دانلود کتاب Peptides: 17. Prague, Czechoslovakia, August 29–September 3, 1982

فهرست مطالب :

Preface\nContents\nEuropean Peptide Committee and Programme Committee\nHonorary Committee and Organizing Committee\nPrevious European Peptide Symposia\nList of Participants\nIn Memoriam, Emil Taschner\nIn Memoriam, Dieter Marquarding\nIn Memoriam, Erhard Gross\nPlenary Lectures\nRecent Developments in the Chemistry and Biology of Cyclic Peptides\nConformational Considerations in the Design of Highly Potent and Long-Acting Peptide Hormone Agonists and Antagonists\nSemisynthesis of Proteins and Peptides\nFurther Application of the Aqueous-Organic Two-Phase Approach to Enzyme-Catalyzed Peptide-Synthesis\nInteractions of Lipid Bilayers with Corticotropin, Dynorphin, and Enkephalin Peptides\nGramicidin A: From Structure Towards the Molecular Mechanism of Action\nStructural Comparisons of Retroenantiomeric Cyclic Hexapeptides\nCircular Dichroism and Conformation of Peptides Related to Oxytocin\nSynthesis of Peptides\nMethods of Protection\nAdaptation of Side Reactions for Peptide Synthesis\nA New Type of Reagents for the Liberation of free Amino Components\nThe Application of Recently Developed Amino Protecting Groups in Peptide Synthesis\nPreparation of 4-Sulfobenzyl Esters and their Use in Peptide Synthesis\nThe 2-Chloroethyl Group for Carboxyl Protection in Peptide Synthesis\nSome Properties of Amino Acid and Peptide Phenacyl Esters\nTemporary Substitution of Asparagine by Aspartic Acid in the Synthesis of Peptide Segments of Vasoactive Intestinal Peptide (VIP)\nMethods of Coupling\nRecycling of Excess Peptides from Fragment Condensations with Carbonyldiimidazole/1-Hydroxybenzotriazole Activation\nFatty Acids as Additives Suppressing Racemization of Amino Acid Residues in Peptide Synthesis by the DCC Method\nHPLC as a Tool for the Investigation of Peptide Bond Formation\nApplication of Phosphinic Acids to Peptide Synthesis\nA Reinvestigation of the Mixed Anhydride Method\nDo Acylamino Acid and Peptide Anhydrides Exist?\nFirst Results with New Reagents for Peptide Coupling\nPeptide Syntheses without Isolation of Intermediates Using Biphasic Solvent System\nSome Applications of the Curtius Rearrangement\nHeterodetic Bonds\nA New Method for the Selective Synthesis of Unsymmetrical Cystine Peptides\nA Controlled Synthesis of Cyclic Unsymmetrical Cystine Peptides Bearing Two S-S Bridges in the Ring\nSynthesis of Cysteine and Cystine Containing Peptides through 3-0-[N-Benzyloxycarbony 1-S-Acetamidomethyl- Cysteinyl] -Hydroxy-2-Phenylindenone\nMethod of Cyclization of Carba Analogues of Oxytocin\nSynthesis of Isopeptides of Lysine as Fundamental Structural Units of Clavicepamines\nSynthesis of Leucine Enkephalin- and Aspartame Analogs Containing Thioamide Linkages at Specific Positions\nSynthesis on Polymeric Supports\nSynthetic Studies on the Cecropins\nImproved Syntheses of Substance P and Analogues on a Phenolic Resin Support\nPeptide Ionophores. Synthesis and Characterization of Cyclic Octa- and Decapeptides Containing Leucine and Proline\nHistone Model Peptide Synthetized by Solid Phase Fragment Condensation\nThe Biomimetic Gel Phase Synthesis of the RNA-Polymerase II Inhibitor Peptide 6\'-Deshydroxy-Amanullin\nMethodological Studies on Gel Phase Synthesis of the Arginine-Rich