دانلود کتاب Neurological Complications of Systemic Cancer and Antineoplastic Therapy 2e Herbert B. Newton (editor), Mark G. Malkin (editor)

فهرست مطالب :

Cover image
Title page
Table of Contents
Copyright
Dedication
Contributors
About the editors
Preface
Section I: Metastatic neurological complications
Chapter 1: Common symptoms at presentation of nervous system metastases
Abstract
1: Introduction
2: Brain metastases
3: Leptomeningeal disease
4: Spinal cord metastases
5: Epidural spinal cord metastases/epidural spinal cord compression
6: Cauda equina syndrome
7: Neoplastic and radiation plexopathy
8: Conclusion
References
Chapter 2: Neuroimaging of systemic metastatic disease
Abstract
Acknowledgment
1: Technical considerations
2: Anatomic locations
3: Intracranial complications of systemic disease
References
Chapter 3: Nonimaging evaluation of patients with nervous system metastases
Abstract
Disclosures
1: Introduction
2: Electroencephalography
3: Evoked potentials
4: Electromyography and nerve conduction studies
5: Nerve biopsy
6: Cerebrospinal fluid
7: Conclusion
References
Chapter 4: Biology and pathophysiology of central nervous system metastases
Abstract
1: Introduction
2: Molecular biology of neoplasms
3: Mechanisms of brain metastasis
4: Biological mechanisms of the metastatic cascade
5: Blood–brain barrier
6: Genetics of metastases
7: Conclusion
Disclosure
References
Chapter 5: Intracranial metastases
Abstract
1: Introduction and epidemiology
2: Pathology
3: Clinical presentation
4: Neuroimaging
5: Surgical therapy
6: Radiation therapy
7: Chemotherapy
References
Further reading
Chapter 6: Neurosurgical approaches to the treatment of intracranial metastases
Abstract
1: Background
2: Initial approach
3: Tumor resection
4: Surgical adjuncts
5: Other neurosurgical techniques
6: Management of recurrence—When to repeat resection
7: Management of CNS metastases in uncommon locations
8: Conclusion
Disclosures
References
Chapter 7: Epidural metastasis and spinal cord compression
Abstract
1: Introduction
2: Epidemiology
3: Pathophysiology
4: Clinical presentation
5: Diagnosis
6: Prognosis
7: Treatment
8: Conclusion
References
Chapter 8: Leptomeningeal metastasis
Abstract
1: Introduction
2: Prognosis
3: Anatomy
4: Pathogenesis
5: Clinical presentation
6: Diagnostic studies/staging
7: Treatment
8: Summary
References
Chapter 9: Cranial nerve involvement by metastatic cancer
Abstract
1: Introduction
2: Clinical presentation of cranial nerve involvement
3: Typical imaging findings of cranial nerve involvement
4: Cancers of special interest
5: Summary
References
Chapter 10: Cancer-related plexopathies
Abstract
1: Introduction
2: Review of plexus anatomy
3: Plexopathy
4: Diagnosis of plexopathy in patients with cancer
5: Diagnostic studies
6: Cancers of special interest
7: Supportive treatment of cancer-related plexopathy
8: Summary
References
Section II: Nonmetastatic neurological complications
Chapter 11: Cerebrovascular complications of malignancy
Abstract
1: Epidemiology of cerebrovascular disease in malignancy
2: Direct tumor effects and intracranial hemorrhage
3: Direct tumor effects and cerebral infarction
4: Coagulation disorders
5: Cancer-related infectious disease and stroke: Septic cerebral infarction
6: Infectious vasculitis
7: Complications of cancer treatment
8: Conclusion
References
Chapter 12: Metabolic and nutritional nervous system dysfunction in cancer patients
Abstract
1: Introduction
2: Metabolic and toxic encephalopathy
3: Tumor lysis syndrome
4: Cancer anorexia-cachexia syndrome
5: Nutritional myelopathy
6: Peripheral neuropathy
7: Nutritional and toxic myopathy
8: Immunotherapy side effects
9: CAR-T cell complications
References
Chapter 13: Central nervous system infections in cancer patients
Abstract
1: Introduction
2: Approach to cancer patients with suspected CNS infection
3: High-risk patient groups
4: Management of common CNS infections
5: Vaccine-preventable infections: The COVID-19 pandemic and cancer patients
6: Conclusions
