دانلود کتاب Mass Spectrometry for Drug Discovery and Drug Development

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With coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book's fifteen chapters have been written by leading pharmaceutical and analytical scientists. Their contributions are based on a thorough review of the current literature as well as their own experience developing new mass spectrometry techniques to improve the ability to discover and develop new and effective therapeutics.

Mass Spectrometry for Drug Discovery and Drug Development begins with an overview of the types of mass spectrometers that facilitate drug discovery and development. Next it covers:

• HPLC?high-resolution mass spectrometry for quantitative assays
• Mass spectrometry for siRNA
• Quantitative analysis of peptides
• Mass spectrometry analysis of biological drugs
• Applications that support medicinal chemistry investigations
• Mass spectrometry imaging and profiling

Throughout the book, detailed examples underscore the growing role of mass spectrometry throughout the drug discovery and development process. In addition, images of mass spectra are provided to explain how results are interpreted. Extensive references at the end of each chapter guide readers to the primary literature in the field.

Mass Spectrometry for Drug Discovery and Drug Development is recommended for readers in pharmaceutics, including medicinal chemists, analytical chemists, and drug metabolism scientists. All readers will discover how mass spectrometry can streamline and advance new drug discovery and development efforts.

Content:
Chapter 1 Overview of the Various Types of Mass Spectrometers that are Used in Drug Discovery and Drug Development (pages 1–35): Gerard Hopfgartner
Chapter 2 Utility of High?Resolution Mass Spectrometry for New Drug Discovery Applications (pages 37–54): William Bart Emary and Nanyan Rena Zhang
Chapter 3 Quantitative Mass Spectrometry Considerations in a Regulated Environment (pages 55–95): Mohammed Jemal and Yuan?qing Xia
Chapter 4 Mass Spectrometry for Quantitative In Vitro ADME Assays (pages 97–113): Jun Zhang and Wilson Z. Shou
Chapter 5 Metabolite Identification Using Mass Spectrometry in Drug Development (pages 115–147): Natalia Penner, Joanna Zgoda?Pols and Chandra Prakash
Chapter 6 MS Analysis of Biological Drugs, Proteins, and Peptides (pages 149–190): Yi Du, John Mehl and Pavlo Pristatsky
Chapter 7 Characterization of Impurities and Degradation Products in Small Molecule Pharmaceuticals and Biologics (pages 191–220): Hui Wei, Guodong Chen and Adrienne A. Tymiak
Chapter 8 Liquid Extraction Surface Analysis (LESA): A New Mass Spectrometry?Based Technique for Ambient Surface Profiling (pages 221–238): Daniel Eikel and Jack D. Henion
Chapter 9 MS Applications in Support of Medicinal Chemistry Sciences (pages 239–275): Maarten Honing, Benno Ingelse and Birendra N. Pramanik
Chapter 10 Imaging Mass Spectrometry of Proteins and Peptides (pages 277–302): Michelle L. Reyzer and Richard M. Caprioli
Chapter 11 Imaging Mass Spectrometry for Drugs and Metabolites (pages 303–337): Stacey R. Oppenheimer
Chapter 12 Screening Reactive Metabolites: Role of Liquid Chromatography–High?Resolution Mass Spectrometry in Combination with “Intelligent” Data Mining Tools (pages 339–355): Shuguang Ma and Swapan K. Chowdhury
Chapter 13 Mass Spectrometry of siRNA (pages 357–385): Mark T. Cancilla and Michael Flanagan
Chapter 14 Mass Spectrometry for Metabolomics (pages 387–401): Petia Shipkova and Michael D. Reily
Chapter 15 Quantitative Analysis of Peptides with Mass Spectrometry: Selected Reaction Monitoring or High?Resolution Full Scan? (pages 403–425): Lieve Dillen and Filip Cuyckens