دانلود کتاب New Approaches to Drug Discovery

فهرست مطالب :

Front Matter....Pages i-viii
Trends in Modern Drug Discovery....Pages 3-22
Functional Genomics in Pharmaceutical Drug Discovery....Pages 25-41
Emerging Target Families: Intractable Targets....Pages 43-58
In Vivo Target Validation Using Biological Molecules in Drug Development....Pages 59-70
High-Throughput Synthesis of Diverse Compound Collections for Lead Discovery and Optimization....Pages 73-89
Sources for Leads: Natural Products and Libraries....Pages 91-123
New Compound Classes: Protein–Protein Interactions....Pages 125-138
Using Cheminformatics in Drug Discovery....Pages 139-168
Implementation and Use of State-of-the-Art, Cell-Based In Vitro Assays....Pages 171-190
Translational In Vivo Models for Women’s Health: The Nonhuman Primate Endometrium—A Predictive Model for Assessing Steroid Receptor Modulators....Pages 191-202
Predictive In Vivo Models for Oncology....Pages 203-221
Translational In Vivo Models for Cardiovascular Diseases....Pages 223-234
Pharmacokinetics in Drug Discovery: An Exposure-Centred Approach to Optimising and Predicting Drug Efficacy and Safety....Pages 235-260
Nonclinical Safety and Toxicology....Pages 261-283
Impact of Biomarkers on Personalized Medicine....Pages 285-311
Modeling and Simulation of In Vivo Drug Effects....Pages 313-329
Back Matter....Pages 331-341