دانلود کتاب Lymphocyte Activation and Differentiation: Fundamental and Clinical Aspects. Proceedings of the 18th International Leucocyte Culture Conference. La Grande Motte, France, June 19–24, 1987

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PREFACE\nCONTENTS\nINTRODUCTION\nFundamental and Clinical Aspects of Lymphocyte Activation and Differentiation\nPLENARY LECTURE\nOncogenes and Multistep Carcinogenesis\nSYMPOSIA BIOCHEMICAL AND CELLULAR ASPECTS OF LYMPHOCYTE ACTIVATION\nBiochemical and Molecular Events Controlled by Lymphoid and Myeloid Growth Factors\nPGE2 Inhibition of Human T Lymphocytes Proliferation: Regulatory Effect of PGE2 on the Intra-Cellular Signaling Pathways\nStructure-Function Relationships for the Interleukin 2 Receptor\nMonovalent Cation Fluxes as Regulators of Critical Nuclear Events in Lymphocyte Activation: Mirror Image Processes in Differentiation and Proliferation\nDiacylglycerol, Calcium, cAMP and cGMP Mediate Qualitatively Distinct Protein Kinase C Translocation Events in Normal B Lymphocytes\nPhosphorylation of Prosolin and Leucocyte Growth Regulation\nDIFFERENTIATION OF T AND B LYMPHOCYTES\nRegulation of Human B Cell Function\nThe Role of Lymphokines in the Immunoglobulin Class Switch\nMouse and Human B Cell Activating Factors\nMolecular Cloning of the Murine T11 (CD2) cDNA\nAntigen Expression and Proliferative Activity during B and T Cell Development\nMOLECULAR BIOLOGY OF LEUCOCYTES (ANTIGENS, RECEPTORS, INTERLEUKINS)\nThe Molecular Biology of the Multisubunit Interleukin-2 Receptor\nExpression and Rearrangement of T Cell Receptor Genes in Human Leukemic T Cell Lines\nThe Human T-Cell Rearranging γ Genes (TRGγ)\nImmunoglobulin Gene Expression\nStructure and Expression of Mouse Fcy Receptor II (FcyRII)\nVIRUS-INDUCED LYMPHOCYTE DYSFUNCTIONS\nThe Impact of the Presence of EBV on the Interaction of B Cell Lines with T Lymphocytes\nInduction of B Cell Activation Markers by Epstein-Barr Virus\nProduction of Interleukin-1 (IL1) by EBV-Infected Cells\nDNA-Mediated Gene Transfer of Epstein-Barr Virus Receptor onto Murine Fibroblasts\nACCESSORY CELL FUNCTIONS\nModulation of IL1 Receptor Expression by IL1, Prostaglandins and Glucocorticoids\nTumor Necrosis Factors: Modulation of Synthesis and Biological Activities\nAnalysis of the Structure and Function of Immunectin\nNatural Effector Cells of the Intestinal Epithelium: Ontogeny, Function, and Regulation\nAnalysis of Ia-Transfected Fibroblasts: Antibody and T Cell Recognition Sites Segregate with the 31 Domain of the E3 Polypeptide Chain\nWORKSHOPS WORKSHOP A. GROWTH AND DIFFERENTIATION FACTORS\nInhibition by Cyclosporin A of the IL2 Dependent Autocrine Growth in a Human Tumor T Cell Line and Fate of IL2 Receptors after Endocytosis\nInterleukin B, a B Cell-Derived Lymphokine\nInduction and Enhancement of Lymphokine Gene Expression in Human T Cell Clones Transfected with HTLV-I pX cDNA\nEvidence for a Human B Cell Activating Factor Acting on Resting B Lymphocytes\nSplicing Intermediates of the IL-2 Receptor (p55 Subunit)\nThe Role of Plasminogen Activator in Regulating T Cell Proliferation and Interferon Production\nMembrane and Soluble IL2-R Produced by Human T Cell Clones: A Comparative Study\nPhenotype and Cytokines Production by Human Myeloma Cell Lines\nB + Null Cell-Derived Prothymocyte Differentiating Activity (PTDA): Biological Properties and Physicochemical Characterization\nTDM-Activated Macrophages Produce a Cytostatic Factor Distinct from TNFα, IFNα,β, and IL-1\nCharacterization of a Factor Produced by Human Alloreactive T Cell Clones\nWORKSHOP B. MECHANISMS OF AUTOIMMUNITY\nEffector Mechanisms of Autoimmune Diseases\nT Cell Response to Myelin Basic Protein in Healthy Subjects and Multiple Sclerosis Patients\nActive T Cell Regulation of Autoimmune Responses