References
Chapter 14: Diagnosis and treatment of paraneoplastic neurological disorders
Abstract
1: Introduction
2: Pathogenesis
3: Clinical diagnosis
4: Antineuronal antibodies
5: Treatment
6: Underlying malignancy
7: Paraneoplastic disorders and immune checkpoint inhibitors
8: Paraneoplastic neurological disorders
9: Conclusion
References
Section III: Neurological complications of specific neoplasms
Chapter 15: Neurological complications of lung cancer
Abstract
1: Introduction
2: Direct complications of lung cancer
3: Indirect complications of lung cancer
References
Chapter 16: Neurological complications of breast cancer
Abstract
1: Introduction
2: Metastatic complications
3: Nonmetastatic complications
4: Regional approach to the diagnosis of neurological symptoms
5: Conclusion
References
Chapter 17: Neurological complications of melanoma
Abstract
1: Introduction
2: Neurological complications of malignant melanoma
3: Neurological complications of noncutaneous melanomas
References
Chapter 18: Neurological complications of lymphoma
Abstract
1: Introduction
2: Intracranial metastases
3: Spinal cord processes
4: Peripheral nervous system disease
5: Paraneoplastic neurological syndromes
References
Chapter 19: Neurologic complications of the leukemias
Abstract
1: Introduction
2: Diagnostic considerations
3: The acute leukemias
4: The chronic leukemias
5: Conclusion
References
Chapter 20: Neurological complications of systemic cancer of the head and neck
Abstract
1: Introduction
2: Local and locoregional complications
3: Distant metastases
4: Leptomeningeal carcinomatosis
5: Medical therapy
6: Syncope in patients with head and neck cancer
References
Further reading
Chapter 21: Neurological complications of gynecological cancers
Abstract
1: Introduction
2: Local/regional spread of gynecological cancers to the lumbosacral plexus
3: Distant CNS metastases from gynecological cancers
4: Paraneoplastic syndromes due to gynecological cancers
5: Neurological complications associated with treatment of gynecological cancers
6: Conclusion
References
Chapter 22: Neurological complications of GI cancers
Abstract
Permissions summary
1: Overview of gastrointestinal cancers
2: Neurological complications of GI cancers
3: Common systemic treatment regimens for GI cancers and their neurological complications
References
Chapter 23: Neurologic complications associated with genitourinary cancer
Abstract
1: Introduction
2: Prostate cancer
3: Uterus
4: Ovarian cancer
5: Renal carcinoma
6: Germ cell testicular cancer
7: Bladder carcinoma
8: Conclusion
References
Chapter 24: Sarcoma and the nervous system
Abstract
1: Introduction
2: Primary CNS sarcomas
3: Primary sarcomas of the peripheral nervous system
4: Extra-CNS sarcoma affecting the nervous system
5: CNS metastases from extra-CNS sarcoma
6: Neurologic toxicities from sarcoma treatments
7: Conclusions
References
Chapter 25: Neurological complications of multiple myeloma
Abstract
1: Introduction
2: Central nervous system complications
3: Peripheral nervous system complications
4: Conclusion
References
Chapter 26: Neurologic complications in the treatment of childhood malignancies
Abstract
1: Introduction
2: Part I: Acute complications of cancer treatment
3: Part II: Late effects of cancer treatment
4: Conclusion
References
Section IV: Neurological complications of antineoplastic therapy
Chapter 27: Neurological complications of radiation therapy
Abstract
1: Introduction
2: Pathophysiology of neurological complications from radiation
3: Radiation-induced brain toxicity
4: Radiation-induced complications of spinal cord
5: Radiation-induced nerve injury
6: Endocrinopathy after radiation therapy
7: Cerebrovascular complications after radiation treatment
8: Radiation-induced secondary malignancy
9: Conclusion
References
Chapter 28: Neurological complications of systemic cancer and antineoplastic therapy
Abstract
1: Introduction
2: Mechanisms of neurotoxicity
3: Neurotixicity of specific agents
4: Targeted therapies
