دانلود کتاب Lung Biology in Health & Disease Volume 201 Lung Surfactant Function and Disorder

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Front cover......Page 1
Introduction......Page 14
References......Page 15
Preface......Page 16
Contributors......Page 20
Contents......Page 24
Composition, Structure, and Function......Page 32
I. Introduction......Page 34
II. Composition of Surfactant Phospholipid Molecular Species in the Adult Lungs......Page 37
IV. Molecular Species of Phospholipid During Postnatal Development......Page 40
V. Modification of Surfactant Phospholipid Molecular Species in Disease States......Page 41
References......Page 43
2 New Insights into the Thermal Dynamics of the Surfactant System from Warm and Cold Animals......Page 48
I. Introduction......Page 49
II. Temperature and the Biophysical Properties of Surfactant......Page 53
III. Temperature and Surfactant Composition......Page 63
IV. Temperature and Control of Surfactant Secretion......Page 72
References......Page 80
I. Introduction......Page 90
II. Structure/Function Relationship......Page 93
III. SP-A Functions......Page 100
IV. Concluding Remarks......Page 108
References......Page 109
4 Receptors and Ligands for Collectins Surfactant Proteins A and D......Page 118
I. Introduction......Page 119
II. Collectins and Related Proteins......Page 120
V. Structure of SP-A and SP-D......Page 122
VI. Ligands for SP-A and SP-D......Page 124
VII. Cells and Receptors......Page 130
VIII. Summary and Future Directions......Page 140
References......Page 141
I. Introduction......Page 156
II. Evolutionary Origin of Hydrophobic Pulmonary Surfactant Proteins......Page 157
III. Biological vs. Clinical Engineering of Pulmonary Surfactant......Page 158
IV. Structure– Function Relationships of SP-B......Page 159
V. Structure–Function Relationships of SP-C......Page 163
References......Page 167
Biophysics and Molecular Mechanisms......Page 174
I. Introduction......Page 176
II. Membranes, Rafts, and Lung Surfactant......Page 179
III. Chain Dancing......Page 181
IV. Nanotubes Revisited......Page 183
V. Physiological Correlates......Page 185
VI. Supercool Surfactant......Page 187
VII. The Cholesterol Mystery......Page 190
VIII. Heavy Breathing: Critical Behavior Disrupted......Page 193
IX. The Future......Page 196
References......Page 197
I. Introduction......Page 204
II. Metastable Films of Pulmonary Surfactant......Page 205
III. Conclusions......Page 216
References......Page 217
8 Surfactant and Airway Liquid Flows......Page 222
II. Physiological Significance of Airway Lining Flows and Surface Tension in the Lung......Page 223
III. Interfacial Phenomena......Page 228
IV. Physiological Interfacial Flows......Page 232
V. Conclusions......Page 250
References......Page 251
I. Introduction......Page 260
II. Simulations Methodology......Page 264
III. Simulation Results......Page 266
References......Page 276
10 Analysis of Surface Topology and Chemical Composition of Microstructures Formed in Planar Surfactant Films Under Compression......Page 282
I. Introduction......Page 283
II. Topological Analysis of Domains Structures......Page 286
III. Chemical Analysis Surfactant Composition Using Imaging Time-of-Flight Secondary Ion Mass Spectrometry......Page 289
Acknowledgments......Page 303
References......Page 304
I. Introduction......Page 306
II. SP-B Surfactant Peptide Synthesis......Page 308
III. NMR Structure of SP-B Peptides......Page 314
IV. Effect of SP-B Peptides on LS Monolayer Collapse......Page 319
V. Elastic Theory of LS Monolayers......Page 324
References......Page 328
12 Structure and Function of the Molecular Film of Pulmonary Surfactant at the Air– Alveolar Interface: The Role of SP-C......Page 332
I. Basic Considerations......Page 333
II. The Role of SP-C for the Structure–Function Relationship of PS......Page 337
References......Page 345
I. Introduction......Page 348
II. SP-C Structure and Function......Page 349
IV. SP-C Transgenes Identify Regions that Specify Pulmonary Epithelial Cell Expression......Page 350
V. Altered Expression of SP-C and Familial ILD in Humans......Page 353
VI. SP-C Knockout Mice as a Model of ILD......Page 354
VII. Abnormalities in Surfactant Composition and Function with SP-C Deficiency......Page 356
Acknowledgment......Page 357
References......Page 358
14 Alternative Functions of SP-B and SP-C......Page 360
I. Introduction......Page 361
II. Clues from the Biophysical Characteristics of SP-B and SP-C......Page 362
III. Clues from the Channel Activities of Amyloid-Forming Peptides......Page 363
IV. Clues from the Channel Activities of SAPLIPs......Page 365
V. Observed Cation Channel Insertion by SP-B/C in Planar Lipid Bilayers......Page 366
VI. Observed Neutrophil Depolarization and G Protein-Mediated Calcium Mobilization by Surfactant with SP-B/C......Page 373
VII. Observed Inhibition of Neutrophil Activation by Surfactant with SP-B/C......Page 376
References......Page 381
Dysfunction and Disease......Page 388
I. Introduction......Page 390
II. Physiological Function of Pulmonary Surfactant......Page 391
III. Surfactant Composition......Page 393
V. Acute Lung Injury......Page 394
VI. Alterations of Surfactant During ALI......Page 396
VII. Mechanisms by Which Alterations of Surfactant Occur......Page 397
IX. Exogenous Surfactant Administration in ALI......Page 399
X. Conclusions and Future Directions......Page 402
References......Page 403
I. Introduction......Page 414
II. General Aspects of Airway Surfactant......Page 415
III. Surfactant Alterations in Asthma......Page 418
IV. Modulation of Immune Cells in Allergic Inflammation......Page 420
V. Therapeutic Potential and Clinical Aspects......Page 422
VI. Conclusions......Page 423
References......Page 424
I. Introduction......Page 430
II. In Vitro Studies......Page 431
III. Animal Studies......Page 438
IV. Clinical Studies......Page 440
V. Summary and Perspectives......Page 445
VI. Conclusion......Page 447
References......Page 448
18 Alteration of Alveolar Surfactant Function by Reactive Oxygen Species......Page 456
I. Introduction......Page 457
II. Reactive Oxygen Species......Page 458
III. Antioxidant Defense Mechanisms......Page 461
IV. Biophysical and Biochemical Alterations of the Surfactant System by ROS......Page 464
V. Summary......Page 472
References......Page 473
19 Novel Surfactant Therapy for Developing Countries: Current Status and Future Directions......Page 480
III. Status of Surfactant Therapy for NRDS in Developing Countries......Page 481
V. Parameters of Physiological Relevance......Page 482
VI. In Vitro Results for Herbal Oil Surfactants for NRDS......Page 483
VII. Proposed Mechanism of Action of Herbal Oil Surfactants......Page 485
VIII. Surfactant Therapy in Adult Respiratory Distress Syndrome......Page 486
IX. Surfactant Inhibition Studies In Vitro......Page 487
X. Tropical Causes of ARDS......Page 489
XII. Rheological Properties of Airway Mucus......Page 490
XIII. Interaction of Surfactants with Environmental Pollutants......Page 492
XIV. Surfactant System in Pulmonary Tuberculosis......Page 494
XV. Improved Delivery Forms of Lung Surfactant......Page 496
XVI. Issues of Toxicity of Herbal Oil Surfactants......Page 497
References......Page 498
Index......Page 502
Back cover......Page 530