دانلود کتاب Animals in Scientific Research: An Effective Substitute for Man?: Proceedings of a Symposium held in April 1982 under the auspices of the Humane Research Trust

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Front Matter....Pages i-vii
Front Matter....Pages 1-1
Introduction....Pages 3-5
A more scientific approach to the safety evaluation of chemicals....Pages 7-28
The use of short term tests to detect the carcinogenic and mutagenic potential of environmental chemicals....Pages 29-45
The design and use of in vitro toxicity tests....Pages 47-68
Drug metabolism and the safety evaluation of drugs and chemicals....Pages 69-79
A review of the value of isolated hepatocyte systems in xenobiotic metabolism and toxicity studies....Pages 81-90
Isolated human cellular models in clinical pharmacological studies....Pages 91-96
In vitro systems in the study of osteoarthritis....Pages 97-107
Uses and limitations of tissue culture in drug testing....Pages 109-118
Testing for delayed effects on development and differentiation: Some open questions....Pages 119-141
Front Matter....Pages 143-143
Introduction....Pages 145-146
Monitoring human and animal intrauterine development with non invasive methods and perfecting in vitro placental perfusion techniques for toxicologic and teratologic experiments....Pages 147-160
The role of mathematical models in biomedical research....Pages 161-177
Biocrystallography....Pages 179-201
Comparative medicine....Pages 203-209
Legislating against cruelty....Pages 211-220