5: Biological agents
6: Chemotherapy-induced cognitive impairment
7: Conclusion
References
Chapter 29: Neurological complications of hematopoietic stem cell transplantation
Abstract
1: Introduction
2: Neurologic complications associated with conditioning regimens
3: Toxic-metabolic encephalopathy
4: Cerebrovascular complications
5: CNS infections
6: Neurologic complications associated with chronic graft versus host disease (GVHD)
7: Neurologic complications associated with immunosuppressive therapy
8: Neurocognitive dysfunction
9: Secondary malignancies
10: Conclusion
References
Chapter 30: Chemotherapy-induced peripheral neuropathy
Abstract
1: Introduction
2: Pathophysiology of CIPN
3: Clinical presentation and diagnostic evaluation of CIPN
4: Clinical management of CIPN
References
Chapter 31: Neurological complications of immunotherapy and monoclonal antibody therapy
Abstract
1: Introduction
2: Bevacizumab
3: Cetuximab and other anti-EGFR mAbs
4: Trastuzumab
5: Rituximab and other anti-CD20 mAbs
6: Dinutuximab
7: Brentuximab vedotin
8: Polatuzumab vedotin
9: Enfortumab vedotin
10: Trastuzumab emtansine
11: Blinatumomab
12: Interleukin-2 (IL2)
13: Interferon alpha
References
Chapter 32: Neurologic complications of immune modulatory therapy
Abstract
1: Introduction
2: Epidemiology
3: Headache
4: Malignant cerebral edema
5: Peripheral nervous system
6: Central nervous system
7: CAR T cell-mediated neurotoxicity (immune effector cell-associated neurotoxicity syndrome)
8: Conclusion: Diverse presentation, kinetics, importance of multidisciplinary and early treatment, consideration of re-challenge
References
Chapter 33: Neurological complications of steroids and of supportive care
Abstract
Acknowledgment
1: Introduction
2: Corticosteroids
3: Seizures
4: Vascular complications
5: Analgesics
6: Antiemetics
7: Depression
8: Summary
References
Section V: Psychiatric, pain, psychosocial, and supportive care issues
Chapter 34: Psychiatric aspects of care in the cancer patient
Abstract
1: Introduction
2: Historical background
3: Common psychological responses to cancer
4: Epidemiology of psychiatric disorders in cancer patients
5: General principles of psychiatric assessment and treatment in patients with cancer
6: Delirium
7: Adjustment disorders
8: Anxiety disorders
9: Trauma and stressor-related disorders
10: Depressive disorders
11: Suicide assessment and management in cancer patients
12: Psychiatric considerations in cancer-related fatigue
13: Cancer survivors
14: Families issues and bereavement
15: Psychological issues for staff
References
Chapter 35: Chronic cancer pain syndromes and their treatment
Abstract
1: Bone pain
2: Pain syndromes of the viscera and miscellaneous tumor-related syndromes
3: Headache and facial pain
4: Neuropathic pain involving the peripheral nervous system
5: Paraneoplastic nociceptive pain syndromes
6: Chronic pain syndromes associated with cancer therapy
7: Clinical evaluation of the patients with difficult pain
References
Further reading
Chapter 36: Psychosocial issues in cancer patients with neurological complications
Abstract
1: Introduction
2: Neurocognitive concerns
3: Psychological concerns
4: Behavioral concerns
5: Social concerns
6: Disparity concerns
7: End-of-life concerns
8: Conclusion
References
Chapter 37: Supportive care
Abstract
1: Introduction
2: Novel antiangiogenic agents
3: Conclusion
References
Index
Copyright
Title Page
Dedication
Contents
Chapter 1: ‘I’m thinking’ – Oh, but are you?
Chapter 2: Renegade perception
Chapter 3: The Pushbacker sting
Chapter 4: ‘Covid’: The calculated catastrophe
Chapter 5: There is no ‘virus’
Chapter 6: Sequence of deceit
Chapter 7: War on your mind
Chapter 8: ‘Reframing’ insanity
Chapter 9: We must have it? So what is it?
Chapter 10: Human 2.0
Chapter 11: Who controls the Cult?
Chapter 12: Escaping Wetiko
Postscript
Appendix: Cowan-Kaufman-Morell Statement on Virus Isolation
Bibliography
Index
Copyright
Title Page
Dedication
Contents
Chapter 1: ‘I’m thinking’ – Oh, but are you?
