دانلود کتاب Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity

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Front Matter....Pages I-XXIV
Front Matter....Pages 1-1
The Uridine Diphosphate Glucuronosyltransferase Multigene Family: Function and Regulation....Pages 3-43
Sulfotransferase Enzymes....Pages 45-78
Regulation of Expression of Rat Liver Glutathione S-Transferases: Xenobiotic and Antioxidant Induction of the Ya Subunit Gene....Pages 79-107
Human N -Acetyltransferases....Pages 109-130
Genetic Regulation of the Subcellular Localization and Expression of Glucuronidase....Pages 131-160
Microsomal Amidases and Carboxylesterases....Pages 161-187
O -, N - and S -Methyltransferases....Pages 189-216
Front Matter....Pages 217-217
Cofactor Supply as a Rate-Limiting Determinant of Hepatic Conjugation Reactions....Pages 219-244
Regulation of Drug Conjugate Production by Futile Cycling in Intact Cells....Pages 245-255
Pharmacokinetic Modeling of Drug Conjugates....Pages 257-309
Regulation of Drug Conjugate Processing by Hepatocellular Transport Systems....Pages 311-338
Front Matter....Pages 339-339
Biologically Active Conjugates of Drugs and Toxic Chemicals....Pages 341-366
Acyl Glucuronides as Chemically Reactive Intermediates....Pages 367-389
Roles of Uridine Diphosphate Glucuronosyltransferases in Chemical Carcinogenesis....Pages 391-428
Sulfonation in Chemical Carcinogenesis....Pages 429-457
Glutathione Conjugate-Mediated Toxicities....Pages 459-509
Challenges and Directions for Future Research....Pages 511-524
Back Matter....Pages 525-530