دانلود کتاب Cancer Neuroscience

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Preface
Contents
Introduction
Part I: Cancer and the Central Nervous System
Chapter 1: Neuronal Activity in Brain Tumor Pathogenesis: Adding to the Complexities of Central Nervous System Neoplasia
Cellular Origins of Glioma
Effect of Neuronal Activity on NSC Dynamics
Effect of Neuronal Activity on OPC Dynamics
Neuron-OPC Synapses
Activity-Dependent Pathogenesis of Gliomas
Activity-Dependent Mitogens for Glioma
Activity-Dependent Glioma Initiation in Cancer Predisposition Syndromes
Neuron-Glioma Synapses
Effect of Synaptogenic Factors on Neuron-Glioma Synapses
Gap Junctions in Brain Tumors
Extracellular Vesicles as Potential Activity-Dependent Factors in Brain Tumor Pathogenesis
Targeting Neuron-Tumor Interactions in the CNS
Conclusion
References
Chapter 2: Neuron-Cancer Synaptic and Other Electrical Signaling
References
Chapter 3: Mechanisms of Cancer-Induced Remodeling of the Central Nervous System
Neuronal Regulation of Glioma
Neuronal Activity-Dependent Regulation of Glioma Growth and Progression
Molecular Mechanisms of Neuronal Regulation of Glioma Growth
Activity-Regulated Secretion of Paracrine Factors
Neurotrophins
Neurotransmitters
Neuronal Activity-Evoked Direct Electrochemical Signaling
Neuronal Activity-Dependent Regulation of Glioma Initiation
Neuronal Activity-Dependent Regulation of Glioma Invasion
Neuronally Driven Glioma-Glioma Connections
Glioma Regulation of Neuronal Excitability
Glioma-Induced Neuron-Neuron Connections and Network Remodeling
Therapeutic Implications and Future Work
References
Part II: Cancer and the Peripheral Nervous System
Chapter 4: Neural Influence on Cancer Invasion and Metastasis
Introduction
Nerve Structure
Influence of Cells Within Nerves on Tumor Invasion and Metastasis
Neuronal Cells
Direct Effect on Tumor Cells
Effects on the Tumor Microenvironment
Schwann Cells
Direct Effects on Tumor Cells
Effects on Tumor Microenvironment
Endoneurial Macrophages
Summary
References
Chapter 5: Cancer Induced Remodeling of the Peripheral Nervous System
Tumor Profiling Promotes Differences in Innervation and Peripheral Nerve Remodeling
Cancer-Mediated Remodeling Mechanisms
Remodeling by Cancer-Secreted Proteins and Cytokines
Remodeling by Transfer of Genetic Material
Remodeling by Cellular Stress and Dysfunction
Recent Advancements and Future Directions
References
Chapter 6: Neuroimmune Interactions and Their Role in Carcinogenesis
Introduction
Neuronal-Dependent Immune Regulation
Sensory Nerve-Mediated Immune Reactions
Substance P
Adrenergic Signaling-Mediated Immune Signaling
Cholinergic Signaling-Mediated Immune Signaling
The Nonneuronal Release of Neurotransmitters
Checkpoint-Mediated Neuronal Immune Regulation
Glial Cells in Cancer
Emerging Therapeutics Targeting the Neuroimmune Network
Conclusion
References
Chapter 7: Neuroimmunoregulation of Cancer: The Case for Multiple Myeloma
Introduction
A Role for Stress in the Progression of Multiple Myeloma
Multiple Myeloma and Bone Marrow Immune Microenvironment
Neural Regulation of the Immune Microenvironment in Multiple Myeloma
Systemic Factors Influencing the Immune Microenvironment
Therapeutic Alteration of the Immune Microenvironment: Role of Beta-Blockers
Conclusions
References
Chapter 8: Nervous System Interactions with Nonimmune Elements in Cancer Microenvironment: A Missing Piece?
Introduction
Neuron-Fibroblast Interactions in Cancer
Neuron- Endothelium Interactions in Cancer
Schwann Cell-Stroma Interactions
Conclusion
References
Chapter 9: Reprogrammed Schwann Cells in Cancer
Introduction
Clinical Significance of the Presence of SCs in Cancer
Reprogrammed SCs
Reprogrammed SCs in Nerve Repair and in Mycobacterium leprae Infection
Reprogrammed SCs in Cancer
Mechanism of SC Reprogramming
Function of Reprogrammed SCs in Cancer Proliferation, Migration, and Invasion
SC Secretory Factors and Cancer Progression
SC Ability to Alter the Matrix
SC Physical and Mechanical Properties: Formation of TASTs
Conclusion
References
Part III: Perspectives of the Field
Chapter 10: Systemic Interactions Between Cancer and the Nervous System
Introduction
How Does the Nervous System Control Cancer Development?
Direct Pathways
Cellular Connections
Paracrine Signaling Pathways
Indirect Pathways
How Does Cancer Influence Nervous System Function?
Behavioral Consequences of Cancer-Nerve Cross Talk
Neural Regulation in Cancer Therapy Resistance
Conclusion and Future Directions
References
Chapter 11: Tools and Model Systems to Study Nerve-Cancer Interactions
Introduction
Visualizing Tissue and Cellular Architecture
Modifying and Measuring Nerve Signaling
Multimodal Genomic Analysis
Modulating Gene Expression
Future Prospects
Concluding Remarks
References
Chapter 12: Future Direction of Cancer Neuroscience
Why Do Nerves Make Tumors Feel Welcome?
Anatomical Considerations
Intercellular Interactions
Immunosuppression
Exploration of the “Safe Harbor Hypothesis”: Future Directions
How Nervy Are Tumors?
Dissecting Neuronal Contribution to the TME
Concluding Remarks: Confirmation Bias
References
Index