Chapter 2: Renegade perception
Chapter 3: The Pushbacker sting
Chapter 4: ‘Covid’: The calculated catastrophe
Chapter 5: There is no ‘virus’
Chapter 6: Sequence of deceit
Chapter 7: War on your mind
Chapter 8: ‘Reframing’ insanity
Chapter 9: We must have it? So what is it?
Chapter 10: Human 2.0
Chapter 11: Who controls the Cult?
Chapter 12: Escaping Wetiko
Postscript
Appendix: Cowan-Kaufman-Morell Statement on Virus Isolation
Bibliography
Index
Copyright
Title Page
Dedication
Contents
Chapter 1: ‘I’m thinking’ – Oh, but are you?
Chapter 2: Renegade perception
Chapter 3: The Pushbacker sting
Chapter 4: ‘Covid’: The calculated catastrophe
Chapter 5: There is no ‘virus’
Chapter 6: Sequence of deceit
Chapter 7: War on your mind
Chapter 8: ‘Reframing’ insanity
Chapter 9: We must have it? So what is it?
Chapter 10: Human 2.0
Chapter 11: Who controls the Cult?
Chapter 12: Escaping Wetiko
Postscript
Appendix: Cowan-Kaufman-Morell Statement on Virus Isolation
Bibliography
Index
Cover image
Title page
Table of Contents
Copyright
Dedication
Contributors
About the editors
Preface
Section I: Metastatic neurological complications
Chapter 1: Common symptoms at presentation of nervous system metastases
Abstract
1: Introduction
2: Brain metastases
3: Leptomeningeal disease
4: Spinal cord metastases
5: Epidural spinal cord metastases/epidural spinal cord compression
6: Cauda equina syndrome
7: Neoplastic and radiation plexopathy
8: Conclusion
References
Chapter 2: Neuroimaging of systemic metastatic disease
Abstract
Acknowledgment
1: Technical considerations
2: Anatomic locations
3: Intracranial complications of systemic disease
References
Chapter 3: Nonimaging evaluation of patients with nervous system metastases
Abstract
Disclosures
1: Introduction
2: Electroencephalography
3: Evoked potentials
4: Electromyography and nerve conduction studies
5: Nerve biopsy
6: Cerebrospinal fluid
7: Conclusion
References
Chapter 4: Biology and pathophysiology of central nervous system metastases
Abstract
1: Introduction
2: Molecular biology of neoplasms
3: Mechanisms of brain metastasis
4: Biological mechanisms of the metastatic cascade
5: Blood–brain barrier
6: Genetics of metastases
7: Conclusion
Disclosure
References
Chapter 5: Intracranial metastases
Abstract
1: Introduction and epidemiology
2: Pathology
3: Clinical presentation
4: Neuroimaging
5: Surgical therapy
6: Radiation therapy
7: Chemotherapy
References
Further reading
Chapter 6: Neurosurgical approaches to the treatment of intracranial metastases
Abstract
1: Background
2: Initial approach
3: Tumor resection
4: Surgical adjuncts
5: Other neurosurgical techniques
6: Management of recurrence—When to repeat resection
7: Management of CNS metastases in uncommon locations
8: Conclusion
Disclosures
References
Chapter 7: Epidural metastasis and spinal cord compression
Abstract
1: Introduction
2: Epidemiology
3: Pathophysiology
4: Clinical presentation
5: Diagnosis
6: Prognosis
7: Treatment
8: Conclusion
References
Chapter 8: Leptomeningeal metastasis
Abstract
1: Introduction
2: Prognosis
3: Anatomy
4: Pathogenesis
5: Clinical presentation
6: Diagnostic studies/staging
7: Treatment
8: Summary
References
Chapter 9: Cranial nerve involvement by metastatic cancer
Abstract
1: Introduction
2: Clinical presentation of cranial nerve involvement
3: Typical imaging findings of cranial nerve involvement
4: Cancers of special interest
5: Summary
References
Chapter 10: Cancer-related plexopathies
Abstract
1: Introduction
2: Review of plexus anatomy
3: Plexopathy
4: Diagnosis of plexopathy in patients with cancer
5: Diagnostic studies
6: Cancers of special interest
7: Supportive treatment of cancer-related plexopathy
8: Summary
References
Section II: Nonmetastatic neurological complications
Chapter 11: Cerebrovascular complications of malignancy
Abstract
1: Epidemiology of cerebrovascular disease in malignancy
2: Direct tumor effects and intracranial hemorrhage
3: Direct tumor effects and cerebral infarction
4: Coagulation disorders
5: Cancer-related infectious disease and stroke: Septic cerebral infarction
