دانلود کتاب Drug Delivery Systems for Musculoskeletal Tissues

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Preface
Contents
Chapter 1: Introduction to Musculoskeletal Tissues and Drug Delivery Systems
1 Musculoskeletal Tissues
1.1 Types of Musculoskeletal Tissues
1.1.1 Bone
1.1.2 Cartilage
1.1.3 Muscle
1.1.4 Intervertebral Disc
1.1.5 Ligaments and Tendons
1.2 Understanding Pathologies of Musculoskeletal Tissues
2 Drugs for Musculoskeletal Pathologies
2.1 Low-Molecular-Weight Drugs
2.2 Therapeutic Nucleic Acids
2.3 Peptide Drugs
2.4 Stem Cell Therapy
3 Prerequisites for Musculoskeletal Drug Delivery Systems
3.1 Microenvironment-Based Requirements
3.2 Mechanical Requirements
4 Drug Delivery Systems
4.1 Hydrogels
4.2 Nanotechnology-Based Drug Delivery Systems
4.3 Implant Coatings
4.4 3D Scaffolds
5 Outlook
References
Chapter 2: Drug Delivery Systems for Bone
1 Bone Defects and Existing Surgical Treatment Strategies
1.1 General Pathophysiology for Bone Defect Repair
1.2 Existing Strategies for Critically Sized Bone Defect Repair
2 Bioactive Factors for Healing of Bone Defects
2.1 Drug Delivery for Improved Osteogenesis
2.2 Drug Delivery for Managing the Inflammatory Response
2.3 Drug Delivery for Improving Neovascularization During Repair
3 Biomaterials-Based Drug Delivery Platforms for Bone Defect Repair
3.1 Scaffold-Based Release Systems
3.2 Synthetic Micro- and Nano-particle Carrier Systems
3.3 Multiphasic Drug Release
3.4 Triggering Controlled Release Systems (Smart Release)
3.5 Potential Future for Drug Delivery in Bone: Natural and Nonimmunogenic Carriers
References
Chapter 3: Drug Delivery Systems for Cartilage
1 Introduction
2 Cartilage-Related Diseases
2.1 Cartilage Development Disorders
2.1.1 Osteochondritis Dissecans (OD)
2.1.2 Relapsing Polychondritis
2.1.3 Chondrocalcinosis
2.1.4 Cartilaginous Tumors
2.1.5 Inflammatory Arthropathies
2.2 Cartilage Injuries
2.2.1 Osteoarthritis
2.2.2 Costochondritis
2.2.3 Herniation
2.2.4 Achondroplasia (ACH)
3 Current Treatment Strategies
3.1 Surgical Approaches
3.1.1 Subchondral Drilling
3.1.2 Microfracture
3.1.3 Bone Marrow Aspirate Concentrate
3.1.4 Osteochondral Autograft Transplantation
3.1.5 Osteochondral Allograft Transplantation (OCA)
3.1.6 Particulate Juvenile Allograft Cartilage
3.1.7 Cryopreserved Viable Osteochondral Allograft
3.1.8 Autologous Chondrocyte Implantation and Matrix-Induced Autologous Chondrocyte Implantation
3.1.9 Particulate Autologous Cartilage Implantation
3.1.10 Autologous Matrix-Induced Chondrogenesis
3.2 Tissue Engineering
3.3 Cell-Based Therapy
3.3.1 Mesenchymal Stromal Cells
3.3.2 Peripheral Blood Stem Cells (PBSCs)
3.3.3 Bone Marrow Stem Cells
3.3.4 Umbilical Cord-Derived Mesenchymal Stem Cells
3.3.5 Adipose Tissue-Derived Mesenchymal Stem Cells
3.3.6 Platelet-Rich Plasma
4 Drug Delivery Systems Used in Cartilage Repair and Regeneration
4.1 Nanoparticle-Based DDS
4.1.1 Inorganic Nanoparticles
