دانلود کتاب Principles of Pathophysiology

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Front cover
Front matter
Half title
Full title
Imprint
Brief table of contents
Detailed table of contents
About the authors
Preface
Acknowledgements
Features of the text
Educator resources
Part 1 Cellular and tissue pathophysiology
1 Pathophysiological terminology, cellular adaptation and injury
Introduction
Important terminology
Cellular responses to stimuli
Cellular adaptations
Maladaptive cellular adaptation
Cellular injury
Agents of cell injury
2 Determinants of health and illness
Introduction
Determinants of health and illness
Disease burden and mortality
Individual factors influencing health
Sociocultural and socioeconomic determinants of health
Environmental determinants of health
The Australian context
3 Inflammation and healing
Introduction
Acute inflammation
Chronic inflammation
Healing and repair
4 Genetic disorders
Introduction
Principles of genetic inheritance
Clinical diagnosis
Autosomal dominant inheritance
Autosomal recessive inheritance
X-linked inheritance
Chromosomal abnormalities
Threshold and penetrance
Principles of multifactorial inheritance
Congenital malformations
5 Neoplasia
Introduction
Epidemiology of cancer
Carcinogenicity and cancer
Characteristics of cancer cells
Tumour invasion and metastasis
Classification of tumours
Clinical manifestations of cancer
Screening, diagnosis and management
Part 2 Body defences and immune system pathophysiology
6 Stress and its role in disease
Introduction
Stressors
Historical perspectives on the stress response
Current perspectives on the stress response
Ageing and the stress response
Sex differences in the stress response
7 Immune disorders
Introduction
An overview of immune function
Types of immune dysfunction
Immune overactivity
8 Infection
Introduction
Infectious organisms
Types of colonisation by microorganisms
Chain of transmission
Antimicrobial drugs
Emerging infectious diseases
Part 3 Nervous system pathophysiology
9 Brain and spinal cord dysfunction
Introduction
Consciousness
Cerebrovascular accidents
CNS infections
Guillain-Barré syndrome
Hydrocephalus
Cerebral palsy
Cerebellar disorders
Neural tube defects
10 Neurodegenerative disorders
Introduction
Common pathophysiological processes implicated in neurodegeneration
Parkinson’s disease
Alzheimer’s disease
Huntington’s disease
Multiple sclerosis
Motor neurone disease
11 Neurotrauma
Introduction
Traumatic brain injury (TBI)
Spinal cord injury
12 Seizures and epilepsy
Introduction
Seizures
13 Nociception and pain
Introduction
Epidemiology of pain
Nociception and pain
Pain assessment
Neuropathic pain
Clinical diagnosis and management of pain
14 Disorders of the special senses
Introduction
Vision impairment
Hearing impairment
Balance and vestibular disorders
15 Mental health disorders
Introduction
Mental health and illness classified
Factors influencing mental health and wellness
Brain regions involved in affect, cognition and behaviour
Affective disorders
Anxiety disorders
Microbiome-gut-brain axis
Psychosis
Substance dependence and behavioural addictions
Dual diagnosis
part 4 Endocrine pathophysiology
16 Concepts of endocrine dysfunction
Introduction
The importance of endocrine feedback mechanisms
Types of pathophysiological mechanisms
Methods used to assess endocrine function
Principles of treatment
17 Hypothalamic-pituitary disorders
Introduction
Growth hormone
Prolactin hypersecretion
Antidiuretic hormone
Multi-hormone pituitary disruptions
18 Thyroid and parathyroid disorders
Introduction
Thyroid disorders
Parathyroid disorders
19 Adrenal gland disorders
Introduction
Disorders of the adrenal cortex
Disorders of the adrenal medulla
20 Diabetes mellitus
Introduction
Type 1 diabetes mellitus
Type 2 diabetes mellitus
Gestational diabetes
Clinical manifestations and complications of diabetes
Clinical diagnosis and management of diabetes mellitus
Part 5 Cardiovascular pathophysiology
21 Blood disorders
Introduction
Anaemias
Decreased production of erythrocytes
Increased destruction of erythrocytes: extracellular causes
Increased destruction of erythrocytes: intracellular causes