6: Infectious vasculitis
7: Complications of cancer treatment
8: Conclusion
References
Chapter 12: Metabolic and nutritional nervous system dysfunction in cancer patients
Abstract
1: Introduction
2: Metabolic and toxic encephalopathy
3: Tumor lysis syndrome
4: Cancer anorexia-cachexia syndrome
5: Nutritional myelopathy
6: Peripheral neuropathy
7: Nutritional and toxic myopathy
8: Immunotherapy side effects
9: CAR-T cell complications
References
Chapter 13: Central nervous system infections in cancer patients
Abstract
1: Introduction
2: Approach to cancer patients with suspected CNS infection
3: High-risk patient groups
4: Management of common CNS infections
5: Vaccine-preventable infections: The COVID-19 pandemic and cancer patients
6: Conclusions
References
Chapter 14: Diagnosis and treatment of paraneoplastic neurological disorders
Abstract
1: Introduction
2: Pathogenesis
3: Clinical diagnosis
4: Antineuronal antibodies
5: Treatment
6: Underlying malignancy
7: Paraneoplastic disorders and immune checkpoint inhibitors
8: Paraneoplastic neurological disorders
9: Conclusion
References
Section III: Neurological complications of specific neoplasms
Chapter 15: Neurological complications of lung cancer
Abstract
1: Introduction
2: Direct complications of lung cancer
3: Indirect complications of lung cancer
References
Chapter 16: Neurological complications of breast cancer
Abstract
1: Introduction
2: Metastatic complications
3: Nonmetastatic complications
4: Regional approach to the diagnosis of neurological symptoms
5: Conclusion
References
Chapter 17: Neurological complications of melanoma
Abstract
1: Introduction
2: Neurological complications of malignant melanoma
3: Neurological complications of noncutaneous melanomas
References
Chapter 18: Neurological complications of lymphoma
Abstract
1: Introduction
2: Intracranial metastases
3: Spinal cord processes
4: Peripheral nervous system disease
5: Paraneoplastic neurological syndromes
References
Chapter 19: Neurologic complications of the leukemias
Abstract
1: Introduction
2: Diagnostic considerations
3: The acute leukemias
4: The chronic leukemias
5: Conclusion
References
Chapter 20: Neurological complications of systemic cancer of the head and neck
Abstract
1: Introduction
2: Local and locoregional complications
3: Distant metastases
4: Leptomeningeal carcinomatosis
5: Medical therapy
6: Syncope in patients with head and neck cancer
References
Further reading
Chapter 21: Neurological complications of gynecological cancers
Abstract
1: Introduction
2: Local/regional spread of gynecological cancers to the lumbosacral plexus
3: Distant CNS metastases from gynecological cancers
4: Paraneoplastic syndromes due to gynecological cancers
5: Neurological complications associated with treatment of gynecological cancers
6: Conclusion
References
Chapter 22: Neurological complications of GI cancers
Abstract
Permissions summary
1: Overview of gastrointestinal cancers
2: Neurological complications of GI cancers
3: Common systemic treatment regimens for GI cancers and their neurological complications
References
Chapter 23: Neurologic complications associated with genitourinary cancer
Abstract
1: Introduction
2: Prostate cancer
3: Uterus
4: Ovarian cancer
5: Renal carcinoma
6: Germ cell testicular cancer
7: Bladder carcinoma
8: Conclusion
References
Chapter 24: Sarcoma and the nervous system
Abstract
1: Introduction
2: Primary CNS sarcomas
3: Primary sarcomas of the peripheral nervous system
4: Extra-CNS sarcoma affecting the nervous system
5: CNS metastases from extra-CNS sarcoma
6: Neurologic toxicities from sarcoma treatments
7: Conclusions
References
Chapter 25: Neurological complications of multiple myeloma
Abstract
1: Introduction
2: Central nervous system complications
3: Peripheral nervous system complications
4: Conclusion
References
Chapter 26: Neurologic complications in the treatment of childhood malignancies
Abstract
1: Introduction
2: Part I: Acute complications of cancer treatment
3: Part II: Late effects of cancer treatment
4: Conclusion
References
