توضیحاتی در مورد کتاب :
ضربانپذیری اکنون بهعنوان یک ویژگی عملکردی تقریباً همهجای سیستمهای عصبی غدد درونریز شناخته شده است. این جلد راهنمای جامعی برای فناوریهای تثبیت شده و نوظهور است که برای مطالعه پدیده گیجکننده ضربانپذیری مورد استفاده قرار میگیرد. رویکردهای مولکولی، سلولی، فیزیولوژیکی و ریاضی به تفصیل شرح داده شده است.
پروتکلهای جامع برای مطالعه روشهای
* در شرایط آزمایشگاهی برای مطالعه ضربانپذیری عصبی غدد درونریز
* نمونهبرداری در داخل بدن و روشهای ثبت برای پایش ضربان پذیری در چندین گونه
* بهبود روش های کمی و تحلیلی برای مطالعه ضربان پذیری هورمون
فهرست مطالب :
Content:
Methods in Neurosciences
Page ii
Front Matter
Page iii
Copyright page
Page iv
Contributors to Volume 20
Pages ix-xiii
Preface
Pages xv-xvi
JON E. LEVINE
Methods in Neurosciences
Pages xvii-xviii
1 - Analysis of Pulsatility in Immortalized GnRH Cell Lines
Pages 3-12
Gonzalo Martinez de la Escalera, Richard I. Weiner
2 - Use of Organotypic Cultures for the Study of Neuroendocrine Cells
Pages 13-44
Susan Wray
3 - Electrophysiological Analysis of Neuroendocrine Neuronal Activity in Hypothalamic Slices
Pages 47-67
Martin J. Kelly, Oline K. Rønnekleiv
4 - Calcium Signaling and Episodic Secretory Responses of GnRH Neurons
Pages 68-84
Stanko S. Stojilkovic, Lazar Z. Krsmanovic, Daniel J. Spergel, Melanija Tomic, Kevin J. Catt
5 - Patch-Clamp Studies on Identified Pituitary Gonadotropes in Vitro
Pages 85-99
Amy Tse, Bertil Hille
6 - Electrophysiological Analysis of GnRH Pulse Generator Activity in the Rhesus Monkey
Pages 100-113
Kevin T. O\'Byrne, Ernst Knobil
7 - In Vivo Electrophysiological Monitoring of the GnRH Pulse Generator in Rats and Goats
Pages 114-126
Masugi Nishihara, Yuji Mori, Mi-Jeong Yoo, Michio Takahashi
8 - In Vivo Sampling and Administration of Hormone Pulses in Rodents
Pages 129-161
Jon E. Levine, Andrew M. Wolfe, Tarja Porkka-Heiskanen, John M. Meredith, Jeffrey R. Norgle, Fred W. Turek
9 - Sampling of Hypophyseal Portal Blood of Conscious Sheep for Direct Monitoring of Hypothalamic Neurosecretory Substances
Pages 162-183
Alain Caraty, Alain Locatelli, Suzanne M. Moenter, Fred J. Karsch
10 - In Vivo Measurement of Pulsatile Release of Neuropeptides and Neurotransmitters in Rhesus Monkeys Using Push–Pull Perfusion
Pages 184-202
Ei Terasawa
11 - In Vitro Systems for Modeling Target Tissue Responses to Secretory Pulses of the Islet Hormones: Glucagon and Insulin
Pages 203-229
Charles J. Goodner
12 - Pulsatile Endocrine Secretion in the Ovine Fetus
Pages 230-246
Steven M. Yellon, Ede M. Apostolakis
13 - Pulsatile Corticosterone Secretion as Measured by Intraadrenal Microdialysis
Pages 247-264
Michael S. Jasper, Jill T. Walworth, William C. Engeland
14 - Comparative Analysis and Procedures for Validation of Pulse-Detection Algorithms
Pages 267-278
Randall J. Urban
15 - Deconvolution Analysis of Neuroendocrine Data: Waveform-Specific and Waveform-Independent Methods and Applications
Pages 279-325
Johannes D. Veldhuis, John Moorman, Michael L. Johnson
16 - Analysis of the Temporal Coincidence of Hormonal Pulses
Pages 326-335
George R. Merriam, Kenneth W. Wachter
17 - Assessing Temporal Coupling between Two or among Three or More Neuroendocrine Pulse Trains
Pages 336-376
Johannes D. Veldhuis, Michael L. Johnson, Lindsay M. Faunt, Eugene Seneta
18 - Estimating Thyrotropin Secretory Activity by a Deconvolution Procedure
Pages 377-390
Klaus Prank, Georg Brabant
19 - Modeling Modulatory Effects on Pulsatility
Pages 393-422
Jeppe Sturis, Erik Mosekilde, Eve Van Cauter
20 - Modeling Pulsatile Hormone Stimulation of Cell Responses
Pages 423-442
Rosalind P. Murray-Mclntosh, James Edward Alister McIntosh
21 - Pulsatile Neuropeptide Delivery and Analysis of Hormone Biosynthesis
Pages 445-465
Margaret A. Shupnik
22 - Use of an in Vitro Perifusion System to Study the Effects of Pulsatile Hormone Administration on the Control of the Hypothalamic–Pituitary–Ovarian Axis
Pages 466-487
Jacqueline F. Ackland, Kerry L. Knox, Adria A. Elskus, Patricia C. Fallest, Eve S. Hiatt, Neena B. Schwartz
23 - Pulsatile Administration of Insulin and Glucagon in Man
Pages 488-499
Pierre J. Lefèbvre, Giuseppe Paolisso, André J. Scheen
Index
Pages 501-510
توضیحاتی در مورد کتاب به زبان اصلی :
Pulsatility is now recognized as a nearly ubiquitous functional feature of neuroendocrine systems. This volume presents a comprehensive guide to the established and emerging technologies being used to study the perplexing phenomenon of pulsatility. Molecular, cellular, physiological, and mathematical approaches are described in detail.
Comprehensive protocols included for the study of
* In vitro methods for studying neuroendocrine pulsatility
* In vivo sampling and recording procedures for monitoring pulsatility in several species
* Improved quantitative and analytical methods for the study of hormone pulsatility