دانلود کتاب Hepatitis C Virus: From Laboratory to Clinic (Biomedical Research Topics S.)

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Front......Page 1
Contents......Page 9
Preface......Page 11
Foreword......Page 13
Abbreviations......Page 15
Part I - Basic principles......Page 17
1 - Background......Page 19
2 - The virus......Page 35
3 - Epidemiology and transmission......Page 57
4 - Natural history of infection......Page 71
5 - Pathogenesis of infection......Page 81
6 - Hepatitis C and hepatocellular carcinoma......Page 101
7 - Hepatitis C and autoimmune diseases......Page 109
8 - Clinical aspects of the disease......Page 113
9 - Current therapeutic approaches......Page 117
10 - Nonstructural protein 5A and interferon resistance......Page 123
Part II - Recent advances......Page 127
11 - Cell types supporting hepatitis C replication in vivo and in vitro......Page 129
12 - Understanding the natural history of hepatitis C......Page 133
13 - Animal models......Page 135
14 - Vaccine research......Page 139
Part III - Experimental approaches......Page 143
15 - New systems to understand hepatitis C biology......Page 145
16 - New antiviral screening assays......Page 147
17 - Antiviral gene therapy......Page 151
Part IV - Protocols and techniques......Page 157
18 - Sample collection, preparation, and storage......Page 159
19 - Hepatitis C RNA in blood and tissue samples......Page 161
20 - Hepatitis C genotypes and quasispecies......Page 165
21 - Replication of hepatitis C in tissue culture......Page 167
22 - Enzyme activities of nonstructural protein 3......Page 169
23 - Characterization of nonstructural protein 5B......Page 173
Part V - Some outstanding questions and emerging areas for investigation......Page 175
24 - Outstanding issues......Page 177
25 - Prospects......Page 191
References......Page 193
Index......Page 265