دانلود کتاب Genetics. Analysis and Principles

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Front Cover
Title Page
Copyright Page
Brief Contents
Table of Contents
Preface
A Visual Guide to Genetics: Analysis & Principles
PART I: INTRODUCTION
1 OVERVIEW OF GENETICS
1.1 The Relationship Between Genes and Traits
1.2 Fields of Genetics
PART II: PATTERNS OF INHERITANCE
2 MENDELIAN INHERITANCE
2.1 Mendel’s Laws of Inheritance
2.2 Probability and Statistics
3 REPRODUCTION AND CHROMOSOME TRANSMISSION
3.1 General Features of Chromosomes
3.2 Cell Division
3.3 Sexual Reproduction
3.4 The Chromosome Theory of Inheritance and Sex Chromosomes
4 EXTENSIONS OF MENDELIAN INHERITANCE
4.1 Inheritance Patterns of Single Genes
4.2 Gene Interactions
5 NON-MENDELIAN INHERITANCE
5.1 Maternal Effect
5.2 Epigenetic Inheritance
5.3 Extranuclear Inheritance
6 GENETIC LINKAGE AND MAPPING IN EUKARYOTES
6.1 Linkage and Crossing Over
6.2 Genetic Mapping in Plants and Animals
6.3 Genetic Mapping in Haploid Eukaryotes
6.4 Mitotic Recombination
7 GENETIC TRANSFER AND MAPPING IN BACTERIA AND BACTERIOPHAGES
7.1 Genetic Transfer and Mapping in Bacteria
7.2 Intragenic Mapping in Bacteriophages
8 VARIATION IN CHROMOSOME STRUCTURE AND NUMBER
8.1 Variation in Chromosome Structure
8.2 Variation in Chromosome Number
8.3 Natural and Experimental Ways to Produce Variations in Chromosome Number
PART III: MOLECULAR STRUCTURE AND REPLICATION OF THE GENETIC MATERIAL
9 MOLECULAR STRUCTURE OF DNA AND RNA
9.1 Identification of DNA as the Genetic Material
9.2 Nucleic Acid Structure
10 CHROMOSOME ORGANIZATION AND MOLECULAR STRUCTURE
10.1 Viral Genomes
10.2 Bacterial Chromosomes
10.3 Eukaryotic Chromosomes
11 DNA REPLICATION
11.1 Structural Overview of DNA Replication
11.2 Bacterial DNA Replication
11.3 Eukaryotic DNA Replication
PART IV: MOLECULAR PROPERTIES OF GENES
12 GENE TRANSCRIPTION AND RNA MODIFICATION
12.1 Overview of Transcription
12.2 Transcription in Bacteria
12.3 Transcription in Eukaryotes
12.4 RNA Modification
13 TRANSLATION OF mRNA
13.1 The Genetic Basis for Protein Synthesis
13.2 Structure and Function of tRNA
13.3 Ribosome Structure and Assembly
13.4 Stages of Translation
14 GENE REGULATION IN BACTERIA AND BACTERIOPHAGES
14.1 Transcriptional Regulation
14.2 Translational and Posttranslational Regulation
14.3 Riboswitches
14.4 Gene Regulation in the Bacteriophage Reproductive Cycle
15 GENE REGULATION IN EUKARYOTES
15.1 Regulatory Transcription Factors
15.2 Chromatin Remodeling, Histone Variation, and Histone Modification
15.3 DNA Methylation
15.4 Insulators
15.5 Regulation of RNA Processing, RNA Stability, and Translation
16 GENE MUTATION AND DNA REPAIR
16.1 Consequences of Mutation
16.2 Occurrence and Causes of Mutation
16.3 DNA Repair
17 RECOMBINATION AND TRANSPOSITION AT THE MOLECULAR LEVEL
17.1 Homologous Recombination
17.2 Site-Specific Recombination
17.3 Transposition
PART V: GENETIC TECHNOLOGIES
18 RECOMBINANT DNA TECHNOLOGY
18.1 Gene Cloning Using Vectors
18.2 Polymerase Chain Reaction
18.3 DNA Libraries and Blotting Methods
18.4 Methods for Analyzing DNA- and RNA- Binding Proteins
18.5 DNA Sequencing and Site-Directed Mutagenesis
19 BIOTECHNOLOGY
19.1 Uses of Microorganisms in Biotechnology
19.2 Genetically Modified Animals
19.3 Reproductive Cloning and Stem Cells
19.4 Genetically Modified Plants
19.5 Human Gene Therapy
20 GENOMICS I: ANALYSIS OF DNA
20.1 Overview of Chromosome Mapping
20.2 Cytogenetic Mapping Via Microscopy
20.3 Linkage Mapping Via Crosses
20.4 Physical Mapping Via Cloning
20.5 Genome-Sequencing Projects
21 GENOMICS II: FUNCTIONAL GENOMICS, PROTEOMICS, AND BIOINFORMATICS
21.1 Functional Genomics
21.2 Proteomics
21.3 Bioinformatics
PART VI: GENETIC ANALYSIS OF INDIVIDUALS AND POPULATIONS
22 MEDICAL GENETICS AND CANCER
22.1 Inheritance Patterns of Genetic Diseases
22.2 Detection of Disease-Causing Alleles
22.3 Prions
22.4 Genetic Basis of Cancer
23 DEVELOPMENTAL GENETICS
23.1 Overview of Animal Development
23.2 Invertebrate Development
23.3 Vertebrate Development
23.4 Plant Development
23.5 Sex Determination in Animals and Plants
24 POPULATION GENETICS
24.1 Genes in Populations and the Hardy-Weinberg Equation
24.2 Factors That Change Allele and Genotype Frequencies in Populations
24.3 Sources of New Genetic Variation
25 QUANTITATIVE GENETICS
25.1 Quantitative Traits
25.2 Polygenic Inheritance
25.3 Heritability
26 EVOLUTIONARY GENETICS
26.1 Origin of Species
26.2 Phylogenetic Trees
26.3 Molecular Evolution
26.4 Evo-Devo: Evolutionary Developmental Biology
Appendix A: Experimental Techniques
Appendix B: Solutions to Even-Numbered Problems
Glossary
Credits
Index