دانلود کتاب Physiology and Pathophysiology of the Islets of Langerhans

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Front Matter....Pages i-x
Front Matter....Pages 1-1
Why are Islets so Important?....Pages 3-10
Front Matter....Pages 11-11
Hexose Recognition by the Pancreatic β-Cell and the Gustatory Cell....Pages 15-20
Glucose-Induced Time-Dependent Potentiation and “Run Down” of Insulin Secretion in Islets of Young Rats....Pages 21-26
ATP-Sensitive K + Channel Closure is not an Obligatory Step for Glucose-Induced Priming of Pancreatic B-Cell....Pages 29-31
Bursting Electrical Activity Generated in the Presence of K ATP Channel Blockers....Pages 33-41
Modulation of Three Types of Potassium Selective Channels by NAD and Other Pyridine Nucleotides in Human Pancreatic β-Cells....Pages 43-50
Novel Actions of the Potassium Channel Modulator SDZ PCO 400 on ATP-Regulated Potassium Channels in Insulin Secreting Cells....Pages 51-58
Effects of Protein Phosphorylation on the Sulphonylurea Receptor of the Pancreatic β-Cell....Pages 59-69
Intracellular Second Messengers....Pages 73-80
Immunological Analysis of G-Protein Expression in the Endocrine Pancreas....Pages 81-84
Calcyclin, a Calcium-Binding Protein, which Regulates Insulin Secretion from the Permeabilized Pancreatic β-Cell....Pages 85-89
Molecular Cloning of the cDNA Encoding β-Cell Calcium/Calmodulin-Dependent Protein Kinase II....Pages 91-96
Trans-Acting Factor(s) Confer Glucose-Responsive Transcriptional Regulation in the Insulin Gene....Pages 97-100
Front Matter....Pages 101-101
Extracellular Messages for Pancreatic B-Cells....Pages 103-112
The Human Glucagon-Like Peptide-1 (GLP-1) Receptor....Pages 113-119
Islet Release of ACTH-Like Peptides and their Modulatory Effect on Insulin Secretion....Pages 121-127
Chronic Sympathetic Innervation of Islets in Transgenic Mice Results in Differential Desensitization of α-Adrenergic Inhibition of Insulin Secretion....Pages 129-138
Colocalization of WE-14 Immunostaining with the Classical Islet Hormones in the Porcine Pancreas....Pages 139-144
Pyridothiadiazines as Potent Inhibitors of Glucose-Induced Insulin Release....Pages 145-148
Increase in [Ca 2+ ] i and Subsequent Insulin Release from βTC3-Cells with the L-Type Ca 2+ -Channel Activator, FPL 64176....Pages 149-157
Front Matter....Pages 101-101
Identification and Characterization of Non-Adrenergic Binding Sites in Insulin-Secreting Cells with the Imidazoline RX821002....Pages 159-163
PACAP as Low as 10 −13 M Raises Cytosolic Ca 2+ Activity in Pancreatic B-Cells by Augmenting Ca 2+ Influx Through L-Type Ca 2+ Channels to Trigger Insulin Release....Pages 165-171
Characterization of Purinergic Receptor-Evoked Increases in Intracellular Ca 2+ Transients in Isolated Human and Rodent Insulin-Secreting Cells....Pages 173-179
Front Matter....Pages 181-181
Reciprocal Links Between Metabolic and Ionic Events in Islet Cells....Pages 183-188
Glyceraldehyde and the Pancreatic β-Cell....Pages 189-193
Oscillations of Cytosolic Ca 2+ in Pancreatic Islets of Langerhans....Pages 195-202
Effects of Localized Pulses of High K + and Carbachol on [Ca 2+ ] i in Pancreatic Islets of Langerhans....Pages 203-209
Cyclic AMP, a Mediator of GLP-1, Acts in Concert with Glucose and Tolbutamide to Increase Cytosolic Ca 2+ in Pancreatic B-Cells....Pages 211-216
