دانلود کتاب Biochemical pharmacology

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Content: Biochemical Pharmacology
Contents
Preface
Acknowledgments
1 Introduction
1.1 Origin and preparation of drugs
1.2 Drugs and drug targets
1.3 Drug molecules may or may not resemble the physiological ligands of their receptors
1.4 Strategies of drug discovery and development
References
2 Pharmacodynamics
2.1 Molecular features of drug-receptor interaction
2.2 Theory of drug-receptor binding
2.3 Dose-effect relationships in signaling cascades
2.4 Potency and efficacy
2.5 Beneficial and toxic drug effects
2.6 Appendix
Study questions
References
3 Pharmacokinetics. 3.1 Anatomical barriers to drug transport3.2 Solute transport across cell membranes
3.3 Drug application
3.4 Drug distribution
3.5 Drug elimination via the kidneys
3.6 Quantitative experimental methods in pharmacokinetics
Study questions
References
4 Drug metabolism
4.1 Overview: Possible functional outcomes of drug metabolism
4.2 Phase I and phase II reactions
4.3 Cytochrome P450
4.4 Reductive drug metabolism
4.5 Conjugation reactions
4.6 Enzyme induction
4.7 Metabolism-related toxicity as a therapeutic target
Study questions
References
5 G protein-coupled receptors. 5.1 Overview5.2 GPCR structure
5.3 Structural GPCR families
5.4 Activation of GPCRs
5.5 GPCR dimerization and oligomerization
5.6 G proteins
5.7 GPCR phosphorylation, endocytosis, and G protein-independent signaling
5.8 Appendix
Study questions
References
6 Pharmacology of cell excitation
6.1 Ions, pumps, and channels
6.2 ATP-driven active ion transport
6.3 Voltage-gated channels and the action potential
6.4 Channels controlled by intracellular ligands
6.5 Transient receptor potential (TRP) channels
6.6 Voltage-gated channels of nerve cells as drug targets. 6.7 Synaptic transmission6.8 Pharmacology of individual transmitters
6.9 Appendix
Study questions
References
7 Hormones
7.1 Hormone receptors
7.2 The hypothalamus and the pituitary gland
7.3 Thyroid gland hormones
7.4 Steroid hormones
7.5 Endocrine control of bone mineralization
Study questions
References
8 Pharmacology of nitric oxide
8.1 Characterization of nitric oxide as a biological signaling molecule
8.2 Nitric oxide synthase and its isoforms
8.3 Biochemical mechanisms of NO signaling
8.4 The biological function of iNOS
8.5 NO-releasing drugs
8.6 NOS inhibitors. 8.7 Phosphodiesterase inhibitorsStudy questions
References
9 Eicosanoid mediators and related drugs
9.1 Biosynthesis of eicosanoids
9.2 The cyclooxygenase reaction
9.3 Cyclooxygenase isoforms and inhibitors
9.4 Phospholipase A2 inhibitors
9.5 Derivatives of prostaglandin H2 and related drugs
9.6 Lipoxygenases, leukotrienes, and related drugs
9.7 Eicosanoids synthesized by cytochrome P450
9.8 Endocannabinoids and related drugs
9.9 The role of polyunsaturated fatty acids in eicosanoid signaling
Study questions
References
10 Intermediate metabolism, diabetes and atherosclerosis.