توضیحاتی در مورد کتاب :
این کتاب ویژه برای برجسته کردن یکپارچگی ساختاری و عملکردی میتوکندری و چگونگی ارتباط آنها با چندین بیماری انسانی مانند بیماری های قلبی عروقی، سرطان، کلیوی، اختلالات عصبی و اختلالات ژنتیکی طراحی شده است. از طریق راهبردهای دارویی جدید از طریق میتوکندری برای درک نقش فیزیولوژیکی و پاتولوژیک آنها و همچنین ارائه آنها به عنوان اهداف درمانی"--توضیحات ناشر. بیشتر بخوانید... چکیده:
این کتاب ویژه برای برجسته کردن ساختار و ساختار میتوکندری طراحی شده است. یکپارچگی عملکردی و نحوه ارتباط آنها با چندین بیماری انسانی مانند قلبی عروقی، سرطان، کلیوی، اختلال عصبی، و اختلالات ژنتیکی. بیشتر بخوانید...
فهرست مطالب :
Front Matter ....Pages i-xi
Nuclear Transcription Factors in the Mitochondria: A New Paradigm in Fine-Tuning Mitochondrial Metabolism (Naresh Babu V. Sepuri, Prasad Tammineni, Fareed Mohammed, Arunkumar Paripati)....Pages 3-20
The Mitochondrial Permeability Transition Pore and ATP Synthase (Gisela Beutner, Kambiz N. Alavian, Elizabeth A. Jonas, George A. Porter Jr)....Pages 21-46
The Roles of Mitochondrial Cation Channels Under Physiological Conditions and in Cancer (Ildikò Szabò, Luigi Leanza)....Pages 47-69
Anion Channels of Mitochondria (Devasena Ponnalagu, Harpreet Singh)....Pages 71-101
Guide to the Pharmacology of Mitochondrial Potassium Channels (Bartłomiej Augustynek, Wolfram S. Kunz, Adam Szewczyk)....Pages 103-127
The Mitochondrial Ca2+ Uniporter: Structure, Function, and Pharmacology (Jyotsna Mishra, Bong Sook Jhun, Stephen Hurst, Jin O-Uchi, György Csordás, Shey-Shing Sheu)....Pages 129-156
Mitochondrial Fission in Human Diseases (Madhavika N. Serasinghe, Jerry E. Chipuk)....Pages 159-188
Mitochondrial Cholesterol and the Paradox in Cell Death (Carmen García-Ruiz, Vicente Ribas, Anna Baulies, Jose C. Fernández-Checa)....Pages 189-210
Mitochondrial Changes in Cancer (Shubha Gururaja Rao)....Pages 211-227
The Emerging Role of Mitochondrial Targeting in Kidney Disease (Alfonso Eirin, Amir Lerman, Lilach O. Lerman)....Pages 229-250
Mitochondrial Dynamics as a Therapeutic Target for Treating Cardiac Diseases (Sang-Bing Ong, Derek J. Hausenloy)....Pages 251-279
Mitochondria in Alzheimer’s Disease and Diabetes-Associated Neurodegeneration: License to Heal! (Susana M. Cardoso, Sónia C. Correia, Cristina Carvalho, Paula I. Moreira)....Pages 281-308
Leber Hereditary Optic Neuropathy: A Mitochondrial Disease Unique in Many Ways (Rui Bi, Ian Logan, Yong-Gang Yao)....Pages 309-336
Leber Hereditary Optic Neuropathy: Exemplar of an mtDNA Disease (Douglas C. Wallace, Marie T. Lott)....Pages 339-376
Equipping Physiologists with an Informatics Tool Chest: Toward an Integerated Mitochondrial Phenome (Anders Olav Garlid, Jennifer S. Polson, Keith D. Garlid, Henning Hermjakob, Peipei Ping)....Pages 377-401
Mitochondrial Flashes: Elemental Signaling Events in Eukaryotic Cells (Gaomin Feng, Beibei Liu, Tingting Hou, Xianhua Wang, Heping Cheng)....Pages 403-422
Mitochondria-Targeted Agents: Mitochondriotropics, Mitochondriotoxics, and Mitocans (Diana Guzman-Villanueva, Volkmar Weissig)....Pages 423-438
Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function (Hiroko P. Indo, Clare L. Hawkins, Ikuo Nakanishi, Ken-ichiro Matsumoto, Hirofumi Matsui, Shigeaki Suenaga et al.)....Pages 439-456
MITO-Porter for Mitochondrial Delivery and Mitochondrial Functional Analysis (Yuma Yamada, Hideyoshi Harashima)....Pages 457-472
Toxicity of Antiepileptic Drugs to Mitochondria (Josef Finsterer)....Pages 473-488
Erratum to: The Mitochondrial Permeability Transition Pore and ATP Synthase (Gisela Beutner, Kambiz N. Alavian, Elizabeth A. Jonas, George A. Porter Jr)....Pages 489-489
Back Matter ....Pages 491-493
توضیحاتی در مورد کتاب به زبان اصلی :
"This special book is conceived to highlight mitochondrial structural and functional integrity and how they are associated with several human diseases such as cardiovascular, cancer, renal, neurological disorder, and genetic disorders. The chapters contributed by leading mitochondrial researchers in the handbook will take us through the novel pharmacological strategies via mitochondria to understand their physiological and pathological role as well as present them as therapeutic targets"--Publisher's description. Read more... Abstract:
This special book is conceived to highlight mitochondrial structural and functional integrity and how they are associated with several human diseases such as cardiovascular, cancer, renal, neurological disorder, and genetic disorders. Read more...