دانلود کتاب Formulation and optimization of polymeric nano drug delivery system of acyclovir using 3(2) full factorial design

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Статья. Опубликована в International Journal of PharmTech Research, Vol.1, No.3, pp 644-653, July-Sept 2009Acyclovir is an antiviral drug, used for treatment of herpes simplex virus infections with an oral
bioavailability of only 10 to 20 % (limiting absorption in GIT to duodenum and jejunum),half life about 3 hrs, soluble only at acidic pH (pKa 2.27). Polymeric nano drug delivery systems of acyclovir have been designed and optimized using 3² full factorial design. Poly (lactic-co-glycolic acid) (PLGA) (50:50) was used as polymers and Pluronic F68 used as stabilizer. Nanoparticles were prepared by solvent deposition method.From the preliminary trials, the constraints for independent variables X1 (amount of PLGA) and X2 (amount of Pluronic F68) have been fixed. The derived polynomial equations for Particle size and % drug entrapment were verified by check point formulation. The prepared formulations were further evaluated for drug content, in vitro drug release pattern, and short-term stability and drug-excipient interactions.The application of factorial design gave a statistically systematic approach for the formulation and optimization of nanoparticles with desired particle size and high entrapment efficiency. Drug: polymer ratio and concentration of stabilizer were found to influence the particle size and entrapment efficiency of acyclovir loaded PLGA nanoparticles. The release was found to follow first order release kinetics with fickian diffusion mechanism. for all batches. These preliminary results indicate that acyclovir loaded PLGA nanoparticles could be effective in sustaining drug release for a prolonged period.