دانلود کتاب Electrospray and MALDI mass spectrometry: fundamentals, instrumentation, practicalities, and biological applications

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Electrospray and MALDI Mass Spectrometry......Page 3
Contents......Page 7
Foreword: Desorption Ionization and Spray Ionization: Connections and Progress......Page 9
Foreword to the First Edition......Page 23
Preface......Page 29
Contributors......Page 31
Part I Fundamentals of ES......Page 33
1. On the Mechanism of Electrospray Ionization Mass Spectrometry (ESIMS)......Page 35
2. Selectivity in Electrospray Ionization Mass Spectrometry......Page 81
3. Electrochemistry of the Electrospray Ion Source......Page 107
4. ESI Source Design......Page 155
Part II Fundamentals of MALDI......Page 179
5. MALDI Ionization Mechanisms: an Overview......Page 181
6. The Development of Matrix-Assisted Laser Desorption/Ionization Sources......Page 217
7. A Comparison of MALDI Matrices......Page 247
8. MALDI Imaging Mass Spectrometry......Page 277
Part III ES and MALDI Coupling to Mass Spectrometry Instrumentation......Page 295
9. Coupling ESI and MALDI Sources to the Quadrupole Mass Filter, Quadrupole Ion Trap, Linear Quadrupole Ion Trap, and Orbitrap Mass Analyzers......Page 297
10. Time-of-Flight Mass Spectrometry......Page 377
11. Fourier Transform Ion Cyclotron Resonance and Magnetic Sector Analyzers for ESI and MALDI......Page 397
12. Ion Mobility–Mass Spectrometry......Page 443
Part IV Practical Aspects of ES and MALDI......Page 473
13. ESI, APCI, and MALDI A Comparison of the Central Analytical Figures of Merit: Sensitivity, Reproducibility, and Speed......Page 475
14. Charge State Distributions in Electrospray and MALDI......Page 523
15. Probing Noncovalent Interactions by Electrospray Ionization and Matrix-Assisted Laser Desorption/Ionization......Page 567
16. Ion Activation Methods for Tandem Mass Spectrometry......Page 603
17. Dissociation of Even-Electron Ions......Page 663
Part V Biological Applications of ES and MALDI......Page 715
18. The Role of Mass Spectrometry for Peptide, Protein, and Proteome Characterization......Page 717
19. Carbohydrate Analysis by ESI and MALDI......Page 755
20. Applications of ESI and MALDI to Lipid Analysis......Page 803
21. In Vitro ADME Profiling and Pharmacokinetic Screening in Drug Discovery......Page 831
Index......Page 857