دانلود کتاب Mucopolysaccharides - Glycosaminoglycans - of body fluids in health and disease

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Preface\n1. Chemistry and Metabolism of Glycosaminoglycans and Proteoglycans\n1.1 Nature and classification\n1.2 Modern nomenclature\n1.3 Development of terminology\n1.4 Other related terms in literature\n1.5 Occurrence\n1.6 Chemical structures\n1.7 Organization as proteoglycans and aggregates\n1.8 Role of silicon in molecular organization of glycosaminoglycans\n1.9 Interactions with basic compounds and cations\n1.10 Interaction with other macromolecules\n1.11 Biosynthesis of glycosaminoglycans and proteoglycans\n1.12 Degradation of proteoglycans and glycosaminoglycans\n1.13 Effects of vitamins, hormones and minerals, etc\n1.14 Bibliography\n2. General Methods for Isolation, Fractionation and Analysis\n2.1 Introduction\n2.2 Isolation procedures\n2.3 Fractionation of GAG mixtures\n2.4 Molecular weight determination\n2.5 Fractionation by preparative electrophoresis\n2.6 Characterization by microscopic, optical and spectrometric methods\n2.7 Analysis without hydrolysis\n2.8 Analysis of components in hydrolysates\n2.9 Microfractionation and microanalysis of glycosaminoglycans in mixtures\n2.10 Keratan sulfate determination\n2.11 Hyaluronic acid determination\n2.12 Determination of dermatan and chondroitin sulfates\n2.13 Bibliography\n3. Biological Functions and Therapeutic Uses of Glycosaminoglycans\n3.1 Introduction\n3.2 Control of collagen formation and organization\n3.3 Control of water in extracellular tissues\n3.4 Role in urine concentrating process of kidney\n3.5 Role in immunity, infection and inflammation\n3.6 Role in wound healing\n3.7 Role in eye\n3.8 Role in central nervous system\n3.9 Role in biological lubrication and biomechanics\n3.10 Role in stone formation (lithiasis)\n3.11 Role in hair growth\n3.12 Role as ion-exchangers\n3.13 Role in morphogenesis\n3.14 Role in cell proliferation\n3.15 Role in calcification\n3.16 Therapeutic uses of glycosaminoglycans\n3.17 Bibliography\n4. Gastrointestinal Tract Fluids\n4.1 Introduction\n4.2 Methods of analysis and fractionation\n4.3 Gastric juice\n4.4 Intestinal fluids\n4.5 Aging-related changes in gastrointestinal fluids\n4.6 Gastrointestinal changes in cystic fibrosis\n4.7 Bibliography\n5. Glycosaminoglycans in Fluids and Fluid-Associated Tissues of the Oral Cavity\n5.1 Introduction\n5.2 Salivary apparatus and salivary secretion\n5.3 Mucosubstances in saliva and salivary glands\n5.4 Glycosaminoglycans of gingival fluid and gingiva\n5.5 Glycosaminoglycans in oral cyst fluid\n5.6 Relationship between dental plaque, periodontal disease and salivary flow\n5.7 Age-related changes in polysaccharides of salivary glands and oral mucosa\n5.8 Bibliography\n6. Mucopolysaccharides in Fluids and Fluid-Associated Membranes of Respiratory Tract\n6.1 Introduction\n6.2 Mucus production and mucociliary function\n6.3 Mucopolysaccharides in nasal secretion\n6.4 Factors affecting nature and quantity of nasal secretion\n6.5 Nasal secretion in cystic fibrosis\n6.6 Glycosaminoglycans of nasal and paranasal mucous membranes\n6.7 Acidic glycosaminoglycans in paranasal sinus mucosa\n6.8 Mucopolysaccharides in nasal and paranasal carcinoma\n6.9 Mucopolysaccharides of sputum\n6.10 Mucopolysaccharides in bronchial secretion\n6.11 Factors affecting bronchial secretion\n6.12 Bibliography\n7. Ocular Fluids\n7.1 Introduction\n7.2 Lacrimal secretion or tears\n7.3 Aqueous humor\n7.4 Vitreous humor\n7.5 Subretinal fluid\n7.6 Bibliography\n8. Bile\n8.1 Physiological aspects\n8.2 Source and functions of bile mucins\n8.3 Mucosubstances in bile\n8.4 Hexuronic acid conjugates in bile\n8.5 Changes in physiological and pathological states\n8.6 Bibliography\n9. Fluids Associated with Embryonic Membranes\n9.1 Introduction\n9.2 