دانلود کتاب Blood Science: Principles and Pathology

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Title Page
Copyright Page
Dedication Page
Preface to the Second Edition
Acknowledgements
About the Companion Website
CHAPTER 1: Introduction to Blood Science
1.1 What is Blood Science?
1.2 Clinical Biochemistry
1.3 Blood Transfusion
1.4 Genetics
1.5 Haematology
1.6 Immunology
1.7 The Role of Blood Science in Modern Healthcare
1.8 What this Book will Achieve
Summary
Further Reading
Websites
CHAPTER 2: Analytical Techniques in Blood Science
2.1 Venepuncture
2.2 Anticoagulants
2.3 Sample Identification and Tracking
2.4 Technical and Analytical Confidence
2.5 Major Techniques
2.6 Molecular Genetics
2.7 Point of Care Testing
2.8 Health and Safety in the Laboratory
2.9 Case Studies
Summary
Further Reading
Websites
CHAPTER 3: The Physiology of the Red Blood Cell
3.1 Introduction
3.2 The Development of Blood Cells
3.3 Erythropoiesis
3.4 The Red Cell Membrane
3.5 The Cytoplasm of the Red Cell
3.6 Oxygen Transport
3.7 Recycling the Red Cell
3.8 Red Cell Indices in the Full Blood Count
3.9 Morphology of the Red Cell
Summary
Further Reading
Website
CHAPTER 4: The Pathology of the Red Blood Cell
4.1 Introduction: Diseases of Red Cells
4.2 Anaemia Resulting from Attack on, or Stress to, the Bone Marrow
4.3 Anaemia Due to Micronutrient Deficiency
4.4 Intrinsic Defects in the Red Cell
4.5 External Factors Acting on Healthy Cells
4.6 Erythrocytosis and Polycythaemia
4.7 Inclusion Bodies
4.8 Molecular Genetics and Red Cell Disease
4.9 Case Studies
Summary
Further Reading
Websites
CHAPTER 5: White Blood Cells in Health and Disease
5.1 Introduction
5.2 Leukopoiesis
5.3 Neutrophils
5.4 Lymphocytes
5.5 Monocytes
5.6 Eosinophils
5.7 Basophils
5.8 Leukocytes in Action
5.9 White Cells in Clinical Medicine
5.10 Case Studies
Summary
Further Reading
CHAPTER 6: White Blood Cell Malignancy
6.1 The Genetic Basis of Leukocyte Malignancy
6.2 Tissue Techniques in Haemato‐oncology
6.3 Leukaemia
6.4 Lymphoma
6.5 Myeloma and Related Conditions
6.6 Myelofibrosis and Myelodysplasia
6.7 Non‐coding RNAs
6.8 Case Studies
Summary
Further Reading
CHAPTER 7: The Physiology and Pathology of Haemostasis
Virchow’s Triad
7.1 The Blood Vessel Wall
7.2 Platelets
7.3 The Coagulation Pathway
7.4 Haemostasis as the Balance Between Thrombus Formation and Removal
7.5 The Haemostasis Laboratory
7.6 The Pathology of Thrombosis
7.7 Case Study
Summary
Further Reading
CHAPTER 8: The Diagnosis and Management of Disorders of Haemostasis
8.1 Thrombosis 1: Overactive Platelets and Thrombocytosis
8.2 Thrombosis 2: Overactive Coagulation
8.3 Haemorrhage 1: Platelet Underactivity and Thrombocytopenia
8.4 Haemorrhage 2: Coagulation Underactivity
8.5 Disseminated Intravascular Coagulation (DIC)
8.6 Molecular Genetics in Haemostasis
8.7 Case Studies
Summary
Further Reading
Websites
CHAPTER 9: Immunopathology
9.1 Introduction
9.2 Immunopathology 1: Immunodeficiency
9.3 Immunopathology 2: Hypersensitivity
9.4 Immunopathology 3: Autoimmune Disease
9.5 Immunotherapy
9.6 The Immunology Laboratory
9.7 Case Studies
Summary
Further Reading
Websites
CHAPTER 10: Immunogenetics and Histocompatibility
10.1 The Genetics of Antigen Recognition
10.2 Human Leucocyte Antigens (HLA)
10.3 Mechanisms ofLymphocyte Activation
10.4 Transplantation
10.5 Autoimmunity and HLA
Summary
Further Reading
Websites
CHAPTER 11: Blood Transfusion
What Can Be Transfused?
