دانلود کتاب Basic Science for Core Medical Training and the MRCP

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Cover Untitled Title Page Copyright Foreword Preface Acknowledgements Dedication Contents Contributors Abbreviations 1 Genetics 2 Cellular, molecular, and membrane biology 3 Biochemistry and metabolism 4 Immunology 5 Infectious diseases 6 Statistics and epidemiology 7 Haematology 8 Clinical pharmacology Principles of drug action Receptors Ligand binding and responses Fig. 8.1A Ligand binding. (a) Law of mass action. (b) The relationship between agonist concentration and receptor occupancy foran idealized agonist. This relationship is specific for a given drug and receptors in a particular tissue. Fig. 8.1B Log concentration response curves for idealizedexamples of full (A and B) and partial (C) agonists. Antagonists Fig. 8.2A Competitive antagonism and dose ratio (DR) forseveral concentrations (1–100nM) of an idealized competitiveantagonist. Fig. 8.2B Schild equation and plot to establish thedissociation constant (KD) for the competitive antagonist(B) shown in Figure 8.2A. Pharmacokinetics and monitoring drug therapy Administration and absorption Distribution Table 8.1 Advantages and disadvantages of different routes of administration of pharmacological agents Metabolism and excretion Plasma kinetics Fig. 8.4 An example of the plasmaconcentration profile for repeated oral drugdosing (1-h intervals) of a drug with a halflifeof ∼30min. Note how repeated dosesprogressively increase the duration of theeffective periods until steady state is reached. Table 8.2 Inhibitors and inducers of different cytochrome P450 sub-types Mechanisms of drug interactions Therapeutics in particular conditions The elderly Pregnancy and breastfeeding Renal failure Hepatic failure Common overdoses Paracetamol Tricyclic antidepressants Salicylate Ethylene glycol Ecstasy (MDMA) Digoxin Multiple choice questions 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 9 Rheumatology 10 Cardiology 11 Respiratory medicine 12 Neurology 13 Psychiatry 14 Gastroenterology 15 Endocrinology 16 Nephrology Anatomy Physiology Structural features of nephron segmentsand their functional roles Fig. 16.4 Diagrammatic representation of the filtration barrier in the glomerulus and the hydrodynamicforces that determine the rate of ultrafiltration. Fig. 16.5 The ultrastructure of the cells that constitute a nephron. Fig. 16.6 Schematic representation of bicarbonate reabsorption in the proximal tubule. Fig. 16.7 Schematic representation of the countercurrent multiplier of the renal medulla. Pharmacology Table 16.1 Diuretic drugs Loop diuretics Thiazaide diuretics Potassium-sparing diuretics Osmotic diuretics Drug-induced renal reactions Table 16.2 Drug-induced renal reactions Multiple choice questions 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 17 Dermatology Appendix: Answers to multiple choice questions Index