4.1.2 Liposome-Based Drug Delivery Systems
4.1.3 Dendrimer-Based Drug Delivery Systems
4.1.4 Micelle-Based Drug Delivery System
4.1.5 Nanoemulsion-Based Drug Delivery System
4.1.6 Nanogel-Based Drug Delivery System
4.2 Microparticle-Based Drug Delivery Systems
4.3 Hydrogel-Based Drug Delivery Systems
4.4 Transdermal Drug Delivery Systems
4.5 Delivery Molecules in Cartilage Repair and Regeneration
4.5.1 Growth Factors and Peptides
5 Challenges for Drug Delivery System
6 Conclusion
References
Chapter 4: Drug Delivery Systems for Intervertebral Disc
1 Introduction
2 Anatomy of Intervertebral Disc
2.1 Annulus Fibrosus
2.2 Nucleus Pulposus
2.3 Cartilaginous Endplate
2.4 Extracellular Matrix
3 Intervertebral Disc Degeneration
4 Current Clinical Treatments
4.1 Pharmacological Therapy
4.2 Non-Pharmacological Therapy
4.3 Surgical Treatments
4.4 Small Molecules
4.5 Proteins and Peptides
4.6 Antibodies and Cytokine Inhibitors
4.7 Enzymes Inhibitors
4.8 Nucleic Acids
4.9 Cell Therapies
5 Drug Delivery Nanosystems
5.1 Nanoparticles
5.2 Nanofibres
5.3 Liposomes
5.4 Dendrimers
5.5 Micelles
6 Drug Delivery Microsystems
6.1 Microspheres
6.2 Microparticles
7 Drug Delivery Macrosystems
7.1 Polymeric Hydrogels
7.2 Injectable Devices
7.3 Controlled-Release Implants
8 Conclusion and Future Perspective
References
Chapter 5: Drug Delivery Systems for Tendon and Ligament
1 Introduction
1.1 Tendon and Ligament Injuries and the Need for New Drug Delivery Systems
1.2 Tendon Structure-Informed Drug Delivery Systems
1.3 Tendon Healing-Informed Drug Delivery Systems
2 Drug Delivery Systems and Treatments for Tendon and Ligament Injuries and Disorders
2.1 Surgery
2.2 Physical Therapy
2.3 Small-Molecule Drug Delivery
2.4 Growth Factor Protein Delivery
2.5 Gene Delivery
2.6 Platelet-Rich Plasma (PRP) Delivery
2.7 Cellular Drug Delivery Systems
2.8 Biomaterial-Based Drug Delivery Systems
2.8.1 Tissue Grafts and Decellularized Matrices
2.8.2 Natural Biomaterial Drug Delivery Systems
2.8.3 Synthetic Biomaterial Drug Delivery Systems
2.9 Other Drug Delivery Formats
3 Integrated Drug Delivery Systems
4 Conclusion and Future Outlook
References
Chapter 6: Drug Delivery Systems for Muscles
1 Structural and Molecular Basis of Muscles in the Musculoskeletal System
1.1 Anatomy and Histology of Muscles of the Musculoskeletal System
1.2 Molecular Biology of Muscles of the Musculoskeletal System
1.3 Muscle-Related Diseases
1.4 Current Treatment Strategies
2 Muscle-Targeted Drugs
2.1 Low-Molecule and Peptide-Based Drugs
2.2 Gene Therapy
2.3 Cell Therapy
3 Drug Delivery Strategies for Muscle
3.1 Targeting Ligands
3.2 Nanoparticle-Based Delivery
3.3 Utilization of External Stimuli
4 Perspectives
References
Chapter 7: Challenges in Clinical Translation of Musculoskeletal Drug Delivery Systems
1 Introduction
2 Regulatory Challenges
3 Challenges in the Scale-Up Process
4 Biological Challenges
5 Material-Based Challenges
6 Conclusion
References
Index