دانلود کتاب Contemporary Management of Metastatic Colorectal Cancer: A Precision Medicine Approach

فهرست مطالب :

Front Matter
Front Matter
Copyright
Dedication
References
Chapter 1 Epidemiology and risk factors for metastatic colorectal disease
Colorectal cancer incidence and survival
Risk factors for colorectal cancer
Screening guidelines
Summary
References
Chapter 2 The tumor microenvironment of colorectal cancer liver metastases: Molecular mediators and future therapeutic targets
Introduction
The unique immune microenvironment of the liver
Role of liver sinusoidal endothelial cells
The natural killer cells of the liver
Liver dendritic cell functions
Neutrophils opposing roles in liver metastasis progression
Myeloid-derived suppressor cells \\(MDSCs\\) promote liver metasasis by diverse mechanisms
Role of hepatic stellate cells
Multiple factors combine to inhibit a cytolytic T cell response to metastatic cancer cells
The extracellular matrix regulates cancer cell survival and growth in the liver
The unique extracellular matric \\(ECM\\) of the liver and liver metastases
The ECM and cell adhesion molecules
The effect of ECM stiffness
Potential strategies for targeting the microenvironment of CRLM and increasing immunotherapy efficacy in patients
Conclusion
Acknowledgements
References
Chapter 3 Pre-operative imaging, response evaluation, and surgical planning ^^e2^^80^^93 CT, PET, radiomics, and FLR measurement
Introduction
Role of imaging in CRLM
Pre-operative imaging of CRLMs
Initial staging
Ultrasonography \\(US\\)
Computed tomagraphy \\(CT\\)
Magnetic resonance imaging \\(MRI\\)
Fluorodeoxyglucose-positron emission tomography \\(FDG-PET\\)
Assessment of prognosis and surgical candidacy
Use of imaging for surgical planning
Pre-operative treatment and response evaluation of CRLM
Downsizing of initially unresectable lesions
Increasing future remnant liver volume and volumetric assessment
Volumetric assessment
Increasing future remnant liver volume
Alternative therapies for CRLM
Ablation
Hepatic artery infusion \\(HAI\\) and selective internal radiation therapy \\(SIRT\\)
Conclusion
Bibliography
Chapter 4 Use of molecular markers and other personalized factors in treatment decisions for metastatic colorectal cancer
Introduction
Prognostic versus predictive
Disease characteristics
Histology
Pharmacogenetics for conventional cytotoxic chemotherapy
KRAS
BRAF
HER2
DNA microsatellite instability and immunotherapy
Tumor sidedness
Circulating tumor cells and cell free DNA
Gut microbiome
Conclusions
References
Chapter 5 Role of Neoadjuvant therapy in the treatment of patients with colorectal liver metastases
Introduction
Rationale for perioperative chemotherapy for colorectal liver metastases
Preoperative chemotherapy for patients with unresectable liver metastases
Neoadjuvant chemotherapy for resectable liver metastases
Safety of neoadjuvant chemotherapy for colorectal liver metastases
Conclusions
References
Chapter 6 Management of the disappeared colorectal liver metastasis
Introduction
Defining disappearing colorectal liver metastasis \\(DLM\\)
Predictors of DLM pathologic response
Intra-Operative evaluation of DLM
Surgical resection versus surveillance of DLM
Summary
References
Chapter 7 Approach to small liver remnant ^^e2^^80^^93 strategies to increase resectability
Introduction
Future liver remnant \\(FLR\\)
Calculating FLR
Optimal future liver volume
Portal vein embolization \\(PVE\\)
Indications and contraindications for PVE
Portal vein ligation, a historical perspective
Technical aspects of PVE
Post-PVE hypertrophy/kinetic growth rate
Combined portal vein & hepatic vein embolization
Associating liver partition and portal vein ligation
Conclusion
References
Chapter 8 Two-stage versus ALPPS for large intrahepatic burden of colorectal liver metastasis
FLR hypertrophy and feasibility to complete both stages
Morbidity and Mortality
Oncological results
Conclusion
References
Chapter 9 Synchronous colorectal liver metastasis ^^e2^^80^^93 simultaneous vs. staged approach
Introduction
Sequencing of care for sCRLM
Perioperative chemotherapy
Simultaneous approach
Staged approaches: primary-first
Staged approaches: liver-first
Surgical approach summary
MSK approach
Case-based learning
References
Chapter 10 Minimally invasive approaches to colorectal liver metastases
Introduction
Laparoscopic liver resection
Background
Outcomes
Robotic liver resection
Background
Outcomes
Laparoscopic radiofrequency ablation
Background
Outcomes