The Basis of Transfusion Science
11.1 Blood Collection and Processing
11.2 Blood Groups
11.3 Laboratory Practice of Blood Transfusion
11.4 Clinical Practice of Blood Transfusion
11.5 Hazards of Blood Transfusion
Summary
Further Reading
Websites
CHAPTER 12: Waste Products, Electrolytes, and Renal Disease
12.1 Renal Anatomy and Physiology
12.2 Homeostasis
12.3 Excretion
12.4 Renal Endocrinology
12.5 Renal Disease
12.6 Case Studies
Summary
Further Reading
Websites
CHAPTER 13: Hydrogen Ions, pH, and Acid–Base Disorders
13.1 Ions and Molecules
13.2 Blood Gases
13.3 Acidosis (pH < 7.3)
13.4 Alkalosis (pH>7.5)
13.5 Mixed Acid–Base Conditions
13.6 Clinical Interpretation
13.7 Genetics of Acid/Alkali Homeostasis
13.8 Case Studies
Summary
Further Reading
Website
CHAPTER 14: Glucose, Lipids, and Atherosclerosis
14.1 Glucose
14.2 Dyslipidaemia
14.3 Atherosclerosis
14.4 Case Studies
Summary
Further Reading
Websites
CHAPTER 15: Calcium, Phosphate, Magnesium, and Bone Disease
15.1 Calcium
15.2 Phosphates
15.3 Magnesium
15.4 The Laboratory
15.5 Disorders of Calcium Homeostasis
15.6 Disorders of Phosphate Homeostasis
15.7 Disorders of Magnesium Homeostasis
15.8 Bone Physiology
15.9 Bone Disease
15.10 Case Studies
Summary
Further Reading
Websites
CHAPTER 16: Nutrients and Gastrointestinal Disorders
16.1 Nutrients
16.2 Intestinal Tract Physiology
16.3 Intestinal Tract Pathology
16.4 Case Studies
Summary
Further Reading
CHAPTER 17: Liver Function Tests and Plasma Proteins
17.1 Anatomy and Physiology of the Liver
17.2 Liver Function Tests
17.3 Diseases of the Liver
17.4 LFTs in Liver Disease
17.5 Plasma Proteins
17.6 Molecular Genetics in Liver Disease
17.7 Case Studies
Summary
Further Reading
Websites
CHAPTER 18: Endocrinology
18.1 Endocrine Physiology
18.2 The Pathology of the Endocrine System
18.3 Case Studies
Summary
Further Reading
Websites
CHAPTER 19: Cancer and Tumour Markers
19.1 General Concepts in Cancer Biology
19.2 Blood Science and Cancer
19.3 Molecular Genetics
19.4 Case Studies
Summary
Further Reading
Websites
CHAPTER 20: Inherited Metabolic Disorders
20.1 The Genetics of Inheritance
20.2 Molecular Inherited Metabolic Disorders
20.3 Organelle‐Inherited Metabolic Disorders
20.4 Ante‐natal Diagnosis and Neonatal Screening
20.5 Case Studies
Summary
Further Reading
CHAPTER 21: Drugs and Poisons
21.1 Toxicology
21.2 Toxicology of Specific Compounds
21.3 Therapeutic Drug Monitoring
21.4 Case Studies
Summary
Further Reading
CHAPTER 22: Case Reports in Blood Science
Abbreviations
Case Report 1
Additional Analyses
Case Report 2
Case Report 3
Case Report 4
Case Report 5
Case Report 6
Case Report 7
Case Report 8
Case Report 9
Case Report 10
Case Report 11
Case Report 12
Case Report 13
Case Report 14
Case Report 15
Acknowledgements
Further Reading
Answers to Case studies
Appendix: Reference Ranges
Index
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