in Autoimmune and \"Nonautoimmune\" Spleen Cell Populations\nInterleukin-2 Receptor Targeted Immunotherapy of Autoimmune Diseases: Treatment Strategies for Type I Diabetes\nProtection of Non-Obese Diabetic (NOD) Mice from Insulitis by Neonatal Injection of F₁ Spleen Cells\nWORKSHOP C. ONCOGENES AND LEUCOCYTE TRANSFORMATION\nComplex Transcriptional Regulation of Nuclear Proto Oncogenes: Existence of a Block to Elongation in C-Myc and C-Fos Genes\nDeterminants of C-Fos and C-Myc mRNAs Instability\nCloning and Functional Analysis of the Human C-fms Gene\nEffects of Proliferative (Interleukin, Colony Stimulating Factors) and Antiproliferative (Cyclic AMP, Interferon) Signals on Gene Expression in Myeloid and Lymphoid Cell Lines\nThe Progession to Tumourigenes is Following Transformation of Murine Myelomonocytic Cell by V-Myc\nHTLV-I Infection of a Human Antigen Specific Proliferating/Cytotoxic T Cell Clone Results in a Loss of Cytotoxicity but does not Affect the T Cell Receptor\nWORKSHOP D. EXPERIMENTAL MODELS OF IMMUNOMODULATION\nRoles of Monokines in the Nonspecific Host Defence Stimulated by Exogenous Agents\nEnhancement of the Immune Response Using a Synthetic B-Lymphocyte Mitogen Covalently Linked to Antigens\nEffects of in vivo Treatment of Mice with Anti-Murine T3 Antibody: Suppression of Transplantation Responses\nGamma-Interferon Protects Listeria-Susceptible BALB/c Mice from Lethal Listeriosis without Affecting the Development of Protective Immunity\nEffect of a Lipophilic Muramylitri peptide on Gamma-Interferon Induced Major Histocompatibility Antigen (MHC) and Leu-M3 Antigen Changes in Human Monocytes\nEffect of Cyclosporin A (CsA) on the Induction of Memory T Lymphocytes\nModulation by Cyclosporin A (CsA) of the Immune System of Mice Infected with Lymphocytic Choriomeningitis Virus (LCMV)\nModulation of Lymphocyte Activation in vitro by a Soluble Placental Factor\nThe Role of Interleukins and the Interleukin-2 Receptor in the Pathogenesis of Murine Cutaneous Leishmaniasis\nIn vitro Studies of Synthetic Glycolipids: A New Class of Compounds with Immunomodulating Activity\nImmunotoxicity Studies of PCB (Aroclor 1254) in the Adult Rhesus (Macaca mulatta) Monkey\nHuman Cytomegalovirus Induces Alterations in Mixed Lymphocyte Reactions\nWORKSHOP E. IMMUNODEFICIENCIES\nImmunological Aspects of AIDS and HIV Infection\nStudies Regarding the Interaction of the T4 (CD4) Molecule with the Envelope Protein gp120 of the Human Immunodeficiency Virus (HIV)\nLow Level Re-Expression of the Silent MHC Class-II Genes in the Lymphoblasts from Patients with the HLA-Class II Deficient SCID\nAdenylate Cyclase and 5\'Nucleotidase Activities of Peripheral Blood Mononuclear Cells is Psoriasis\nWORKSHOP F. NATURAL KILLER CELLS\nNatural Killer Cells\nCharacterization and Population Kinetics of Liver-Associàted Large Granular Lymphocytes (Natural Killer Cells)\nModulation of Lymphonkine Activated Killer Activity of Lymphocytes Isolated from Human Peripheral Blood and Bone Marrow by Recombinant IL4\nInhibition of Human Natural Killer Cells by Resistant Target Cells\nChanges in Gene Expression Associated with Activation or Inhibition of Natural Killer Function\nFibronectin Expression by Endogenous and Activated NK Cells\nCytolytic Potential of CD3⁺4^-8^- T Cells with Differently Organized T Cell Receptor Y Chains\nWORKSHOP G, DIFFERENTIATION AND ACTIVATION OF T LYMPHOCYTES\nCD1a Molecules Form Intermolecular Complexes with HLA Class I Molecules or Other CD1 Molecules on Normal Human Thymus Cells\nThe CD2 Pathway of Activation. Epitope Requirements, Linkage to Other Surface Molecules and Early Biochemical Events\nA T-Cell Surface Molecule Different from CD2 is Involved in Spontaneous Rosette Formation with Erythrocytes\nA Dual Function of the T4 Molecule in the Cytolytic