دانلود کتاب Developments in Statistical Evaluation of Clinical Trials

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Front Matter....Pages i-xi
Statistical Models and Methods for Incomplete Data in Randomized Clinical Trials....Pages 1-27
Bayesian Decision Theory and the Design and Analysis of Randomized Clinical Trials....Pages 29-50
Designing Multi-arm Multi-stage Clinical Studies....Pages 51-69
Statistical Approaches to Improving Trial Efficiency and Conduct....Pages 71-84
Competing Risks and Survival Analysis....Pages 85-96
Recent Developments in Group-Sequential Designs....Pages 97-118
Statistical Inference for Non-inferiority of a Diagnostic Procedure Compared to an Alternative Procedure, Based on the Difference in Correlated Proportions from Multiple Raters....Pages 119-137
Design and Analysis of Clinical Trial Simulations....Pages 139-151
Causal Effect Estimation and Dose Adjustment in Exposure-Response Relationship Analysis....Pages 153-175
Different Methods to Analyse the Results of a Randomized Controlled Trial with More Than One Follow-Up Measurement....Pages 177-193
Statistical Methods for the Assessment of Clinical Relevance....Pages 195-207
Statistical Considerations in the Use of Composite Endpoints in Time to Event Analyses....Pages 209-226
Statistical Validation of Surrogate Markers in Clinical Trials....Pages 227-246
Biomarker-Based Designs of Phase III Clinical Trials for Personalized Medicine....Pages 247-263
Dose-Finding Methods for Two-Agent Combination Phase I Trials....Pages 265-282
Multi-state Models Used in Oncology Trials....Pages 283-304
Review of Designs for Accommodating Patients’ or Physicians’ Preferences in Randomized Controlled Trials....Pages 305-333
Dose Finding Methods in Oncology: From the Maximum Tolerated Dose to the Recommended Phase II Dose....Pages 335-361