Laparoscopic microwave coagulation
Background
Outcomes
Conclusion
References
Chapter 11 Hepatic resection of colorectal liver metastasis in the presence of extrahepatic disease
Incidence of extrahepatic disease
Diagnosis of extrahepatic disease
Role of surgery in patients with extrahepatic disease
Recurrence
Lung metastases
Lymph node metastases
Peritoneal metastases
Conclusions
References
Chapter 12 Locoregional approaches to colorectal liver metastasis ^^e2^^80^^93 ablation
Introduction
Indications and contraindications
Radiofrequency vs microwave ablations
Ablation approaches
Post-ablation complications
Surveillance
Local recurrence rates
Long-term outcomes
Long-term outcomes of the multi-modality treatments
Summary points
Disclosure statement
References
Chapter 13 Locoregional approaches to colorectal liver metastasis ^^e2^^80^^93 intra-arterial
Introduction
Embolic therapies
Indications and outcomes
Summary of embolic therapies
Transarterial radioembolization \\(TARE\\)
Hepatic artery infusion chemotherapy \\(HAIC\\)
HAIP: function and insertion
Indications, contraindications, and other complications
Summary of hepatic arterial infusion chemotherapy
HAIC outcomes relative to other intra-arterial therapies
Conclusions
Case stem
References
Chapter 14 Locoregional Approaches to Colorectal Liver Metastasis ^^e2^^80^^93 Radiation Options
Introduction: external beam radiation therapy \\(EBRT\\) for colorectal liver metastases
External beam radiation: rationale for ablative dosing
External beam radiation: patient selection
External beam radiation: treatment planning considerations
External beam radiation: target volume design and treatment objectives
External beam radiation: outcomes and surveillance considerations
Future directions
References
Chapter 15 Immunotherapy and targeted therapies for colorectal liver metastasis
Targeted therapy in CRC with CLM
Resectable CLM at diagnosis with no extra-hepatic metastatic disease
Unresectable CLM at diagnosis with a potential for resection with no extra-hepatic metastatic disease
CLM with no potential for resection and/or unresectable extra-hepatic disease
First-line therapy- in combination with chemotherapy
Subsequent lines of therapy
Immunotherapy
References
Chapter 16 Adjuvant therapy following resection of colorectal liver metastases
Introduction
Timing of systemic treatment
Role of adjuvant treatment
Adjuvant intra-arterial chemotherapy following resection of colorectal liver metastases
Conclusion
Clinical case
References
Chapter 17 Long-term prognosis and surveillance of patients with resected colorectal liver metastasis
Introduction
Clinical risk scores
Other prognostic tools
Inflammatory and immune predictors of survival
Predicting recurrence
Surveillance and recurrence
Conclusion
References
Chapter 18 Management of secondary recurrence of intra-hepatic colorectal liver metastasis following initial hepatic resection
Introduction
Surveillance following initial hepatectomy
Frequency of testing
Length of surveillance
Testing parameters
Repeat liver resection
Technical considerations
Published experience with repeat hepatectomy
Early recurrence
Other treatment modalities
Systemic therapy
Ablation therapy
Ablative radiation
Transarterial chemoembolization \\(TACE\\)
Transarterial radioembolization \\(TARE\\)
Hepatic artery infusion chemotherapy \\(HAIC\\)
Transplant
References
Chapter 19 Colorectal liver metastasis: survivorship
Introduction
What is a cancer survivor?
Colorectal cancer survivors with liver metastases
Surveillance for recurrence and screening for second primary cancers
Prognosis
Disparities in metastatic colorectal cancer survival
Surveillance and screening
Assessment and management of physical and psychosocial effects of colorectal cancer and treatment
Methods of assessment
Post-Diagnosis pain
Fatigue and physical activity
Mood/Mental health/depression/fear
Bowel function
Ostomy-Specific concerns
Sexual wellness
Financial burden
Specific HRQoL outcomes in patients with colorectal cancer liver metastases
Routine health promotion needs
Coordination of care among specialists and primary care clinicians
Experience with healthcare providers
Progressive disease
Palliative care involvement
Limitations and future directions
Surveillance for recurrence and screening for second primary cancers
Assessment and management of physical and psychosocial effects of colorectal cancer and treatment
Coordination of care among specialists and primary care clinicians
Summary
References
Contents
Contributors
Index