Section IV: Neurological complications of antineoplastic therapy
Chapter 27: Neurological complications of radiation therapy
Abstract
1: Introduction
2: Pathophysiology of neurological complications from radiation
3: Radiation-induced brain toxicity
4: Radiation-induced complications of spinal cord
5: Radiation-induced nerve injury
6: Endocrinopathy after radiation therapy
7: Cerebrovascular complications after radiation treatment
8: Radiation-induced secondary malignancy
9: Conclusion
References
Chapter 28: Neurological complications of systemic cancer and antineoplastic therapy
Abstract
1: Introduction
2: Mechanisms of neurotoxicity
3: Neurotixicity of specific agents
4: Targeted therapies
5: Biological agents
6: Chemotherapy-induced cognitive impairment
7: Conclusion
References
Chapter 29: Neurological complications of hematopoietic stem cell transplantation
Abstract
1: Introduction
2: Neurologic complications associated with conditioning regimens
3: Toxic-metabolic encephalopathy
4: Cerebrovascular complications
5: CNS infections
6: Neurologic complications associated with chronic graft versus host disease (GVHD)
7: Neurologic complications associated with immunosuppressive therapy
8: Neurocognitive dysfunction
9: Secondary malignancies
10: Conclusion
References
Chapter 30: Chemotherapy-induced peripheral neuropathy
Abstract
1: Introduction
2: Pathophysiology of CIPN
3: Clinical presentation and diagnostic evaluation of CIPN
4: Clinical management of CIPN
References
Chapter 31: Neurological complications of immunotherapy and monoclonal antibody therapy
Abstract
1: Introduction
2: Bevacizumab
3: Cetuximab and other anti-EGFR mAbs
4: Trastuzumab
5: Rituximab and other anti-CD20 mAbs
6: Dinutuximab
7: Brentuximab vedotin
8: Polatuzumab vedotin
9: Enfortumab vedotin
10: Trastuzumab emtansine
11: Blinatumomab
12: Interleukin-2 (IL2)
13: Interferon alpha
References
Chapter 32: Neurologic complications of immune modulatory therapy
Abstract
1: Introduction
2: Epidemiology
3: Headache
4: Malignant cerebral edema
5: Peripheral nervous system
6: Central nervous system
7: CAR T cell-mediated neurotoxicity (immune effector cell-associated neurotoxicity syndrome)
8: Conclusion: Diverse presentation, kinetics, importance of multidisciplinary and early treatment, consideration of re-challenge
References
Chapter 33: Neurological complications of steroids and of supportive care
Abstract
Acknowledgment
1: Introduction
2: Corticosteroids
3: Seizures
4: Vascular complications
5: Analgesics
6: Antiemetics
7: Depression
8: Summary
References
Section V: Psychiatric, pain, psychosocial, and supportive care issues
Chapter 34: Psychiatric aspects of care in the cancer patient
Abstract
1: Introduction
2: Historical background
3: Common psychological responses to cancer
4: Epidemiology of psychiatric disorders in cancer patients
5: General principles of psychiatric assessment and treatment in patients with cancer
6: Delirium
7: Adjustment disorders
8: Anxiety disorders
9: Trauma and stressor-related disorders
10: Depressive disorders
11: Suicide assessment and management in cancer patients
12: Psychiatric considerations in cancer-related fatigue
13: Cancer survivors
14: Families issues and bereavement
15: Psychological issues for staff
References
Chapter 35: Chronic cancer pain syndromes and their treatment
Abstract
1: Bone pain
2: Pain syndromes of the viscera and miscellaneous tumor-related syndromes
3: Headache and facial pain
4: Neuropathic pain involving the peripheral nervous system
5: Paraneoplastic nociceptive pain syndromes
6: Chronic pain syndromes associated with cancer therapy
7: Clinical evaluation of the patients with difficult pain
References
Further reading
Chapter 36: Psychosocial issues in cancer patients with neurological complications
Abstract
1: Introduction
2: Neurocognitive concerns
3: Psychological concerns
4: Behavioral concerns
5: Social concerns
6: Disparity concerns
7: End-of-life concerns
8: Conclusion
References
Chapter 37: Supportive care
Abstract
1: Introduction
2: Novel antiangiogenic agents
3: Conclusion
References
Index