دانلود کتاب Flavonoids and Phenolics (Medicinal Chemistry Lessons From Nature Book 1)

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Cover\nTitle\nCopyright\nEnd User License Agreement\nContents\nForeword\n KEY FEATURES\nPreface\nList of Contributors\nPolyphenols and Flavonoids: Chemical, Pharmacological and Therapeutic Aspects\n Stefania Cesa1,*, Francesco Cairone1 and Celeste De Monte1\n INTRODUCTION\n CHEMICAL STRUCTURES, CLASSIFICATION AND PROPERTIES OF FLAVONOIDS\n Classes of Flavonoids with the B Ring on C2\n Classes of Flavonoids with the B Ring on C3\n Classes of Flavonoids Where the B Ring is Connected to the C Ring Through the 4th Position\n Classes of Open-Chain Flavonoids\n PHARMACOLOGICAL ASPECTS OF POLYPHENOLS AND FLAVONOIDS\n BIOAVAILABILITY AND METABOLISM OF FLAVONOIDS, TOXICOLOGICAL ACTIVITY AND SEMI-SYNTHETIC STRATEGIES\n ADME of Flavonoids\n Factors that Could Affect ADME of Flavonoids\n Toxicity of Flavonoids\n Strategies for a Better Investigation of Flavonoids Properties\n CONCLUSION\n CONSENT FOR PUBLICATION\n CONFLICT OF INTEREST\n ACKNOWLEDGEMENTS\n REFERENCES\nRecent Development of Hybrids and Derivatives of Resveratrol in Neurodegenerative Diseases\n Barbara De Filippis1,* and Marialuigia Fantacuzzi1\n INTRODUCTION\n MULTITARGET ANALOGUES OF RSV\n Hybrids of RSV\n Derivatives of RSV\n Schiff Base Derivatives of RSV\n CONCLUDING REMARKS\n ABBREVIATIONS:\n CONSENT FOR PUBLICATION\n CONFLICT OF INTEREST\n ACKNOWLEDGEMENTS\n REFERENCES\nBiological Activities of Synthetic Derivatives of Xanthones: An Update (2016-2020)\n Cristina Scarpecci1 and Sara Consalvi1,*\n INTRODUCTION\n XANTHONE SYNTHETIC DERIVATIVES FOR CANCER THERAPY\n Caged Xanthones (CXs)\n Mangostin Analogs\n Carboxyxanthones\n Dihydroxyxanthones\n N-Xanthone Benzensulphonamides\n Dioxygenated Xanthones\n Xanthones Bearing Long Side Chains\n ANTIBACTERIAL XANTHONE SYNTHETIC DERIVATIVES\n Amphiphilic Xanthones\n Amino Acid-Conjugated Xanthones\n Miscellaneous Compounds\n ANTIFUNGAL XANTHONE SYNTHETIC DERIVATIVES\n ANTIMALARIAL XANTHONE SYNTHETIC DERIVATIVES\n XANTHONE SYNTHETIC DERIVATIVES AS ANTI-INFLAMMATORY AGENTS\n ANTI-ALZHEIMER XANTHONE SYNTHETIC DERIVATIVES\n XANTHONE SYNTHETIC DERIVATIVES AS Α-GLUCOSIDASE INHIBITORS\n CONCLUDING REMARKS\n CONSENT FOR PUBLICATION\n CONFLICT OF INTEREST\n ACKNOWLEDGEMENT\n REFERENCES\nCombretastatin Derivatives as Tubulin Inhibitors: A Fascinating Journey from Nature to Drug Discovery Strategies\n Alessandra Ammazzalorso1,* and Trond Vidar Hansen2\n INTRODUCTION\n INSIGHTS ON MECHANISM OF ACTION OF COMBRETASTATINS\n Development of Combretastatin Prodrugs\n Fosbretabulin, Ombrabulin and Oxi4503\n Combretastatin Prodrugs With Improved Drug Delivery Ability\n Bioreductive Prodrugs of Combretastatins\n Photoresponsive Hybrid Prodrugs of Combretastatins\n DEVELOPMENT OF COMBRETASTATIN DERIVATIVES\n Combretastatin Derivatives Obtained by