Activity of Human T Cell Clones\nRole of Antigen-Specific T Cell Receptor and Associated Proteins in the Activation of a Cytolytic T Cell Clone Analysed by Protein Phosphorylation and by T Cell Receptor Negative Variants\nY-Chain T Cell Receptors on Denoritic Epidermal Cells\nStimulation of T Cells via LY-6C: A Phssphatidylinositol-Anchored Cell Surface Molecule which Generates Intracellular Calcium Mobilization upon Cross-Linking\nNew Subgroups in the Human T Cell Rearranging VΓ Gene Locus\nGenomic Organisation of the Constant Regions of the Human T-Cell Rearranging Gene Γ\nSecond Signals for T Cell Mitogenesis Provided by a MAbs CD45 (T200) and CD5 (T1)\nWORKSHOP H. DIFFERENTIATION AND ACTIVATION OF B LYMPHOCYTES\nImmunobiology of B Lymphocytes\nRegulation of B Lymphocyte Responsiveness by Multiple Cytokines\nInfluence of IL4 on the Induction of Immunoglobulin Secretion by BCAF-Containing Supernatant\nEarly B Cells Immortalized by Epstein-Barr Virus (EBV) - A Phenotypic Study\nThe Human B Cell Repertoire: Multispecificity as a Major Characteristic of Antibodies Secreted by Human EBV-Transformable Cord Blood B Cells\nAnalysis of Excessive B Cell Growth in Lymph Nodes of L. major Infected Mice: The Effect of L. major Specific T-Cell Clones\nAntibody Response in vitro of Human Peripheral Blood Lymphocytes: Application of a Limiting Dilution Method\nFrequency Analysis of Functional Immunoglobulin C_E Gene Expression in LPS-Reactive Murine B Cells\nChanges in Gene Expression in Differentiating B Lymphocytes\nRegulation of Lipopolysaccharide (LPS)-Induced B Cell Differentiation by Ly-5 and Uyb-2 Molecules\nWORKSHOP I. LIPIDIC MEDIATORS OF THE IMMUNE RESPONSE\nPhospholipid-Derived Mediators and the Immune Response\nAnti-Oxidants and IL2 Synthesis\nRole of Lipoxygenase Pathway Products in IL2 Synthesis\nPlatelet Activating Factor (PAF) Induces Human Suppressor Cell Activity\nPAF-Acether Induces an Enhanced Release of Interleukin-1 (IL-1) from Human Monocytes\nDown-Regulation of CD2 and CD3 Antigen Expression by PAF-Acether\nWORKSHOP J. NEURAL MODULATION OF IMMUNITY\nNeuroendocrine Modulation of Immunity\nCyclic AMP Response to Dopamine in the Human Monocyte-Like Cell Line U-937\nß-Endorphin Inhibits Thy-1 Antigen Expression on Murine Thymocytes and Antagonizes Thymosin Fraction V Action\nWORKSHOP K. BIOCHEMISTRY OF LEUCOCYTE STIMULATION AND EFFECTOR MECHANISMS\nGenes Preferentially Expressed in Cytolytic T Cells\nSignal Transduction in Lymphocyte Activation\nIL-2 Mediated Induction of Lytic Granules, Perforin, and BLT-Esterase in Potent, Granule-Free Cytolytic T Lymphocytes Indicates an Alternative Function of Lytic Granules\nExtracel1ular ATP Initiates the Proliferative Response of PMA-Activated Medullary Thymocytes by Increasing their Cytosolic Free Calcium Concentration\nEvidence for a Kinase Cascade Stimulated by Interleukin 2 in Cytotoxic T Cell Clones\nThe Regulation of Cytoskeletal Protein Gene Expression in Lymphocytes\nProtein Phosphorylation During T Cell Activation\nClues to Mechanisms of Activation for Killing from the Observations of Changes in Intracellular (Ca⁺⁺) in Individual Cytolytic T Cells and Targets\nInduction of Activation Signals in Human T Lymphocytes\nBoth Lyt2⁺ and L3T4⁺ Cell Subsets Secrete the Serine Esterase Granzyme A in Response to a Specific Antigenic Stimulus\nWORKSHOP L. ACCESSORY CELLS-LYMPHOCYTE INTERACTIONS\nAccessory Cells-Lymphocyte Interactions\nA Role for HLA-Class I Molecules from Accessory Cells in T-Cell Activation\nAdhesion Molecules of Monocytes\nCellular and Molecular Basis of Self-Induced Proliferation of T Lymphocytes (SIPofT)\nHuman T Cell Activation: Participation of T Cell Differentiation Antigen Cluster 2 (CD2) in the Generation and/or Transduction of Accessory Cell Signals\nWORKSHOP PI. IDIOTYPIC