دانلود کتاب Protein Engineering for Therapeutics, Part A

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Content:
Series Page
Page ii

Copyright
Page iv

Contributors
Pages ix-xii

Preface
Pages xiii-xiv
K. Dane Wittrup, Gregory L. Verdine

Volume in Series
Pages xv-xliv

Chapter 1 - Simplified Synthetic Antibody Libraries
Pages 3-23
Saravanan Rajan, Sachdev S. Sidhu

Chapter two - Generation of Dual-Variable-Domain Immunoglobulin Molecules for Dual-Specific Targeting
Pages 25-41
Jijie Gu, Tariq Ghayur

Chapter three - Discovery of Internalizing Antibodies to Tumor Antigens from Phage Libraries
Pages 43-66
Yu Zhou, James D. Marks

Chapter four - Optimizing Properties of Antireceptor Antibodies Using Kinetic Computational Models and Experiments
Pages 67-87
Brian D. Harms, Jeffrey D. Kearns, Stephen V. Su, Neeraj Kohli, Ulrik B. Nielsen, Birgit Schoeberl

Chapter five - Cell-Specific siRNA Delivery by Peptides and Antibodies
Pages 91-122
Sang-Kyung Lee, Alyssa Siefert, Jagadish Beloor, Tarek M. Fahmy, Priti Kumar

Chapter six - Conjugation of Anticancer Drugs Through Endogenous Monoclonal Antibody Cysteine Residues
Pages 123-138
Robert P. Lyon, David L. Meyer, Jocelyn R. Setter, Peter D. Senter

Chapter seven - Building and Characterizing Antibody-Targeted Lipidic Nanotherapeutics
Pages 139-166
Dmitri B. Kirpotin, Charles O. Noble, Mark E. Hayes, Zhaohua Huang, Tad Kornaga, Yu Zhou, Ulrik B. Nielsen, James D. Marks, Daryl C. Drummond

Chapter eight - Cell-Targeting Fusion Constructs Containing Recombinant Gelonin
Pages 167-214
Mi-Ae Lyu, Yu (Joshua) Cao, Khalid A. Mohamedali, Michael G. Rosenblum

Chapter nine - Fusions of Elastin-Like Polypeptides to Pharmaceutical Proteins
Pages 215-237
Wafa Hassouneh, Sarah R. MacEwan, Ashutosh Chilkoti

Chapter ten - Oral Enzyme Therapy for Celiac Sprue
Pages 241-271
Michael T. Bethune, Chaitan Khosla

Chapter eleven - Rational Design and Evaluation of Mammalian Ribonuclease Cytotoxins
Pages 273-290
Jo E. Lomax, Chelcie H. Eller, Ronald T. Raines

Chapter twelve - Engineering Reduced-Immunogenicity Enzymes for Amino Acid Depletion Therapy in Cancer
Pages 291-319
Jason R. Cantor, Vasiliki Panayiotou, Giulia Agnello, George Georgiou, Everett M. Stone

Author Index
Pages 321-337

Subject Index
Pages 339-344