دانلود کتاب Molecular Aspects of Myeloid Stem Cell Development

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Front Matter....Pages I-XIV
Front Matter....Pages 1-1
Molecular Control of Development in Normal and Leukemic Myeloid Cells by Cytokines, Tumor Suppressor and Oncogenes....Pages 3-5
Retinoic Acid Receptors in Hematopoiesis....Pages 7-15
Role of c-myc in Myeloid Differentiation, Growth Arrest and Apoptosis....Pages 17-27
Self Renewal and Differentiation in Primary Avian Hematopoietic Cells: An Alternative to Mammalian in Vitro Models?....Pages 29-39
Front Matter....Pages 41-41
The Effect of C-raf Antisense Oligonucleotides on Growth Factor-Induced Proliferation of Hematopoietic Cells....Pages 43-53
Protein Kinase C-δ, an Important Signaling Molecule in the Platelet-Derived Growth Factor β Receptor Pathway....Pages 55-65
Novel Adapter Proteins that Link the Human GM-CSF Receptor to the Phosphatidylino-sitol 3-Kinase and Shc/Grb2/ras Signaling Pathways....Pages 67-75
Front Matter....Pages 77-77
Functional Analysis of the c-myb Proto-Oncogene....Pages 79-87
Structure and Function of the Proteins Encoded by the myb Gene Family....Pages 89-98
The c-Myb Negative Regulatory Domain....Pages 99-109
Front Matter....Pages 111-111
Terminal Myeloid Gene Expression and Differentiation Requires the Transcription Factor PU.1....Pages 113-119
A Role for STAT Family Transcription Factors in Myeloid Differentiation....Pages 121-128
Regulation of C/EBPβ/NF-M Activity by Kinase Oncogenes....Pages 129-136
Function of PU.1 (Spi-1), C/EBP, and AML1 in Early Myelopoiesis: Regulation of Multiple Myeloid CSF Receptor Promoters....Pages 137-147
Regulation of Immature Myeloid Cell Differentiation by PEBP2/CBF, MYB, C/EBP and ETS Family Members....Pages 149-157
Hematopoietic Transcriptional Regulation by the Myeloid Zinc Finger Gene, MZF-1....Pages 159-164
Coordinate Regulation of Neutrophil Secondary Granule Protein Gene Expression....Pages 165-171
Interleukin-5 Receptor α Subunit Gene Regulation in Human Eosinophil Development: Identification of a Unique Cis-Element that acts lie an Enhacer in Regulating Activity of the IL-5Rα Promoter....Pages 173-187
Front Matter....Pages 189-189
Retroviral Insertional Mutagenesis in Murine Promonocytic Leukemias: c-myb and Mm /1....Pages 191-199
Molecular Analysis and Characterization of Two Myeloid Leukemia Inducing Murine Retroviruses....Pages 201-210
Front Matter....Pages 189-189
Molecular Analysis of E vi 1, a Zinc Finger Oncogene Involved in Myeloid Leukemia....Pages 211-222
Activation of Stat-related DNA-binding Factors by Erythropoietin and the Spleen Focus-Forming Virus....Pages 223-231
The Neurofibromatosis Type 1 (NF1) Tumor Suppressor Gene and Myeloid Leukemia....Pages 233-239
Front Matter....Pages 241-241
Rearrangement of the AML1/CBFA2 Gene in Myeloid Leukemia with the 3;21 Translocation:Expression of Co-Existing Multiple Chimeric Genes with Similar Functions as Transcriptional Repressors, but with Opposite Tumorigenic Properties....Pages 243-252
Transcriptional Regulation by the t(8;21 )Fusion Protein, AML-1/ETO....Pages 253-258
The Mixed Lineage Leukemia (MLL) Protein Involved in 11 q23 Translocations Contains a Domain that Binds Cruciform DNA and Scaffold Attachment Region (SAR) DNA....Pages 259-268
Pathogenetic Role of the PML/RARα Fusion Protein in Acute Promyelocytic Leukemia....Pages 269-278
Involvement of the TEL Gene in Hematologic Malignancy by Diverse Molecular Genetic Mechanisms....Pages 279-288
Transforming Properties of the Leukemic Inv(16) Fusion Gene CBFB-MYH11 ....Pages 289-298
Back Matter....Pages 299-300