دانلود کتاب Exercise and stress response: the role of stress proteins

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Exercise and Stress Response: The Role of Stress Proteins......Page 3
About the Editors......Page 5
Contributors......Page 6
Contents......Page 8
I. Introduction......Page 9
III. Hans Selye and the stress response......Page 10
IV. History of the cellular stress response......Page 11
V. Stress protein inducers......Page 13
VII. Constitutive expression of stress proteins......Page 14
VIII. Stress protein function......Page 16
IX. Conclusions......Page 17
References......Page 18
I. Introduction......Page 21
II. Heat shock transcription factors......Page 23
III. Functional organization of HSF1......Page 25
IV. Regulation of HSF1 activity......Page 26
A. Cellular localization of HSF1......Page 27
B. Trimerization and DNA binding......Page 28
1. HSF1 repression domains......Page 31
2. Regulation by phosphorylation......Page 32
V. Transcriptional activation of the heat shock genes by HSF1......Page 34
VI. Attenuation of the heat shock response......Page 35
VII. Sensing and transduction of the stress signal......Page 36
VIII. Summary and perspectives......Page 38
References......Page 40
Addendum (November 7, 2001)......Page 49
I. Introduction......Page 50
A. Ubiquitin......Page 51
B. Small HSPs......Page 52
D. HSP47......Page 54
E. HSP70 family......Page 55
F. HSP90 family......Page 57
III. Heat shock protein induction with exercise......Page 58
A. Acute exercise......Page 59
B. Exercise training......Page 61
C. Fiber-specific expression......Page 63
IV. Functional consequences of exercise-induced HSP expression......Page 65
V. Summary and future directions......Page 67
References......Page 68
I. Introduction......Page 86
1. Binding to denatured protein......Page 87
B. HSP70, exercise, and protein synthesis......Page 90
1. Binding to denatured protein and cellular dynamics......Page 92
2. Phosphorylation of HSP25......Page 93
B. HSP25, exercise, and protein synthesis......Page 94
IV. Conclusion......Page 96
References......Page 97
I. Introduction......Page 104
II. Types of reperfusion injury......Page 105
III. Experimental models......Page 106
IV. Heat shock and cardioprotection......Page 107
A. HSP70......Page 108
B. Catalase and superoxide dismutase......Page 111
A. Chronic exercise studies......Page 113
B. Acute exercise studies......Page 118
VI. Coronary vasculature dysfunction......Page 121
VII. Summary......Page 123
References......Page 124
chapter six: Heat shock proteins and reactive oxygen species......Page 1
I. Introduction......Page 129
II. Reactive oxygen species and oxidative stress: an overview......Page 130
1. Lipid peroxidation and protein oxidation......Page 131
III. Antioxidant defense mechanisms......Page 132
B. Antioxidants and activation of HSP genes......Page 133
Acknowledgments......Page 136
References......Page 137
I. Introduction......Page 142
II. Location and function of HSPs in resting skeletal muscle......Page 143
A. Production of HSPs in skeletal muscle following an acute period of exercise......Page 144
C. Production of HSPs in the skeletal muscle of humans......Page 145
IV. Mechanisms responsible for activation of the stress response in skeletal muscle during exercise......Page 146
V. Skeletal muscle adapts to reduce the possibility of damage due to oxidative stress following contractile activity......Page 147
VI. The effect of age on skeletal muscle function......Page 150
References......Page 152
I. Introduction......Page 156
III. Cytosolic chaperones and protein targeting to mitochondria......Page 157
IV. The import machinery of the outer membrane......Page 159
V. The import machinery of the inner membrane......Page 160
VI. Translocation from the inner membrane to the matrix......Page 161
VIII. Stress proteins and mitochondrial biogenesis......Page 162
IX. Stress proteins and mitochondrial disease......Page 163
References......Page 164
I. Gender bias......Page 168
II. Overview of heat shock protein biology......Page 169
IV. Gender-specific response to exercise......Page 170
V. Gender-specific regulation of HSP70 with exercise......Page 171
VI. Redox mechanism of HSP induction......Page 172
VIII. Protective potential of HSPs......Page 173
IX. Functional outcomes of the gender-specific HSP response to exercise......Page 174
XI. Significance and impact......Page 175
XII. Limitations and future directions......Page 177
References......Page 178
I. Introduction......Page 184
II. Impact of HSP regulation in multicellular systems......Page 185
A. HSPs in the intracellular environment......Page 187
1. HSP surface expression......Page 188
2. HSP-peptide complexes......Page 190
IV. Examining the HSP-immune modulation dichotomy......Page 191
Acknowledgments......Page 196
References......Page 197
I. Introduction......Page 201
A. Temperature......Page 202
C. Energy metabolism......Page 203
D. Metabolic and stress-related messengers......Page 204
A. Acute exercise response......Page 205
B. Heat shock protein response to training......Page 208
C. Exercise-induced hypoperfusion/ischemia and the heat shock protein response......Page 211
A. Heat shock proteins and exercise-related stress and adaptation......Page 212
B. Heat shock proteins as cytokines/messenger signals......Page 214
References......Page 215