دانلود کتاب Analysis and purification methods in combinatorial chemistry

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Analysis and Puri.cation Methods in Combinatorial Chemistry......Page 4
Copyright......Page 5
CONTENTS......Page 6
PREFACE......Page 10
CONTRIBUTORS......Page 12
PART I ANALYSIS FOR FEASIBILITY AND OPTIMIZATION OF LIBRARY SYNTHESIS......Page 16
CHAPTER 1 QUANTITATIVE ANALYSIS IN ORGANIC SYNTHESIS WITH NMR SPECTROSCOPY Laura H. Lucas and Cynthia K. Larive......Page 18
CHAPTER 2 19F GEL-PHASE NMR SPECTROSCOPY FOR REACTION MONITORING AND QUANTIFICATION OF RESIN LOADING Joseph M. Salvino......Page 52
CHAPTER 3 THE APPLICATION OF SINGLE-BEAD FTIR AND COLOR TEST FOR REACTION MONITORING AND BUILDING BLOCK VALIDATION IN COMBINATORIAL LIBRARY SYNTHESIS Jason J. Cournoyer, Clinton A. Krueger, Janice V.Wade, and Bing Yan......Page 68
CHAPTER 4 HR-MAS NMR ANALYSIS OF COMPOUNDS ATTACHED TO POLYMER SUPPORTS Meritxell Guinó and Yolanda R. de Miguel......Page 86
CHAPTER 5 MULTIVARIATE TOOLS FOR REAL-TIME MONITORING AND OPTIMIZATION OF COMBINATORIAL MATERIALS AND PROCESS CONDITIONS Radislav A. Potyrailo, Ronald J. Wroczynski, John P. Lemmon,William P. Flanagan, and Oltea P. Siclovan......Page 102
CHAPTER 6 MASS SPECTROMETRY AND SOLUBLE POLYMERIC SUPPORT Christine Enjalbal, Frederic Lamaty, Jean Martinez, and Jean-Louis Aubagnac......Page 140
PART II HIGH-THROUGHPUT ANALYSIS FOR LIBRARY QUALITY CONTROL......Page 152
CHAPTER 7 HIGH-THROUGHPUT NMR TECHNIQUES FOR COMBINATORIAL CHEMICAL LIBRARY ANALYSIS Ting Hou and Daniel Raftery......Page 154
CHAPTER 8 MICELLAR ELECTROKINETIC CHROMATOGRAPHY AS A TOOL FOR COMBINATORIAL CHEMISTRY ANALYSIS: THEORY AND APPLICATIONS Peter J. Simms......Page 190
CHAPTER 9 CHARACTERIZATION OF SPLIT-POOL ENCODED COMBINATORIAL LIBRARIES Jing Jim Zhang and William L. Fitch......Page 224
PART III HIGH-THROUGHPUT PURIFICATION TO IMPROVE LIBRARY QUALITY......Page 268
CHAPTER 10 STRATEGIES AND METHODS FOR PURIFYING ORGANIC COMPOUNDS AND COMBINATORIAL LIBRARIES Jiang Zhao, Lu Zhang, and Bing Yan......Page 270
CHAPTER 11 HIGH-THROUGHPUT PURIFICATION: TRIAGE AND OPTIMIZATION Jill Hochlowski......Page 296
CHAPTER 12 PARALLEL HPLC IN HIGH THROUGHPUT ANALYSIS AND PURIFICATION Ralf God and Holger Gumm......Page 322
PART IV ANALYSIS FOR COMPOUND STABILITY AND DRUGABILITY......Page 336
CHAPTER 13 ORGANIC COMPOUND STABILITY IN LARGE, DIVERSE PHARMACEUTICAL SCREENING COLLECTION Kenneth L. Morand and Xueheng Cheng......Page 338
CHAPTER 14 QUARTZ CRYSTAL MICROBALANCE IN BIOMOLECULAR RECOGNITION Ming-Chung Tseng, I-Nan Chang, and Yen-Ho Chu......Page 366
CHAPTER 15 HIGH-THROUGHPUT PHYSICOCHEMICA L PROFILING: POTENTIAL AND LIMITATIONS Bernard Faller......Page 384
CHAPTER 16 SOLUBILITY IN THE DESIGN OF COMBINATORIAL LIBRARIES Christopher Lipinski......Page 422
CHAPTER 17 HIGH-THROUGHPUT DETERMINATION OF LOGDVALUES BY LC/MS METHOD Jenny D. Villena, Ken Wlasichuk, Donald E. Schmidt Jr., and James J. Bao......Page 450
INDEX......Page 472
CHEMICAL ANALYSIS......Page 476