Propeptide Extension of Proalbumin\nUse of the Nbb-Resin and 4-Hydroxymethylphenoxymethyl- Resin in Solid Phase Peptide Synthesis\nComparative Syntheses of an Octapeptide Using Continuous Flow (Column) and Conventional Polyamide Solid Phase Methods\nThe Solid Phase Synthesis of Neurotensin and Related Peptides on Polydimethylacrylamide Resins\nLiquid-Phase Synthesis of Biologically Active Peptides on Easily Detachable Poly(Ethylene Glycol) Supports\nSynthesis of Individual Peptides\nSynthesis of Tuftsin under HPLC Control\nSynthesis of Tuftsin Analogs with Elongated Peptide Chain and a Possible Anticancer Activity\nSynthesis of an IgG Fragment Decapeptide and Preliminary Evaluation of its Role on Phagocytosis Stimulation of Human Polymorphonuclear Leukocytes\nSynthesis and Pharmacologic Characterization of Glucagon (1-21)-Peptide\nThe Synthesis of Peptides Related to Prothrombin\nTotal Synthesis of Neurotoxin II from the Central Asian Cobra (Naja naja oxiana) venom\nSynthesis of Labelled Peptides\nCatalytic Exchange Labelling of Peptides\nSolid Phase Synthesis of Neurotensin Analogues Susceptible to Radiolabelling\nTritium Incorporation into Histidine by Direct Catalytic Exchange: Labelling of Gonadotropin Releasing Hormone and Analogs\nThe ³H-Labelling of Peptides by Reduction of Dehydroleucine\nAnalogues of [8-ArginineJ Vasopressin for Hormone Receptor Research\nSynthesis of Peptides Containing Non-Coded Amino Acids\nSynthetic Fragments of Bacterial Cell Walls. Physicochemical and Biological Properties\nSynthesis of Analogues of Precursors of Bacterial Peptidoglycan\nSynthesis of Peptides with α, β-Dehydroaminoacid Residue\nSynthesis of Dehydro Amino Acids and Peptides\nα-Hydroxymethylation of Peptides: A Synthetic Route to Peptides Containing α-Hydroxymethy1-Amino Acids\nL- α-Aminoadipic Acid δ-N-Benzyloxycarbonylamide and its Use in Peptide Synthesis\nSynthesis of ß-Homo-L-Proline Analogues of Peptide Hormones\nOptically Active Neopentylglycine and its Applications in Peptide Chemistry\nMonodisperse Conjugates of Catecholamines\nTotal Synthesis of Althiomycin\nPeptide Tricyclic Thia-Cyclols from Linear Precursors\nSemi-Synthesis\nSynthesis of Cytochrome C-(66-104) Nonatriacontapeptide and Analogues\nCytochrome c̱ Semisynthesis Using Enzymic Resynthesis Techniques\nSemisynthetic Analogs of Globomycin\nSemisynthetic Studies on the Bovine Trypsin-Kallikrein Inhibitor\nSynthesis of a Hybrid Chicken/Human Insulin\nSemisyntheses of Insulin Analogues by Replacement of the Sequence Al-4\nSynthesis of Peptides Using Enzymes\nEnzymatic Peptide Synthesis\nAmidation of Synthetic Peptides by Pituitary Enzyme: Specificity and Mechanism of the Reaction\nReaction Mechanism in Trypsin Catalyzed Synthesis of Human Insulin Studied by ¹⁷O-NMR Spectroscopy\nTrypsin-Catalyzed Oligomerization of the Ala-Ala-Arg Tripeptide\nThermitase-Catalyzed Hydrolysis of the C-Terminal Ester Group of Protected Peptide Ester Derivatives\nReversibility of Tryptic Hydrolysis in a Model Nonapeptide Sequence\nSynthesis and Characterization of α- and/or ε-Substituted Lysine Peptides\nPurification, Characterization and Analytics\nIsolation by Preparative HPLC and Characterization of Major Components after Cyclization of a Decapeptide\nSeparation of Basic, Hydrophilic Peptides by Reversed- Phase