دانلود کتاب Polymorphism in Pharmaceutical Solids, Second Edition (Drugs and the Pharmaceutical Sciences)

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Preface......Page 8
Contents......Page 10
Contributors......Page 12
1. Theory and Principles of Polymorphic Systems......Page 14
2. Application of the Phase Rule to the Characterization of Polymorphic and Solvatomorphic Systems......Page 37
3. Computational Methodologies: Toward Crystal Structure and Polymorph Prediction......Page 65
4. Classical Methods of Preparation of Polymorphs and Alternative Solid Forms......Page 89
5. Approaches to High-Throughput Physical Form Screening and Discovery......Page 152
6. Structural Aspects of Polymorphism......Page 198
7. Structural Aspects of Solvatomorphic Systems......Page 246
8. Pharmaceutical Co-crystals: A New Opportunity in Pharmaceutical Science for a Long-Known but Little-Studied Class of Compounds......Page 295
9. Thermoanalytical and Crystallographic Methods......Page 331
10. Vibrational Spectroscopy......Page 360
11. Solid-State Nuclear Magnetic Resonance Spectroscopy......Page 394
12. Effects of Polymorphism and Solid-State Solvation on Solubility and Dissolution Rate......Page 449
13. Solid-State Phase Transformations......Page 494
14. Effects of Pharmaceutical Processing on the Solid Form of Drug and Excipient Materials......Page 523
15. Structural Aspects of Molecular Dissymmetry......Page 573
16. Amorphous Solids......Page 600
Index......Page 644