دانلود کتاب Hemoglobin and Oxygen Binding

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Front Matter....Pages i-xxviii
Front Matter....Pages 1-1
Heme—Iron Ligand Binding....Pages 4-11
Crystal Structure of Oxymyoglobin at 1.6 Å Resolution....Pages 13-17
Structure of Deoxy- and Oxy-Erythrocruorin and Related Ligand States at 1.4 Å Resolution....Pages 19-24
Structural Results for Model Compounds of Significance in Hemoglobin Chemistry....Pages 25-35
“Mercaptan-Tail” Porphyrins....Pages 37-40
Crystallographic Refinement of Macromolecules....Pages 41-50
Dependence of Axial Ligand Force Constants upon Globin Structure in Hemoglobin and Myoglobin....Pages 51-61
Spin Unpairing in Oxyand Carbonmonoxy-Hemoglobins....Pages 63-67
Theoretical Calculation on Heme-Oxygen Bonding in Myoglobin and Hemoglobin....Pages 69-73
Theoretical Studies of Some Metalloporphyrins of Unusual Structure....Pages 75-81
The Electronic Spectra of Hb, HbO2, and HbCO....Pages 83-89
Nmr and Esr of Myoglobin Crystals Using Magnetic Ordering....Pages 91-95
Discussion for Session I Heme-Oxygen Bonding....Pages 97-110
Front Matter....Pages 111-111
Control of Oxygen Affinity of the Heme by the Structure of the Globin in Hemoglobin....Pages 113-118
Deoxy- and Liganded-Hemoglobin....Pages 119-123
Structure of Human Deoxy Cobalt Hemoglobin....Pages 125-126
Structure—Function Relationships in Carbonmonoxy β4 Hemoglobin....Pages 127-133
The Relation of Hemoglobin Ligand Binding Kinetics to Structure....Pages 135-140
1H Nmr Studies of Cooperative Oxygenation of Normal Human Adult Hemoglobin....Pages 141-149
The Effect of DPG and IHP on the Relative Thermodynamic Affinity for CO of the Subunits of Rabbit Hemoglobin....Pages 151-154
Front Matter....Pages 111-111
A Novel 13C Nmr Probe for Heme Proteins....Pages 155-158
Cooperativity in Methemoglobin and Its Implications for the Mechanism of Cooperative Oxygenation....Pages 159-163
The Thermodynamic Nature of Inositol Hexaphosphate Binding to Hemoglobin A....Pages 165-168
Thermodynamic Aspects of Homotropic and Heterotropic Ligand Binding by Hemoglobin....Pages 169-175
Effect of Chemical Modification of Heme on the O2- and CO-Binding Properties of Hemoglobin and Myoglob....Pages 177-184
Structure Change Energy....Pages 185-190
Concept of a Heme-Binding Domain in Relation to Gene Structure....Pages 191-197
Subunit Inequivalence in Allosteric Constraints of Prosthetic Groups in T-State Hemoglobins....Pages 199-204
The Two-State Model of Hemoglobin....Pages 205-209
Strain and Electrostatic Contributions to Cooperativity in Hemoglobin....Pages 211-215
Resonance Raman Evidence for a Stretched Fe-Nε (His F8) Bond in the T-Structure Deoxyhemoglobin....Pages 217-222
An Electronic Interaction Model for Hemoglobin Cooperativity....Pages 223-229
Electrostatic Interactions Associated with Effector Binding to Hemoglobin....Pages 231-241
Stability of the α1β2 Contact in Oxy and Deoxy Human Hemoglobins....Pages 243-248
A 1H Nmr Investigation of the Role of Histidyl Residues in the Alkaline Bohr Effect of Normal Human Adult Hemoglobin....Pages 249-256
Effects of Anions and CO2 on the Dissociation of Liganded-Human Hemoglobin and Human Hemoglobin Variants....Pages 257-261
Chloride Binding to Hemoglobin As Studied By Nuclear Magnetic Quadrupole Relaxation....Pages 263-267
Conformational Transitions in Carp Hemoglobin at Low pH....Pages 269-275
Enhancement of the O2 Release Capacity and of the Bohr-Effect of Human Red Blood Cells after Incorporation of Inositol Hexaphosphate by Fusion with Effector-Containing Lipid Vesicles....Pages 277-282
Interaction of Hemoglobin with the Anion Transport Protein of the Erythrocyte Membrane....Pages 283-289
Front Matter....Pages 111-111
Sickle Cell Hemoglobin Polymers Bind Oxygen Noncooperatively....Pages 291-294
The Effect of Oxygen Saturation on the Intracellular Polymerization of Sickle Hemoglobin....Pages 295-299
Modification of Hemoglobin Structure and Function by Nonenzymatic Glycosylation....Pages 301-305
Discussion for Session II Origins of Cooperative Oxygen Binding by Hemoglobin....Pages 307-319
Front Matter....Pages 320-320
Dynamics of Ligand Binding....Pages 321-327
Initial Steps in the Dissociation of MbO2 and MbCO....Pages 329-332
Dynamics of Carboxyhemoglobin Photolysis....Pages 333-338
Ultrafast CO Rebinding Following Nanosecond Laser Photolysis of Human HbCO in Viscous Solvents at Low Temperature....Pages 339-343
Absorption Spectra of HbO2 and Hb after Picosecond Photolysis....Pages 345-350
Spectral Changes of Co-Hemoglobin and Its Isolated Subunits Observed after Nanosecond Laser Photolysis....Pages 351-354
Picosecond Resonance Raman Spectroscopic Evidence for Excited-State Spin Conversion in Carbonmonoxy-Hemoglobin Photolysis....Pages 355-361
Solvent Viscosity and the Dynamics of Dioxygen Binding to Myoglobin....Pages 363-369
Possible Reaction Paths for Ligand Binding to Human Hemoglobin....Pages 371-375
Interactions of Solvent with the Heme Region of Methemoglobin and Fluoro-Methemoglobin....Pages 377-385
Kinetic Criteria for Definition of T-States of Hemoglobin in Solution....Pages 387-391
Kinetic Mechanisms of Ligand Binding to Heme Proteins....Pages 393-398
Kinetics of Oxygen and CO Binding to Isolated Chains of Carp Hemoglobin and to Carp-Human (Mermaid) Hybrid Hemoglobins....Pages 399-402
The Effect of the 146β Histidine on the pH Dependence of the R State of Human Hemoglobin....Pages 403-407
Thermodynamics and Kinetics of the Reactions of Trout Hb I with O2 and CO....Pages 409-412
Conformational Dynamics of Hemoglobin in the Crystal and in Solution....Pages 413-418
Front Matter....Pages 320-320
Heme Orientational Heterogeneity in Hemoproteins as Detected by Proton Nmr....Pages 419-424
Steric Effects in Hemoprotein Reactivities....Pages 425-433
The Mobile Distal Histidine of Leghemoglobin....Pages 435-441
Diffusive Transport of Oxygen Through Proteins and Membranes Quantified by Fluorescence Quenching....Pages 443-448
Kinetics of Oxygen Reactions within Single Erythrocytes....Pages 449-452
Discussion for Session III Dynamics of Oxygen Binding....Pages 453-467
After Dinner Program: To Honor Max Perutz....Pages 469-479
Back Matter....Pages 481-486