Ion-Pair Chromatography. III. A Progress Report\nPre-Column Derivatization in HPLC of Peptides\nFast Atom Bombardment Mass Spectrometry - a New Tool for Peptide Sequence Analysis\nProgress Towards a Post-Synthetic Chiral Analysis of Peptides\nDirect Peptide Sequencing after TLC on Silica Gel without Substance Elution\nStructure-Activity Relations\nNeurohypophyseal Hormones\nTwo Analogues of Oxytocin with Modified Proline Cyclic Structure\nSynthesis of new Active and Highly Selective Analogues of Oxytocin and Arginine-Vasopressin\nCNS - Active Vasopressin Analogues\nInvestigation of Position 2 and 3 of Vasopressins\nAnalogues of Neurohypophysial Hormones Containing a D-Amino Acid in Position 2\nPenicillamine-Containing Analogues of Neurohypophysial Hormones\n9-Substituted Vasopressin Analogs with Substantial Antidiuretic Activity\nInteractions of Deamino-6-Carba-0xytocin Analogues in Rat Kidney and Liver Membrane Systems\nOpioid Peptides\nSynthesis and Biological Activity of New Enkephalin Analogues\nBiochemical and Pharmacological Investigations of Peripheral and Brain δ-Opiate Receptors Using Tyr-D-Thr-Gly- Phe-Leu-Thr, a New Fully Specific 6-Ligand\nDouble Opiate Peptides. A Hypothesis of Two Different Mechanisms of Opiate Actions\nSynthesis and Activity of Kyotorphin and its Analogs\nOpioid Activity of Synthetic \"Small Demorphins\"\nStructure-Activity Relationship of Dermorphin\nStructural Modifications of β-Casomorphin-5: Synthesis and Pharmacology\nSubstance P\nSubstance P: The \"Yin-Yang\" of Behavior?\nHydrophilic Analogs of Substance P: Introduction of Sugar Acids and Sulfonium Groups\nInfluence of the Methionine Sidechain on the Biological Activity of Substance P\nSubstance P Analogues Containing Para-Substituted Phenylalanine: Synthesis and Pharmacological Properties\nSynthesis of Potent and Specific Antagonists of Substance P\nSubstance P: Inactivation in CNS, Enzymatically Resistant Analogue and Development of \"Brain Selective\" Agonist\nOther Biologically Active Peptides\nSome Pharmaceutical Aspects of Peptide Research\nThe Synthesis and Gonadotropic Activity of [D-Tle⁶, Pro-NH-Et⁹]LRF\nThe Role of N-Acyl Groups in the Inhibitory Activity of LH-RH Analogues\nGonadotropin Releasing Hormone and its Analogs Desensitize Pituitary GnRH Action\nDSIP: Novel Developments in Structure-Functional Studies\nThe Active Centres of Gastrin and Cholecystokynin: Syntheses, Conformational Problems, Correlation between Chemical Structure and Biological Activity\nWhat is the Minimum Active Centre of Gastrin?\nStructure-Activity Relationships of Highly Potent and Specific Gctapeptide Analogues of Somatostatin\nPhotoreactive [Leu⁹]-a-MSH Derivatives for Receptor Labelling\nDegradation of α-Melanotropin by the Enzymes of the Soluble Fraction of Rat Brain Homogenate\nSolid Phase Synthesis of Amunine (CRF), Sauvagine and Two Urotensin I\nProctolin: Synthesis, Enzymatic Degradation and Effect on the Cyclic Nucleotide System\nPhosphonopeptides, Novel Inhibitors of Bacterial Cell Wall Biosynthesis\nUrinary Excretion of Biologically Active Peptides and/or Peptide-Like Material in Various Disorders\nInhibitors and Binding Studies\nSynthesis and Properties of Peptide Ketones\nEnkephalin Diazomethyl and Chloromethyl Ketones: Synthesis and Biological Activity\nUse of Quantitative