Metabolism of Phosphatidylcholine in Mouse Pancreatic Islets....Pages 217-221
Phe—Met—Arg—Phe—NH 2 (FMRFa)-Related Peptides Inhibit Na/Ca Exchange in Pancreatic B Cells....Pages 223-225
Cell Culture Conditions Influence Glucose-Induced [Ca 2+ ] i Responses in Isolated Rat Pancreatic B Cells....Pages 227-230
Stimulation of Insulin Release In Vivo by the Methyl Esters of Succinic Acid and Glutamic Acid....Pages 231-234
Glucose Metabolism Regulates Cytosolic Ca 2+ in the Pancreatic β-Cell by Three Different Mechanisms....Pages 235-243
Front Matter....Pages 245-245
Heterogeneity of β-Cell Secretion....Pages 247-252
Heterogeneity of β-Cell Ca 2+ Responses to Glucose....Pages 253-257
Glucose-Induced B-Cell Recruitment and the Expression of Hexokinase Isoenzymes....Pages 259-266
Physiological Behavior of Functional Subpopulations of Single Pancreatic β-Cells....Pages 267-274
Computer Modeling of Heterogeneous β-Cell Populations....Pages 275-284
Reconstructing Islet Function In Vitro ....Pages 285-298
Front Matter....Pages 299-299
New Aspects to the Functioning and Regeneration of Pancreatic β-Cells....Pages 301-311
Front Matter....Pages 299-299
A Role for Nitric Oxide and Other Inflammatory Mediators in Cytokine-Induced Pancreatic β-Cell Dysfunction and Destruction....Pages 313-319
The Reg Gene and Islet Cell Repair and Renewal in Type 1 Diabetes....Pages 321-327
DNA-Damage and NAD + -Depletion are Initial Events in Oxygen Radical Induced Islet Cell Death....Pages 329-334
Nitric Oxide Rather than Superoxide or Peroxynitrite Inhibits Insulin Secretion and Causes DNA Damage in HIT-T15 Cells....Pages 335-339
Activation of Peritoneal Macrophages During the Prediabetic Phase in Low-Dose Streptozotocin-Treated Mice....Pages 341-343
Immunological Reactivity of Diabetes-Prone BB/OK Rats to Syngeneic Antigens....Pages 345-353
Effects of Oxidants on Membrane Potential, K + and Ca 2+ Currents of Mouse Pancreatic B-Cells....Pages 355-359
Front Matter....Pages 361-361
IAPP and Insulin Regulation in Human Pancreatic Islets....Pages 363-369
Hyperproinsulinaemia and Islet Dysfuction in the NIDDM-Like Syndrome of Psammomys obesus ....Pages 371-378
Altered Secretory Responsiveness of Brin-BD11 Cells Cultured under Hyperglycaemic Conditions is not Readily Reversed by Subsequent Culture in Lower Glucose Concentrations....Pages 379-384
B-Cell Hyperresponsiveness to Glucose in NIDDM During Prediabetes....Pages 385-387
Insulin Treatment Prevents Adaptation of the Endocrine Pancreas to Pregnancy....Pages 389-393
Front Matter....Pages 395-395
Islet Transplantation....Pages 397-410
The Syngeneic Islet Transplantation to Study Physiology and Pathophysiology of Pancreatic β-Cells....Pages 411-419
Beta Cell Replication and Mass in Islet Transplantation....Pages 421-427
Islet Growth After Pancreatic Fragments Autotransplantation into the Dog’s Spleen....Pages 429-433
The use of Immunomagnetic Separation for Secondary Purification of Pancreatic Islets....Pages 435-440
Transplantation of Syngenic Pancreatic Islets into Rats with Streptozotocin Induced Non Insulin Dependent Diabetes Mellitus....Pages 441-445
Effects of Caffeine on Glucose-Stimulated Insulin Release from Islet Transplants....Pages 447-452
Back Matter....Pages 453-457