Bridge Modifications\n Carbocyclic Derivatives\n Heterocyclic Derivatives\n RECENT ADVANCES IN DRUG DELIVERY SYSTEMS OF COMBRETASTATIN\n CONCLUDING REMARKS\n ABBREVIATIONS\n CONSENT FOR PUBLICATION\n CONFLICT OF INTEREST\n ACKNOWLEDGEMENT\n REFERENCES\nNatural Flavonoid and Chalcone Scaffolds as Leads for Synthetic Antitubercular Agents\n Federico Appetecchia1, Mariangela Biava1 and Giovanna Poce1,*\n INTRODUCTION\n FLAVONOIDS\n Chalcones\n Simple-substituted Chalcones\n Heteroaryl and Hybrid Chalcones\n CONCLUDING REMARKS\n CONSENT OF PUBLICATION\n CONFLICT OF INTEREST\n ACKNOWLEDGMENT\n REFERENCES\nIn Silico Approaches to Naturally Existing Chalcones and Flavonoids on Mao Inhibitory Action: A Boon to CNS Drug Discovery\n Arafa Musa1,2, Della Grace Thomas Parambi3, Mutairah Shaker Alshammari4, Rania Bakr3, Mohammed A. Abdelgawad3,5, Dibya Sundar Panda6, Manoj Kumar Sachidanandan7, Vaishnav Bhaskar8, Leena K. Pappachen8 and Bijo Mathew8,*\n INTRODUCTION\n CHALCONES\n Prenylated Chalcone: Xanthoangelol and 4-Hydroxyderricin\n Resveratrol\n Dihydrochalcones\n Flavonoids\n Quercetin\n Xanthones\n Homoisoflavonoids\n Thioflavones\n Sideritis Flavonoids\n Studies on Apigenin, Kaempferol, Quercetin and Luteolin\n PRENYLAPIGENIN\n Bavachinin and Bavachin\n Genistein\n Phytochemicals from Clitoria Ternatea\n O-Methylated Flavonoids\n CONCLUDING REMARKS\n CONSENT FOR PUBLICATION\n CONFLICT OF INTEREST\n ACKNOWLEDGEMENTS\n REFERENCES\nLignins and Lignans – Recent Developments and Trends Regarding their Pharmaceutical Properties\n Luc Zongo1 and Heiko Lange2,*\n INTRODUCTION\n LIGNIN\n Biosynthesis and Structural Features of Lignins\n Isolation of Lignins\n Lignin Fractionation\n LIGNANS\n Biosynthesis and Structural Features of Lignans\n ANALYTICAL TOOLS FOR ANALYSES OF LIGNINS AND LIGNANS\n Fourier-Transform Infrared Spectroscopy and Raman Spectroscopy\n NMR Spectroscopy-Based Analysis Methods\n Size Exclusion and Gel Permeation Chromatographic Methods\n Mass Spectrometry Methods\n Anti-Oxidant Activity Assays\n LIGNINS FOR USE IN PHARMACEUTICAL AREA\n Lignin as Source of Pharmaceutical Activity\n LIGNIN AS MATERIAL FOR MICRO- AND NANOSTRUCTURES FOR PHARMACEUTICAL USE\n Lignin-Containing Film Preparations for Pharmaceutical Applications\n NANOPARTICLES\n Micro- and Nanoscaled Core-shell Structures\n Incorporation of Actives in Lignin Particle and Lignin Capsule Structures\n Entrapment Vs. Encapsulation Vs. Adsorption\n Covalent and Electrostatic Surface Functionalisation\n PHARMACEUTICAL PROPERTIES OF LIGNANS\n Dietary Value of Lignans in Health Promotion\n Antiaging Potential of Lignans\n Anti-Inflammatory Properties of Lignans\n Anticancer Properties of Lignans\n Antibiotic Properties of Lignans\n Antiviral Properties of Lignans\n Hepatoprotective Effects of Lignans\n The Neuroprotective Effects of Lignans\n The Physicochemical Properties of Lignans in Drug Design\n