دانلود کتاب Prostaglandins and Leukotrienes in Gastrointestinal Diseases

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Front Matter....Pages I-XVII
Front Matter....Pages 1-1
Biosynthesis and Metabolism of Prostaglandins and Thromboxanes. Quantitative Determination in Biological Material....Pages 3-9
Discussion Following the Report of Prof. Granström....Pages 10-11
Involvement of the Eicosanoids, Thromboxane A 2 and Leukotriene C 4 in Gastric Mucosal Damage....Pages 12-19
Discussion Following the Report of Dr. Whittle....Pages 20-22
Microvascular Injury and the Role of Leukotrienes and Prostaglandins in Acute Mucosal Damage and Protection....Pages 23-29
Discussion Following the Report of Dr. Szabo....Pages 30-32
Inhibition of Prostaglandin Synthesis and Proliferation of the Gastric Mucosa....Pages 33-40
Discussion Following the Report of Prof. Halter....Pages 41-43
Role of Prostaglandins in Intestinal Fluid Secretion....Pages 44-47
Discussion Following the Report of Dr. Beubler....Pages 48-49
Novel Leukotriene D 4 Receptor Antagonists and 5-Lipoxygenase Inhibitors: Implications in Human Disease....Pages 50-54
Discussion Following the Report of Dr. Ford-Hutchinson....Pages 55-56
Front Matter....Pages 57-57
“Aggressive” and “Protective” Factors in the Pathogenesis of Peptic Ulcer Disease....Pages 59-64
Discussion Following the Report of Dr. Rees....Pages 65-65
Heartburn and Mucosal Barrier Weakness....Pages 66-72
Discussion Following the Report of Prof. Bernier....Pages 73-74
The Functional Role of Prostanoids in the Gastroduodenal Mucosa....Pages 75-80
Role of Leukotrienes in Gastric Mucosal Damage and Protection....Pages 81-87
Discussion Following the Report of Prof. Peskar....Pages 88-89
Effect of Prostaglandins on the Motility of the Digestive Tract....Pages 90-104
Front Matter....Pages 57-57
Discussion Following the Report of Dr. Demol....Pages 105-106
Gastroduodenal Bicarbonate Secretion in Mucosal Protection....Pages 107-111
Discussion Following the Report of Dr. Flemström....Pages 112-112
Prostaglandins and Cellular Restitution — Physiological and Pathological Implications....Pages 113-116
Discussion Following the Report of Prof. Miyake....Pages 117-117
Prostanoid Inhibition of Acid Secretion — Cellular Mechanisms in Canine Fundic Mucosa....Pages 118-126
Discussion Following the Report of Dr. Soll....Pages 127-128
The Protective Effects of Prostaglandins on the Gastric Microvasculature....Pages 129-139
Non-steroidal Anti-inflammatory Drugs and Peptic Ulcer....Pages 140-145
Discussion Following the Report of Prof. Langman....Pages 146-147
Mechanism of Injury to Gastric Mucosa by Non-Steroidal Anti-Inflammatory Drugs and the Protective Role of Prostaglandins....Pages 148-151
Discussion Following the Report of Prof. Cohen....Pages 152-152
Can Nonantisecretory Doses of Prostaglandins Prevent Mucosal Damage in Nonsteroidal Anti-inflammatory Drugs?....Pages 153-160
Clinical Aspects of the Protective Effects of Prostaglandins on Non-Steroidal Anti-Inflammatory Drug-Associated Mucosal Injury....Pages 161-167
Discussion Following the Report of Prof. Graham....Pages 168-169
Front Matter....Pages 171-171
Gastrointestinal Microbleeding and Ulcerogenic Drugs: Prevention by Co-Administration of Prostaglandins....Pages 173-177
Discussion Following the Report of Prof. Johansson....Pages 178-181
Exogenous Prostaglandins and Their Analogues in Gastric Ulcer Therapy....Pages 182-186
Exogenous Prostaglandins and their Analogues in Duodenal Ulcer Theraphy....Pages 187-197
Discussion Following the Reports of Prof. Rachmilewitz and Dr. Sontag....Pages 198-203
Front Matter....Pages 171-171
Clinical Safety of Antiulcer Prostaglandins: An Overview....Pages 204-209
Discussion Following the Report of Prof. Bianchi Porro....Pages 210-212
Ulcer Healing Drugs and Endogenous Prostaglandins: Carbenoxolone, Antacids, Sucralfate, Bismuth, and H 2 -Receptor Antagonists....Pages 213-222
Discussion Following the Report of Dr. Ruppin....Pages 223-226
Smoking and Ulcer Healing — Role for Prostaglandins?....Pages 227-232
Discussion Following the Report of Dr. Boyd....Pages 233-234
Ulcer Healing by Prostaglandins — Due to Decreased Acidity or Enhanced Mucosal Defense?....Pages 235-244
Discussion Following the Report of Prof. Dammann....Pages 245-245
Diarrheagenic Syndromes Sensitive to Prostaglandin Synthetase Inhibitors....Pages 246-250
Discussion Following the Report of Prof. Rask-Masden....Pages 251-253
Colitis and Non-Steroidal Anti-Inflammatory Drugs....Pages 254-259
Discussion Following the Report of Dr. Rampton....Pages 260-263
Therapeutic Role for Prostaglandins in Ulcerative Colitis?....Pages 264-267
Discussion Following the Report of Prof. Rachmilewitz....Pages 268-272
Inflammatory Bowel Disease: Treatment Modalities and Mucosal Prostaglandin/Leukotriene Formation....Pages 273-280
Discussion Following the Report of Prof. Sharon....Pages 281-283
Front Matter....Pages 285-285
The Natural History of Ulcer Disease and its Impact upon Therapeutic Options and Assessment of Drug Safety....Pages 287-290
Benefits and Risks of Long-term Medical Therapy with Histamine H 2 -receptor Antagonists in Ulcer Disease — A Physician’s View....Pages 291-295
Benefits and Risks of Long-term Medical Therapy with Histamine H 2 -Receptor Antagonists in Ulcer Disease: A Surgeon’s View....Pages 296-301
The Surgical Approach to Ulcer Disease and its Complications — Has there been a Change in the Last Decade?....Pages 302-309
Front Matter....Pages 285-285
The Efficacy of Prostaglandins in the Prevention of Stress Lesions in the Critically Ill Patient....Pages 310-315
Discussion Following this Section....Pages 316-319
Back Matter....Pages 321-332