دانلود کتاب Bioinformatics for Glycobiology and Glycomics: An Introduction

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Bioinformatics for Glycobiology\nand Glycomics......Page 5
Contents......Page 7
List of Contributors......Page 11
Preface......Page 17
Section 1: Introduction......Page 25
1. Glycobiology, Glycomics and (Bio)Informatics......Page 27
Section 2: Carbohydrate Structures......Page 45
2. Introduction to Carbohydrate Structure and Diversity......Page 47
3. Digital Representations of Oligo- and Polysaccharides......Page 73
4. Evolutionary Considerations in Studying the Sialome: Sialic Acids and the Host–Pathogen Interface\n......Page 93
Section 3: Carbohydrate-active Enzymes and Glycosylation......Page 113
5. Carbohydrate-active Enzymes Database: Principles and Classification of Glycosyltransferases......Page 115
6. Other Databases Providing Glycoenzyme Data......Page 143
7. Bioinformatics Analysis of Glycan Structures from a Genomic Perspective......Page 149
8. Glycosylation of Proteins......Page 167
9. Prediction of Glycosylation Sites in Proteins......Page 187
Section 4: Experimental Methods – Bioinformatic Requirements......Page 217
10. Experimental Methods for the Analysis of Glycans and Their Bioinformatics Requirements......Page 219
11. Analysis of N- and O-Glycans of Glycoproteins by HPLC Technology......Page 227
12. Glycomic Mass Spectrometric Analysis and Data Interpretation Tools......Page 247
13. Software Tools for Semi-automatic Interpretation of Mass Spectra of Glycans......Page 281
14. Informatics Concepts to Decode Structure-Function Relationships of Glycosaminoglycans......Page 293
15. NMR Databases and Tools for Automatic Interpretation of Spectra of Carbohydrates......Page 319
16. Automatic Spectrum Interpretation Based on Increment Rules: CASPER......Page 335
17. Interpretation of 13C NMR Spectra by Artificial Neural Network Techniques (NeuroCarb)......Page 345
Section 5: 3D Structures of Complex Carbohydrates......Page 359
18. Conformational Analysis of Carbohydrates – A Historical Overview......Page 361
19. Predicting Carbohydrate 3D Structures Using Theoretical Methods......Page 383
20. Synergy of Computational and Experimental Methods in Carbohydrate 3D Structure Determination and Validation......Page 413
Section 6: Protein–Carbohydrate Interaction......Page 437
21. Structural Features of Lectins and Their Binding Sites......Page 439
22. Statistical Analysis of Protein–Carbohydrate Complexes Contained in the PDB......Page 457
Section 7: Appendices......Page 471
Appendix 1: List of Available Websites......Page 473
Appendix 2: Glossary......Page 477
Index......Page 485
Color Plates......Page 497