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Front Matter,Copyright,Dedication,Hepatic Cirrhosis,List of Contributors,Foreword,AcknowledgmentsEntitled to full textSection I: IntroductionChapter 1 - The Liver: General Aspects and Epidemiology, Pages 3-22, P. Muriel
Chapter 2 - Structure and Ultrastructure of the Normal and Diseased Liver, Pages 23-44, V. Tsutsumi, T. Nakamura, T. Ueno, T. Torimura, J. Aguirre-García
Chapter 3 - Hepatic Apoptosis and Necrosis: Mechanisms and Clinical Relevance, Pages 47-60, F. Xia, L. Zeng, X.R. Yao, B.J. Zhou
Chapter 4 - Autoimmune Hepatitis, Pages 61-85, A.J. Czaja
Chapter 5 - Pathogenesis of Idiosyncratic Drug Induced Liver Injury, Pages 87-100, L. Dara, Z.-X. Liu, N. Kaplowitz
Chapter 6 - Acetaminophen, Pages 101-112, A. Ramachandran, H. Jaeschke
Chapter 7 - Liver Regeneration, Pages 113-123, A. Katoonizadeh
Chapter 8 - Nitric Oxide in Liver Ischemia–Reperfusion Injury, Pages 125-127, P. Fu, W. Li
Chapter 9 - The Immune System and Viral Hepatitis, Pages 129-139, N.A. Fierro, K. Gonzalez-Aldaco, S. Roman, A. Panduro
Chapter 10 - The Pathophysiology of Alcoholic Liver Disease∗, Pages 141-157, S.W. French
Chapter 11 - Cytokines in Steatohepatitis, Pages 159-168, L. Hammerich, F. Tacke
Chapter 12 - Redox Signaling in NASH, Pages 169-180, A. Takaki, D. Uchida, K. Yamamoto
Chapter 13 - Amebic Liver Abscess, Pages 181-186, A. Martínez-Palomo, M. Espinosa-Cantellano, G.R. Tsutsumi, V. Tsutsumi
Chapter 14 - Role of Cytokines and Reactive Oxygen Species in the Amebic Liver Abscess Produced by Entamoeba histolytica, Pages 187-197, J. Pacheco-Yépez, M. Martínez-Castillo, A. Cruz-Baquero, J. Serrano-Luna, M. Shibayama
Chapter 15 - Epigenetics in Liver Disease: Involvement of Oxidative Stress, Pages 199-211, J. Mann
Chapter 16 - Role of Oxidative and Nitrosative Stress in Hepatic Fibrosis, Pages 213-224, T.T. Thuy le, T.T.V. Thuy, H. Hai, N. Kawada
Chapter 17 - Oxidative and Nitrosative Stress in Chronic Cholestasis, Pages 225-237, I. Grattagliano, P.J. Oliveira, L. Vergani, P. Portincasa
Chapter 18 - Cholestasis, Contraceptives, and Free Radicals, Pages 239-258, E. Fernández-Martínez
Chapter 19 - Is Human Cirrhosis a Reversible Disease?, Pages 259-265, D. Kershenobich, D.G. Gutiérrez-Reyes
Chapter 20 - Obesity and Hepatocellular Carcinoma, Pages 267-277, W. Xu, J. Yu
Chapter 21 - Oxidative Stress as a Mechanism for Hepatocellular Carcinoma, Pages 279-287, M. Tarocchi, A. Galli
Chapter 22 - Nuclear Factor-Kappa B Actions During the Development of Hepatocellular Carcinoma, Pages 289-293, S. Maeda, W. Shibata
Chapter 23 - The Role of Senescence in Hepatic Diseases, Pages 295-308, R. Pacheco-Rivera, J. Arellanes-Robledo, M.C. García de León, M. Shibayama, J. Serrano-Luna
Chapter 24 - Exercise, Liver Steatosis, and Free Radicals, Pages 309-322, I.O. Gonçalves, M.J. Martins, J. Beleza, A. Ascensão, J. Magalhães
Chapter 25 - The Metabolic Syndrome, Oxidative Stress, and the Liver, Pages 323-329, P. Almeda-Valdés, N.E. Aguilar-Olivos, M. Uribe, N. Méndez-Sánchez
Chapter 26 - Liver Diseases in the Elderly, Pages 331-339, K. Tajiri, Y. Shimizu
Chapter 27 - Cytokines in Hepatic Injury, Pages 341-354, H. Fukui
Chapter 28 - Nrf2: A Key Regulator of Redox Signaling in Liver Diseases, Pages 355-374, K.M. Kim, S.H. Ki
Chapter 29 - Redox Regulation by HGF/c-Met in Liver Disease, Pages 375-387, L.E. Gómez-Quiroz, M.C. Gutiérrez-Ruiz, J.U. Marquardt, V.M. Factor, S.S. Thorgeirsson
Chapter 30 - Hepatic Metabolism in Liver Health and Disease, Pages 391-400, X. Liu, H. Wang, X. Liang, M.S. Roberts
