دانلود کتاب Pharmaceutical Dosage Forms vol 1: Disperse Systems

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Cover......Page 1
Half Title......Page 2
Title Page......Page 4
Copyright Page......Page 5
Preface to the Second Edition......Page 6
Preface to the First Edition......Page 8
Table of Contents......Page 10
Contributors......Page 14
Contents of Volumes 2 and 3......Page 16
Contents of Pharmaceutical Dosage Forms: Tablets, Second Edition, Revised and Expanded, Volumes 1-3......Page 18
Contents of Pharmaceutical Dosage Forms: Parenteral Medications, Second Edition, Revised and Expanded, Volumes 1-3......Page 20
I. Overview......Page 22
II. Free Energy Considerations......Page 24
III. Stability Considerations......Page 29
IV. Protocols......Page 34
References......Page 35
II. Classification of Dispersed Systems......Page 38
III. Particle Properties......Page 39
IV. The Solid-Liquid Interface......Page 47
V. Preparation......Page 51
VI. Stabilization......Page 53
VII. Rheological Aspects......Page 64
VIII. Effect of Additives......Page 67
Appendix I: Typical Particle Size Devices......Page 69
Appendix II: Mixing Equipment: Manufacturers and Devices......Page 70
References......Page 71
I. Introduction......Page 74
II. General Aspects of Emulsions......Page 75
III. Stability of Two-Phase Emulsions......Page 81
IV. Stability of Three-Phase Emulsions......Page 96
Appendix: Flocculation Kinetics of Spherical Particles or Droplets......Page 108
References......Page 110
I. Introduction......Page 112
II. Electrostatic Stabilization of Latexes......Page 114
III. Steric Stabilization of Latexes......Page 133
IV. Preparation of Latexes by Direct Emulsification......Page 146
References......Page 163
I. Introduction......Page 174
II. Fundamentals......Page 175
III. Elasticity and Viscosity......Page 177
IV. Viscometry......Page 200
V. Rheology of Dispersed Systems......Page 219
References......Page 228
I. Definitions and General Properties of Surfactants......Page 232
II. Physical Description of Surfactants in Solution......Page 234
III. Chemical Description of Surfactants......Page 247
IV. Special Topics......Page 271
V. Biological Effects of Surfactants......Page 280
VI. Use of Surfactants in Drug Products......Page 286
VII. Effect of Surfactants on Drug Efficacy......Page 292
Appendix: Practical Examples......Page 298
References......Page 302
I. Introduction......Page 308
II. Polymer Solution Rheology......Page 309
III. Sedimentation Control in Disperse Systems......Page 310
IV. Viscosity Changes During Product Aging......Page 311
V. Flocculation and Deflocculation Phenomena......Page 312
VI. Excipient Compatability......Page 315
VII. Polymer Selection......Page 316
VIII. Viscosity-Building Substances......Page 317
IX. Sample Formulations......Page 330
References......Page 333
I. Introduction......Page 336
II. Formulation Factors Affecting Drug Release from Disperse Systems......Page 337
III. Principles of Drug Release from Disperse Systems......Page 338
IV. In Vitro-In Vivo Correlations......Page 345
V. Physiological Factors Affecting Bioavailability......Page 346
VI. Methods of Assessing Drug Bioavailability......Page 349
VII. In Vivo Bioavailability Assessment......Page 359
References......Page 391
I. Overview......Page 398
II. General Characteristics......Page 400
III. Microbial Contamination......Page 403
IV. Preservatives......Page 409
V. Effects of Product Ingredients on Preservative Activity......Page 428
VI. Evaluation of Preservative Efficacy......Page 433
VII. Future Trends......Page 446
References......Page 451
I. Introduction......Page 458
II. Deterministic Modeling......Page 459
III. Stochastic Modeling......Page 528
IV. Concluding Remarks......Page 534
References......Page 535
Index......Page 542