Lipophilicity Relationships for the Design of Renin Inhibitors\nSpecific Inhibitors of Renin\nAnionic Inhibitors of Elastase\nInhibition of Thrombin with H- and Boc-D-Phe-Pro-Agm\nAnalogues of Chymostatin\nBinding Studies of Glucagon Antagonists\nDetermination of the Toxic and Antigenic Sites of Peptide Snake Venom Short Neurotoxins\nDesign and Synthesis of Two Peptides as Models for the Antigenic Sites of the Toxin II of the Scorpion Androctonus australis Hector\nImmunology Related Peptides\nChemical Approaches to Improve Immunoassays of Peptide Hormones\nAntineoplastic and Immunogenic Effects of Tuftsin (Thr-Lys-Pro-Arg) and its Analogs\nSynthesis and Biological Assays of Peptides from a Tuberculin-Active Protein\nSynthesis and Immunoreactivity of Escherichia Coli Heat Stable Enterotoxins Analogs\nPreparation and Antigenicity of the C-Terminal Fragments of Human Leukocyte Interferons α2 and α1\nImmunological Properties of Hapten-Peptide Conjugates: The Effect of Size, Lipophilic Substituents and Haptenic Distance on Tolerogenicity and Anaphylactogenicity\nConformational Studies\nConformation: Model Peptides\nConformational Features of Alternating L, D Peptides\nConformation of Cyclic Hexapeptides Studied by the Modified Factor Analysis of Circular Dichroism Spectra\nConformational Energy Calculations of Heterodetic Cyclic Hexapeptides Related to Oxytocin Ring Moiety\nConformational Energy Analysis of Oxytocin Molecule\nConformational Analysis of Peptides Substrate of N-Glycosylation\nSerine and ß-Folding\nX-Ray Structure and Conformation in Solution of Peptides Containing α-Aminoisobutyric Acid Residues\nPreferred Conformations of Host-Guest Peptides\nConformation: Biologically Active Peptides\nConformation Calculations and Biologically Active Conformations of Cyclopeptides\nPeptaibol Antibiotics: A Study on the Helical Structure of Emerimicins\nConformational and Ionophoric Properties of Prolyl Containing Analogs of Valinomycin\nSynthesis of the Postulated Calcium Binding Site I of Calmodulin and Binding Studies\nX-Ray Structural Study of Ionophores of a Valinomycin Group\nConformational Studies on Gaba-Enkephalinamides\nConformational Studies of the \"in vitro\" Potent Opiate [D-Met², Trp⁴, Pro⁵] Enkephalinamide by Fluorescence and Theoretical Calculations\nConfiguration of the Azo Bridge in Azo-Enkephalin\nSelf-Association of Substance P and its C-Terminal Sequences\nSpatial Structure of Bradykinin Potentiating Peptide BPP_9α\nGuest-Host Relationship in Bradykinin Peptides\nImportance of Residue 5 in Antiotensin II\nCircular Dichroism Aids Interpretation of Structure- Activity Relationship of Somatostatin Analogs\nThe Conformational Equilibrium of the Peptide Hormone Somatostatin and some Analogues in Aqueous Solution\nApplication of Homonuclear and Heteronuclear Two-Dimensional NMR Spectroscopy to Cyclolinopeptide A (1)\nRole of the N-Terminal Fragment on the Stability of the Porcine Pancreatic Secretory Tryps in Inhibitors (KAZAL)\nRelationship between the Steric Structure of Insulin Derivatives and their Biological Activity\nStudies of Hydrogen Bonding in Relation to Oxytocin Activity\nSynthesis, Conformation and Interaction with a Decanucleotide of the Fragment (26-39) of the \"Cro\" Protein from Bacteriophage λ\nAbbreviations\nSubject Index\nAuthors\' Index