دانلود کتاب Cell Migration: Signalling and Mechanisms (Translational Research in Biomedicine, Vol. 2)

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Contents......Page 6
Foreword......Page 7
Preface......Page 9
Abstract......Page 10
References......Page 14
Abstract......Page 16
HSC/HSPC Mobilization......Page 19
HSC/HSPC Homing......Page 21
The SDF-1α/CXCR4 Axis......Page 23
Modulation of the SDF-1α-Induced Migration of HSPCs......Page 26
Cancer Stem Cell Migration......Page 27
Conclusion......Page 30
References......Page 31
Basic Steps of Cell Movement......Page 37
Cell Signaling during Neutrophil-Directed Migration......Page 38
Neutrophil Motility in Disease......Page 43
Neutrophil Motility in Chronic Inflammatory Disease......Page 44
Conclusion......Page 45
References......Page 46
Leukocyte Polarization......Page 49
Sensing Chemotactic Gradients......Page 52
Establishment of Two Poles: Front-Back Coordination......Page 54
Microtubule Connection: The Lost Link?......Page 56
Segregated Signalling Domains in Polarized Lymphocytes......Page 58
References......Page 60
Abstract......Page 63
Class 1 PI3Ks: An Overview......Page 64
A Role for PI3K in Cell Migration: The Story So Far......Page 65
Evidence for PI3K-Dependent and -Independent T-Lymphocyte Directional Migration......Page 66
Role of PI3K in T-Lymphocyte Homing and Migration in vivo: Lessons from Gene-Targeted from Mice......Page 67
Antigen Recognition by the TCR and Costimulatory Receptors Influence T-Cell Trafficking......Page 68
Conclusions......Page 70
References......Page 72
Abstract......Page 76
Migration and Trafficking Receptors of T Cells......Page 77
Generation of the Functionally Specialized T-Helper Cell Subsets......Page 78
Migration and Function of TFH Cells......Page 79
Migration and Function of Th17 Cells......Page 82
Migration and Function of FoxP3+ Cells......Page 84
Concluding Remarks......Page 85
References......Page 86
Abstract......Page 92
Leukocyte Trafficking......Page 93
ADAMs and Ectodomain Shedding of Leukocyte Receptors......Page 95
ADAMs and Ectodomain Shedding of Endothelial Receptors......Page 100
Crossing the Basement Membrane and Interstitial Migration......Page 101
How, Where and When Are ADAMs Activated......Page 102
Regulation of ADAM10 and 17 Proteolytic Activity......Page 103
Regulation of ADAM15 Function by Interacting Kinases......Page 104
Conclusions and Future Prospects......Page 105
References......Page 106
Abstract......Page 111
Induction of Migratory Activity by Extracellular Signal Substances......Page 112
Pathways Leading to Cell Migration (Cytokines and Neurotransmitters)......Page 118
References......Page 123
Abstract......Page 129
E-Cadherin-Mediated Adherens Junctions......Page 130
Regulation of E-Cadherin Gene Expression......Page 131
Regulation of the E-Cadherin Adhesion Complex by β-Catenin......Page 134
Regulation of Cell-Cell Adhesion by the Cellular Microenvironment......Page 136
Regulation of Cell-Cell Adhesion by p120ctn and GTPases......Page 138
References......Page 140
The Cell Adhesion Complex: A Simplistic View......Page 145
Proteins: Biochemical Characteristics and Molecular Architecture......Page 147
Cell Adhesion Complex: Protein Properties in the Cellular Context......Page 150
Cell Migration: Regulation of Adaptor Proteins during Contact Turnover......Page 156
Organism: Specific Tasks in Tissues and Organs......Page 164
Concluding Remarks......Page 165
References......Page 166
The Myosin Superfamily......Page 172
Myosin II......Page 175
Myosin V......Page 176
Myosin X......Page 178
References......Page 179
Author Index......Page 182
Subject Index......Page 183