Wharton\'s jelly of umbilical cord\n9.3 Glycosaminoglycans in Allantoic fluid\n9.4 Glycosaminoglycans in eggs\n9.5 Glycosaminoglycans of cardiac jelly\n9.6 Bibliography\n10. Glycosaminoglycans of Fluids and Fluid-Associated Tissues of Ear\n10.1 General consideration\n10.2 Secretion in external ear: Cerumen\n10.3 Pathological middle ear fluid\n10.4 Inner ear fluids: Perilymph and endolymph\n10.5 Source of inner ear fluids\n10.6 Glycosaminoglycans in delicate membranes of inner ear\n10.7 Effects of hormones and vitamins in inner ear\n10.8 Experimental studies in myxedema (hypothyroidism)\n10.9 Pathological glycosaminoglycan changes in the inner ear\n10.10 Role of glycosaminoglycans in inner ear function\n10.11 Addendum\n10.12 Bibliography\n11. Amniotic Fluid (Liquor amnii)\n11.1 Introduction\n11.2 Origin, volume and fate of amniotic fluid\n11.3 Relationship of amniotic fluid to urine\n11.4 Methods of analysis and fractionation\n11.5 Normal glycosaminoglycan composition\n11.6 Source of glycosaminoglycans in amniotic fluid\n11.7 Glycosaminoglycans variation with gestational age\n11.8 Pathological changes in amniotic fluid glycosaminoglycans\n11.9 Amniocentesis and intrauterine diagnosis of mucopolysaccharidoses: Problems and prospects\n11.10 Bibliography\n12. Synovial Fluid\n12.1 Introduction\n12.2 Volume and general composition\n12.3 Glycosaminoglycan composition\n12.4 Source of Glycosaminoglycans\n12.5 Analytical and fractionation methods\n12.6 Alterations in physiological and pathological states\n12.7 Alterations in Viscosity\n12.8 Synovial membrane in rheumatoid arthritis\n12.9 Bibliography\n13. Mucopolysaccharides of Physiological and Pathological Fluid Accumulations (Effusions)\n13.1 Introduction\n13.2 Glycosaminoglycans in extracellular fluids of tumors\n13.3 Blister fluids\n13.4 Cyst fluids\n13.5 Glycosaminoglycans of edema fluids\n13.6 Edema fluid from sexual skin\n13.7 Leprous infiltrates\n13.8 Mucopolysaccharides of serous effusions\n13.9 Bibliography\n14. Fluids of the Reproductive System\n14.1 Introduction\n14.2 Semen or seminal fluid\n14.3 Female reproductive system\n14.4 Bibliography\n15. Cerebrospinal Fluid\n15.1 Introduction\n15.2 Location, origin and fate of CSF\n15.3 Glycosaminoglycans in normal CSF\n15.4 Source of CSF glycosaminoglycans\n15.5 Relationship of CSF glycosaminoglycans to age\n15.7 Lysosomal GAG hydrolyzing enzymes in CSF\n15.8 Effects of hyaluronidase injection into CSF\n15.9 Bibliography\n16. Glycosaminoglycans of Blood\n16.1 Introduction\n16.2 Source of Plasma Glycosaminoglycans\n16.3 Relationship between glycosaminoglycans in blood and urine\n16.4 Methods of analysis and fractionation\n16.5 Glycosaminoglycans of plasma and serum\n16.6 Glycosaminoglycans of formed elements\n16.7 Physiological and pathological variations in blood glycosaminoglycans\n16.8 Bibliography\n17. Glycosaminoglycans of Urine\n17.1 Introduction\n17.2 Source of urinary glycosaminoglycans\n17.3 Analysis and fractionation procedures\n17.4 Glycosaminoglycans of normal urine\n17.5 Nondialyzable, polymeric and dialyzable, low molecular weight fractions\n17.6 Relationship between plasma, urine and amniotic fluid levels\n17.7 Relationship between glycosaminoglycan and 17-hydroxycorticosteroid excretion\n17.8 Urinary glycosaminoglycans and renal lithiasis\n17.9 Effects of physiological factors\n17.10 Alterations in pathological states\n17.11 Bibliography\n18. Secretions of the Skin\n18.1 General Views\n18.2 Glycosaminoglycans in normal sweat\n18.3 Glycosaminoglycans of sweat glands in pathological states\n18.4 Variations with age and sex\n18.5 Glycosaminoglycans in sebaceous secretions\n18.6 Hormonal control of sebaceous secretion\n18.7 Bibliography\n19. Other Miscellaneous Body Fluids\n19.1 Milk\n19.2 Interstitial fluid\n19.3 Lymph\n19.4 Cartilage Fluid\n19.5 Bibliography\nSubject Index