REGULATION\nThe Influence of Vk Gene Polymorphism on the Induction of Silent Idiotypes in the Arsonate System\nAllogeneic Manipulation of the \"GAT\" Idiotypic Cascade does not Influence the VH Gene Usage\nSpecific Suppression of the Primary Antibody Response with Immune Complexes Formed in Antibody Excess Depends on the Idiotype and the Isotype of the Antibody Forming the Complex\nThe HLA-Restricted Presentation of Idiotype to Human Anti-Idiotypic T Cell Clones does not Require Processing by Antigen Presenting Cells\nIdiotypic Predominance Alteration in Anti-Arsonate Response by Priming with Anti-Idiotypic Antibodies\nAnti-Idiotype Induction of Humoral Immunity in Cattle\nAnti MHC-Receptor Cytotoxic T Lymphocytes: Their Role in the Specific Resistance to Graft-Versus-Host Reaction\nAltered Anti-Idiotype Response to a(1-3)Dextran-Associated Idiotypes in Mice Bearing an X-Linked Immune Defect\nWORKSHOP N. COMPLEMENT RECEPTORS\nHuman CD3 Complement Receptors\nInfluence of Antigen-Bound Complement Components C3b and C4b in Activation of Human T-Cell Clones\nHuman C3 and C3dg Stimulate Proliferation of a Pre-B Lymphoblastoid Cell Line via CR2 Complement Receptor\nActivation of B Lymphocytes by Zymosan-Bound C3 Fragments\nContribution of C3 Fragments to Lymphocyte Mediated Lysis of CR2 Carrying Cells\n\"In vivo\" and \"in vitro\" Modulation of CR1 (C3b Receptor) Expression by its Ligand C3b\nWORKSHOP O. MAJOR HISTOCOMPATIBILITY COMPLEX\nMHC in Leucocyte Biology\nHLA Class I α1, α2, and ß2-Microglobulin Domain Interactions\nDiversity and Function of Human Class II MHC Antigens\nDRα-DQß Mismatched Isotype Pairing Occurs in EBV Transformed B Cell Lines\nDistinct Epitopes for K^d-Restricted Cytolytic T Cells Specific for HLA-CW3 or HLA-A24 Map to the same Region of HLA\nResistance or Susceptibility of Human Target Cells to NK Lysis: Correlation with the Surface Expression of HLA Class I Molecules and Induction of Susceptibility by Monoclonal Anti Class I Antibodies\nWORKSHOP P (SANOFI). CLINICAL APPLICATIONS OF ANTILEUCOCYTE MONOCLONAL ANTIBODIES\nAnti-Leucocyte Monoclonal Antibodies: From Laboratory Reagents to Therapeutic Agents\nTreatment of Donor Bone Marrow with FabT101 Ricin A-Chain Immunotoxin for the Prevention of Graft-versus-Host Disease after Allogeneic Bone Marrow Transplantation\nMonoclonal Antibodies for Bone Marrow Purging before Transplantation: A Brief Review\nComparative Efficiency of an Immunomagnetic Purging Procedure and a Rabbit Complement Lysis to Eliminate BL Cells from the Bone Marrow\nIn vivo Antigenic Modulation of CD5⁺ Cells in Renal Transplanted Patients Receiving Anti-CD5 Antibody Infusions\nIn vivo Therapy by CD8 Monoclonal Antibody for Delays to Hematological Recovery after Autologous Bone Marrow Transplantation\nAutologous Bone Marrow Transplantation for Acute Lymphoblastic Leukemia in Remission. In vitro Purging of Inoculum with Monoclonal Antibodies and Complement\nImmunosuppression by Murine Monoclonal Antibodies: The Rhesus Monkey Used for Preclinical Testing\nTherapeutic Applications of Monoclonal Antibodies for Lymphoma and Leukemia\nBMA 031 - The TCR Specific Monoclonal Antibody for Clinical Applications\nImmunoassays for the Monitoring of Kidney Graft\'s Transplanted Patients under 33B3.1 MOAB Therapy\nProspective Randomized Studies of T Cell Depletion in HLA Matched Bone Marrow Transplantation (BMT) for Leukemia: 2 Studies of the GEGMO in 92 Patients\nA Monoclonal Anti Interleukin 2 Receptor Prevents Human Kidney Graft Rejection\nClinical Pharmacology of 0KT3\nIntroduction to the Clinical Use of Monoclonal Antibodies as Immunosuppressive Agents\nGeneral Considerations on the Quality Control of Monoclonal Antibodies before Therapeutic Use in Man\nImmunotoxins with Therapeutic Use in Man\nAUTHOR INDEX\nSUBJECT INDEX