Chapter 31 - Cytochrome P450 and Oxidative Stress in the Liver, Pages 401-419, A.I. Cederbaum
Chapter 32 - Drug Hepatic Clearance in Spinal Cord Injury, Pages 421-424, P. García-López, L. Cruz-Antonio, G. Guízar-Sahagún, G. Castañeda-Hernández
Chapter 33 - Complications of Cirrhosis: Introduction, Pages 427-433, P. Muriel, E. Fernández-Martínez, S. Montes
Chapter 34 - Portal Hypertension—Molecular Mechanisms, Pages 435-449, J.D. Vorobioff, R.J. Groszmann
Chapter 35 - Gastroesophageal Varices, Pages 451-473, M. Fernandez, J.G. Abraldes
Chapter 36 - Ascites, Pages 475-484, G. Garcia-Tsao
Chapter 37 - Reactive Nitrogen and Oxygen Species in Hepatic Encephalopathy, Pages 485-500, S. Rivera-Mancía, L.A. Tristán-López, S. Montes
Chapter 38 - Hepatorenal Syndrome, Pages 501-510, I. Graupera, E. Solà, P. Ginès
Chapter 39 - Hepatopulmonary Syndrome and Portopulmonary Hypertension, Pages 511-526, S. Raevens, I. Colle
Chapter 40 - Experimental Models of Liver Damage Mediated by Oxidative Stress, Pages 529-546, P. Muriel, E. Ramos-Tovar, G. Montes-Páez, L.D. Buendía-Montaño
Chapter 41 - Monitoring of Liver Fibrogenesis and Biochemical Diagnosis of Fibrosis, Pages 547-561, O.A. Gressner, A.M. Gressner
Chapter 42 - In Vitro Models of HCC, Pages 563-579, J. Arellanes-Robledo, C. Hernández, J. Camacho, J.I. Pérez-Carreón
Chapter 43 - The Liver, Oxidative Stress, and Antioxidants, Pages 583-604, S. Casas-Grajales, P. Muriel
Chapter 44 - Herbal Drugs on the Liver, Pages 605-620, C. Girish, S.C. Pradhan
Chapter 45 - Silymarin for Liver Disease, Pages 621-631, L. Abenavoli, N. Milic
Chapter 46 - Naringenin and the Liver, Pages 633-651, E. Hernández-Aquino, P. Muriel
Chapter 47 - Antioxidant, Antiinflammatory, and Antifibrotic Properties of Quercetin in the Liver, Pages 653-674, L.F. Vázquez-Flores, S. Casas-Grajales, E. Hernández-Aquino, E.E. Vargas-Pozada, P. Muriel
Chapter 48 - Coffee and the Liver, Pages 675-685, J. Arauz, E. Ramos-Tovar, P. Muriel
Chapter 49 - Hepatoprotective Properties of Curcumin, Pages 687-704, K. Reyes-Gordillo, R. Shah, M.R. Lakshman, R.E. Flores-Beltrán, P. Muriel
Chapter 50 - Retinoids in Liver Function, Pages 705-713, G. Shiota
Chapter 51 - Stevia as a Putative Hepatoprotector, Pages 715-727, E. Ramos-Tovar, P. Muriel
Chapter 52 - Are N-Acetylcysteine and Resveratrol Effective Treatments for Liver Disease?, Pages 729-742, E. Chávez, M. Galicia-Moreno, P. Muriel
Chapter 53 - Does Nutrition Matter in Liver Disease?, Pages 743-759, E. Ramos-Tovar, P. Muriel
Chapter 54 - One-Carbon Metabolism in Liver Health and Disease, Pages 761-765, J.M. Mato, M.L. Martínez-Chantar, M. Noureddin, S.C. Lu
Chapter 55 - Ursodeoxycholic Acid for the Treatment of Liver Diseases, Pages 767-779, J.-Y. Wang, S.-D. Wu
Chapter 56 - Current Treatment of Chronic Hepatitis C, Pages 781-789, P. Ferenci
Chapter 57 - An Adenosine Derivative Compound as a Hepatoprotective Agent, Pages 791-798, V. Chagoya de Sánchez, M. del Pilar Cabrales-Romero, G. Velasco-Loyden
Chapter 58 - Nitric Oxide and the Liver, Pages 799-816, P.A. Loughran, L. Xu, T.R. Billiar
Chapter 59 - Repopulation of Cirrhotic Liver by Hepatic Stem/Progenitor Cells: A Promising Strategy Alternative to Liver Transplantation, Pages 817-836, A.A. Khan, S.K. Vishwakarma, A. Bardia, M.A. Habeeb, M. Dhayal
Chapter 60 - Gene Therapy for Liver Disease, Pages 837-851, R.N. Aravalli
Chapter 61 - Role of Oxidative Stress in Liver Transplantation, Pages 853-868, A. Casillas-Ramírez, M.B. Jiménez-Castro, A.Y. Rocha-Sánchez, H.Y. Martínez-Padrón, J. Gracia-Sancho, C. Peralta
Index, Pages 869-881