دانلود کتاب Fibrinogen. Proceedings/ Workshop on Fibrinogen. Vol. 4 Fibrin formation and Fibrinolysis: April, 2–3, 1985, London, England

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Preface\nContributors\nContents\nI. Synthesis And Assembly\nA scheme for the intracellular assembly of human fibrinogen\nEvidence that platelet and plasma fibrinogen have the same A-alpha chain gene product\nFibrinopeptide A and the phosphorylation of fibrinogen\nII. Structure and Function\nSize and shape of the fibrinogen molecule: crystalline forms of native and modified human fibrinogen\nThe C-terminal polymerisation domain of fibrinogen\nγ- Chain Crosslinking Of Fibrin At Dd-Trans Contact\nSoluble fibrin contains fibrin polymers of different molecular weight. Ultracentrifugation studies at 37°C\nRelationship of final thickness of fibrin fibers to maximal rate of assembly and to fibrinopeptide B release\nIII. Congenital Variants\nFibrinogen New York 1: The structural, functional, and genetic defects and an hypothesis of the role of fibrin in the regulation of coagulation and fibrinolysis\nFibrinogen Pontoise - a genetically abnormal fibrinogen with defective fibrin polymerisation but normal fibrinopeptide release\nFibrinogen Milano I: Abnormal fibrin polymerization related to a carboxy-terrainal defect of the γ-chain (γ-330 Asp Val)\nFibrinogen \"Bergamo I\" (Λα 16 Arg - Cys): Alternative methods for structure elucidation\nScreening small plasma samples by HPLC for abnormalities of fibrinopeptide release\nIv. Fibrin(ogen) And Fibrinolysis\nOn the role of fibrin in the fibrinolytic system\nIsolation and characterisation of plasmic degradation products of fibrinogen by high-performance liquid chromatography\nThe acceleration of tissue-type plasminogen activator (t-PA)-mediated activation of plasminogen by fibrinogen cyanogen bromide fragments is species specific\nRole of fibrin polymerization in fibrinolysis: Comparison between polymerisable and unpolymerisable fibrins in the potentiating effect of plasminogen activation by tissue-type plasminogen activator (tpA)\nRole of fibrin and its degradation products in the activation of plasminogen by streptokinase and urokinase\nV. Interactions With Cells\nThe role of fibrinogen in platelet aggregation\nPlatelet-associated fibrinogen: Conformational change of fibrinogen induced by its adsorption to platelet-surface\nMigration of cultured endothelial cells in response to fibrinogen\nCharacteristics of the interactions of fibrinogen and soluble fibrin with cultured endothelial cells\nMechanism of fibrin-induced disorganisation of cultured human endothelial cells\nThe fibrinogen: red cell interaction and its influence on blood rheology\nHaemorheologic effects of plasmin and thrombininduced fibrinogen derivatives: An in vitro study\nBinding of human fibrinogen to streptococci and its role in streptococcal pathogenicity\nVI. Assays To Fibrin(ogen) Fragments And Their Use\nDiscrimination between fibrin and fibrinogen by a monoclonal antibody against a synthetic hexapeptide representing the amino-terminus of the alpha-chain of fibrin\nA new enzyme immunoassay of fibrin(ogen) degradation products in plasma using a monoclonal antibody\nFibrin(ogen) degradation products. Determination using a monoclonal anti D neo antibody. Advantages in clinical investigation\nA monoclonal antibody, specific for human fibrinogen and fibrinopeptide A-containing fragments. Its application in an enzyme-immunoassay for fibrinogen degradation products, suitable for use in plasma\nA monoclonal antibody against the CNBr-peptide F-CB3 of the Aα-chain of human fibrinogen\nClinical aspects of fibrin formation and fibrinolysis measured with monoclonal antibodies against D-dimer\nFibrinogen derivatives in acute stroke\nVII. Fibrin(ogen) And Disease Pathology\nTriggering of the extrinsic blood coagulation system\nExtravascular fibrin formation and fibrinolysis in a model of inflammation accompanying cellular hypersensitivity\nExtra-vascular fibrin deposition in cellular hypersensitivity - the role of T lymphocyte-macrophage interactions\nFibrinolytic studies in disorders of connective tissue\nSoluble fibrin/fibrinogen related antigen in human intima in relation to atherogenesis\nFibrinogen as a possible risk factor for IHD in the Caerphilly study\nVIII. Appendix: Data On Fibrinogen\nFibrinogen amino acid sequences\nAuthor Index\nSubject Index