CONCLUDING REMARKS AND FUTURE PERSPECTIVES\n CONSENT FOR PUBLICATION\n CONFLICT OF INTEREST\n ACKNOWLEDGEMENT\n REFERENCES\nSemisynthetic Resveratrol-derived Systems: A Synergism between Nature and Organic Synthesis\n Antonella Capperucci1 and Damiano Tanini1,*\n INTRODUCTION\n RESVERATROL ETHERS AND RELATED DERIVATIVES\n Resveratryl Esters and Related Derivatives\n Selenium-containing Resveratrol Derivatives\n Resveratrol-Derived Hybrids and Other Conjugates\n CONCLUSION\n CONFLICT OF INTEREST\n ACKNOWLEDGEMENT\n CONSENT OF PUBLICATION\n REFERENCES\nAurone Scaffold and Structural Analogues for the Development of Monoamine Oxidase (MAO) Inhibitors\n Paolo Guglielmi1, Virginia Pontecorvi1,* and Atilla Akdemir2\n INTRODUCTION\n AURONES AND THEIR STRUCTURAL-RELATED COMPOUNDS\n Aurones\n Indanone and Tetralone Derivatives\n Homoisoflavonoids Derivatives (3-Benzylidenechroman-4-ones)\n CONCLUSION\n CONSENT FOR PUBLICATION\n CONFLICT OF INTEREST\n ACKNOWLEDGEMENT\n REFERENCES\nCoumarins as Carbonic Anhydrase Inhibitors\n Claudiu T. Supuran1,*\n CARBONIC ANHYDRASE INHIBITORS AND ACTIVATORS\n COUMARINS WITH CA INHIBITORY ACTION\n Natural Product Coumarins\n Synthetic Coumarins\n Other Drug Design Studies using Coumarins as Lead Molecules\n CONCLUSIONS\n CONSENT FOR PUBLICATION\n CONFLICT OF INTEREST\n ACKNOWLEDGEMENTS\n REFERENCES\nPhenols and Polyphenols as Carbonic Anhydrase Inhibitors\n Alessandro Bonardi1, Claudiu T. Supuran1 and Alessio Nocentini1,*\n PHENOLS AND POLYPHENOLS\n Carbonic Anhydrases\n CA Inhibition Mechanism of Phenol Derivatives\n Phenolic Derivatives Inhibit Human CAs\n Synthetic/Semisynthetic Phenolic Derivatives as Hcas Inhibitors\n Natural and Synthetic/Semisynthetic Phenols Inhibit Carbonic Anhydrases From Bacteria, Fungi, Protozoa, And Diatoms\n In Silico Studies of the Binding Mode of Phenolic Derivatives to CA Isoforms\n CONCLUSION\n CONSENT FOR PUBLICATION\n CONFLICT OF INTEREST\n ACKNOWLEDGEMENT\n REFERENCES\nThe Role of Flavonoids and other Selected (Poly) Phenols in Cancer Prevention and Therapy: A Focus on Epigenetics\n Melissa D’Ascenzio1,*\n INTRODUCTION\n Chemoprevention and the Epigenetic Mechanisms Associated with Chronic Diseases\n EPIGENETIC MARKS AND EPIGENETIC PROTEINS\n DNA Methyltransferases\n Histone Acetyl Transferases (Hats) and Histone Deacetylases (Hdacs)\n Histone Methyl Transferases (Hmts)\n Other Post-Translational Modifications\n FLAVONOIDS AS EPIGENETIC MODULATORS IN CHEMOPREVEN-TION AND CANCER THERAPY\n FLAVONOLS, FLAVONES, ISOFLAVONES, AND ANTHOCYANINS\n Flavonols: Quercetin and Kaempferol\n Flavones: Apigenin, Luteolin and Chrysin\n Isoflavones: Genistein and Daidzein\n Anthocyanins\n Flavanols: Catechins from Green Tea\n CURCUMIN AND CURCUMINOIDS\n RESVERATROL AND OTHER STILBENE DERIVATIVES\n CONCLUDING REMARKS\n CONSENT FOR PUBLICATION\n CONFLICT OF INTEREST\n ACKNOWLEDGEMENTS\n REFERENCES\nSubject Index\nBack Cover