......Page 222
References......Page 223
Introduction......Page 226
Plant antioxidants......Page 227
Specificities of plant use......Page 228
Nonkavalactones......Page 229
Issue of plant antioxidants in aging or longevity and its evidence......Page 231
Okinawa plants, their antioxidants and association with longevity......Page 232
Antipancreatic lipase......Page 233
Okinawa longevity......Page 234
Caloric and dietary restriction......Page 235
Causality gap under discussion between antioxidant plants and longevity in Okinawa......Page 236
IntroductionNature-derived products including plants such as herbs not only are part of human life as medicines and food......Page 237
References......Page 238
Oxidative stress and antioxidants......Page 240
Prevalence of osteoporosis......Page 241
Studies on lycopene in osteoblasts and osteoclasts......Page 242
Epidemiological studies on lycopene......Page 243
Clinical intervention studies on lycopene......Page 244
Acknowledgments......Page 246
References......Page 247
Lipid peroxidation......Page 250
Protein damage......Page 251
Antiaging effects of medicinal plants......Page 252
Some of the major antioxidant enzymes and nonenzymes of medicinal plants and their proposed mechanism of action......Page 254
Some important points to be noted......Page 255
References......Page 257
Introduction......Page 260
How free radicals are formed......Page 261
Some oxidative stress-related facts about the brain......Page 263
Where do free radicals come from in the Alzheimer\'s disease brain?......Page 264
How does melatonin scavenge free radicals?......Page 267
Breaking the cycle neuroinflammationoxidative stress......Page 269
Conclusions......Page 270
References......Page 271
Mechanisms of free radical production......Page 276
Oxidative stress and aging......Page 277
Chemical composition and biological activity......Page 278
Murici\'s application to other diseases and conditions......Page 279
Summary points......Page 280
References......Page 281
Introduction......Page 284
Cuscuta chinensis (Convolvulaceae, Fig. 4)......Page 285
Nephelium lappaceum (Sapindaceae, Fig. 8)......Page 286
Terminalia chebula (Combretaceae, Fig. 12)......Page 287
Discussion......Page 288
References......Page 289
Cellular senescence in the body......Page 292
Ophiopogonis Radix......Page 293
Antiinflammatory effects of Ophiopogonis Radix on senescent NHDFS19......Page 294
Conclusions......Page 296
Summary points......Page 298
References......Page 299
Oxidative stress and skin aging......Page 300
Preparation of antioxidative passion fruit seed extract by reflux and fractionation......Page 301
Conclusion......Page 302
References......Page 304
Nutritional importance of common bean......Page 306
Occurrence of bioactive compounds in common bean......Page 307
Polyphenols as important antioxidant compounds in common bean......Page 308
Common bean and prevention of aging processes......Page 309
Conclusions......Page 310
References......Page 311
Introduction......Page 314
Diabetes and renal cell aging......Page 315
Endothelin-1 (ET-1)......Page 316
Beta-galactosidase as a marker of senescent cells......Page 317
References......Page 318
Minerals in rambutan peel......Page 320
Antioxidant activity of various parts of rambutan fruits......Page 321
Conclusion......Page 322
References......Page 323
Skeletal muscle fatigue......Page 326
ROS and muscle fatigue......Page 327
Resveratrol is a potent antioxidant with multiple functions......Page 328
Resveratrol and exercise in animal models......Page 329
Resveratrol and fatigue, the underlying mechanisms......Page 330
References......Page 332
Aging and the protective role of SIRT1......Page 336
Polyphenols against brain aging: Resveratrol as prototypical example......Page 338
Challenges on resveratrol application in the prevention of neurodegeneration......Page 340
References......Page 341
Human aging and its consequences......Page 344
Oxidative stress and age-related disease......Page 345
Potential role of vegetarian diets for lowering risk of disease and increasing health span......Page 347
Some evidence......Page 348
Questions of molecular connections and research needs......Page 350
References......Page 351
The role of vitamin D on oxidative stress......Page 354
Vitamin D in the prevention of dementia......Page 355
Vitamin D supplementation and cognitive health......Page 358
References......Page 359
Discovery of zinc deficiency in humans......Page 362
Severe deficiency of zinc......Page 363
Zinc deficiency in the elderly......Page 364
Effect of zinc supplementation in the elderly: Cell-mediated immunity and incidence of infection......Page 365
Effect of zinc supplementation on oxidative stress and inflammatory cytokines in the elderly......Page 369
Zinc trials in AMD......Page 371
Proposed concept of mechanism of zinc action as an antioxidant and antiinflammatory agent......Page 372
Mechanism of zinc action as an antioxidant......Page 373
Zinc as a molecular signal regulating oxidative stress and chronic inflammation......Page 374
Metallothionein......Page 375
References......Page 376
Senescence-accelerated mouse: Animal model of aging......Page 380
Production of neuronal NO by NO synthase......Page 381
Changes in antioxidant defense systems of SAM10 in aging......Page 382
References......Page 383
Introduction......Page 386
Resources......Page 387
Summary points......Page 389
References......Page 390
Index......Page 392
Back Cover......Page 400