Loss of erythrocytes from blood loss
Polycythaemias
Haemophilias
Thrombocytopenia
Leukaemia and lymphoma
Multiple myeloma
22 Vascular disorders and circulatory shock
Introduction
Hypertension
Common conditions affecting arteries
Aneurysms
Arteriovenous malformations
Common conditions affecting veins
Thrombophlebitis and phlebothrombosis
Circulatory shock
23 Coronary artery disease
Introduction
Coronary artery disease
Acute coronary syndrome
24 Cardiac muscle and valve disorders
Introduction
Heart failure
Other causes of heart failure
Heart failure: risk factors, clinical manifestations, complications and diagnosis and management
25 Dysrhythmias
Introduction
Aetiology and pathophysiology
Clinical manifestations
Clinical diagnosis and management
Part 6 Pulmonary pathophysiology
26 Pulmonary dysfunction
Introduction
Respiratory rate, rhythm and depth
Alterations in oxygen and carbon dioxide levels
Pulmonary dysfunction
Respiratory assessments and investigations
Respiratory failure
27 Obstructive pulmonary disorders
Introduction
Asthma
Status asthmaticus
Bronchitis
Emphysema
Mechanisms of gas trapping
Cystic fibrosis
Bronchiectasis
28 Restrictive respiratory disorders
Introduction
Parenchymal lung disorders
Extraparenchymal lung disorders
29 Respiratory infections, cancers and vascular conditions
Introduction
Respiratory infections
Upper respiratory tract infections
Lower respiratory tract infections
Lung cancer
Pulmonary vascular conditions
Part 7 Fluid, electrolyte and renal pathophysiology
30 Fluid imbalances
Introduction
Distribution of body water and fluid balance
Compartment osmolality
Alterations in body fluid levels
Fluid deficits
Fluid excesses
31 Electrolyte imbalances
Introduction
Distribution of electrolytes
Electrolyte imbalances
32 Common inflammatory disorders of the kidneys and urinary tract
Introduction
The normal kidneys
Bacterial urinary tract infections
Kidney disorders
Urinary incontinence
33 Renal neoplasms and obstructions
Introduction
Polycystic kidney disease
Renal system cancers
Renal obstructions
34 Acute kidney injury and chronic kidney disease
Introduction
Acute kidney injury
Chronic kidney disease
Part 8 Gastrointestinal pathophysiology
35 Gastro-oesophageal reflux disease and peptic ulcer disease
Introduction
Gastro-oesophageal reflux disease
Peptic ulcer disease
36 Malabsorption syndromes
Introduction
Maldigestion
Impaired mucosal function
Alterations in microbial flora
37 Intestinal disorders
Introduction
Infectious conditions of the intestines
Acute inflammatory conditions of the intestines
Intestinal neoplasms
Chronic inflammatory bowel diseases
Intestinal obstruction
38 Disorders of the liver, gall bladder and pancreas
Introduction
An overview of the pathophysiology of hepatobiliary disease
Major hepatobiliary diseases
Major pancreatic diseases
Cystic fibrosis
Part 9 Reproductive pathophysiology
39 Female reproductive disorders
Introduction
Menstrual disorders
Genitourinary prolapse
Reproductive neoplasms
Female reproductive cancers
Inflammatory and infectious disorders
Breast disorders
Ectopic pregnancy
Female infertility
40 Male reproductive disorders
Introduction
Prostate disorders
Urethral and penile disorders
Testicular and scrotal disorders
Sexually transmitted infections
Part 10 Musculoskeletal pathophysiology
41 Musculoskeletal trauma and muscle disorders
Introduction
Musculoskeletal trauma
Fractures
Muscle disorders
Inflammatory myopathies
Muscular dystrophy
Muscle atrophy
Muscle contractures
Muscle cramp
Delayed onset muscle soreness (DOMS)
Rhabdomyolysis
42 Bone and joint disorders
Introduction
Bone and joint developmental disorders
Arthritis
Metabolic bone and joint diseases
Infective bone disorders
Osteogenic tumours
Part 11 Integumentary system pathophysiology
43 Integumentary system disorders
Introduction
inflammatory skin conditions
Skin infections
Viral infections
Fungal infections
Parasitic infections
Dermal appendage disorders
44 Skin cancers, burns and scarring
Introduction
Skin cancers
Burns
Scarring
45 Bites and stings
Introduction
Spider bites
Snake bites
Tick bites
Wasp and bee stings
Marine bites and stings
Glossary
Index