دانلود کتاب Epigenetic targets in drug discovery

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Content:
Chapter 1 New Frontiers in Epigenetic Modifications (pages 1–22): Adam L. Garske and John M. Denu
Chapter 2 Structural Biology of Epigenetic Targets (pages 23–56): Christophe Romier, Jean?Marie Wurtz, Jean?Paul Renaud and Jean Cavarelli
Chapter 3 Computer? and Structure?Based Lead Identification for Epigenetic Targets (pages 57–85): Ralf Heinke, Urszula Uciechowska and Prof., Dr. Wolfgang Sippl
Chapter 4 Histone Modification Analysis Using Mass Spectrometry (pages 87–97): Ana Villar?Garea and Axel Imhof
Chapter 5 In Vitro Assays for Histone?Modifying Enzymes (pages 99–118): Alexander?Thomas Hauser and Prof., Dr. Manfred Jung
Chapter 6 Epigenetic Targets in Drug Discovery: Cell?Based Assays for HDAC Inhibitor Hit Validation (pages 119–137): Mira Jung, Kwon?Jeong Yong, Alfredo Velena and Sung Lee
Chapter 7 Chromatin Immunoprecipitation ChIP: Wet Lab Meets In Silico (pages 139–159): Martin Seifert and Robert Schneider
Chapter 8 DNA Methyltransferase Inhibitors (pages 161–183): Prof., Dr. Wolfgang Sippl and Prof., Dr. Manfred Jung
Chapter 9 Histone Deacetylase Inhibitors (pages 185–223): Philip Jones
Chapter 10 NAD?Dependent Deacetylases as Therapeutic Targets (pages 225–242): Hongzhe Li, Julian Simon and Antonio Bedalov
Chapter 11 Inhibitors of Histone Acetyltransferases: Discovery and Biomedical Perspectives (pages 243–250): Margarete von Wantoch Rekowski and Athanassios Giannis
Chapter 12 Histone Methyltransferases as Novel Drug Targets (pages 251–268): Prof., Dr. Manfred Jung
Chapter 13 Histone Demethylases (pages 269–290): Rasmus P. Clausen, Marianne T. Pedersen and Kristian Helin