دانلود کتاب Retinoids: Advances in Basic Research and Therapy

فهرست مطالب :

Front Matter....Pages N1-XX
Introduction....Pages 1-2
Front Matter....Pages 3-3
From Vitamin A to Retinoids: Chemical and Pharmacological Aspects....Pages 5-11
Pharmacokinetics and Metabolism of Oral Aromatic Retinoids....Pages 13-20
In Vivo Immunostimulating Properties of Two Retinoids: Ro 10-9359 and Ro 13-6298....Pages 21-30
Vitamin A Transport and Delivery and the Mechanism of Vitamin A Toxicity....Pages 31-39
Experimental Toxicology of the Aromatic Retinoid Ro 10-9359 (Etretinate)....Pages 41-47
Studies in Reproductive Toxicology and Mutagenicity with Ro 10-9359....Pages 49-59
Cytogenetic Studies in Patients Treated with Oral Retinoid Ro 10-9359....Pages 61-65
Chromosomal Analysis in Patients Treated with the Aromatic Retinoid Ro 10-9359....Pages 67-70
Front Matter....Pages 71-71
Retinoids: New Developments in Their Mechanism of Action as Related to Control of Proliferative Diseases....Pages 73-76
The Effects of Retinoids on Stratum Corneum. Structure and Function....Pages 77-83
Light and Electron Microscopic Changes of Human Epidermis Under Oral Retinoid Treatment....Pages 85-92
Retinoid-Stimulated Material in Psoriatic Epidermis During Ro 10-9359 Therapy....Pages 93-98
Effects of Oral Retinoid on Dermal Components in Human and Animal Skin....Pages 99-108
Retinoid-binding Proteins and the Plasma Transport of Etretinate (Ro 10-9359) in Man....Pages 109-116
Biochemical Mechanism of Modulation of Skin Carcinogenesis by Retinoids....Pages 117-131
Mitogenic Properties of Aromatic Retinoids: in vivo and in vitro Effects on Epidermal Cells....Pages 133-138
On The Effects Induced by Aromatic Retinoid Ro 10-9359 on Explants of Skin from Psoriatic Patients....Pages 139-143
Effects of Retinoids on Keratinocytes in vitro....Pages 145-152
Influence of Retinoid on Human Blood Cells in vitro. TMMP-Retinoid Inhibits the Mitogenic Properties of Lectins and Modulates the Lymphocytic Response....Pages 153-160
Front Matter....Pages 71-71
Ro 10-9359 Retinoid Inhibits Both in vitro Epidermal Cell Proliferation and Differentiation....Pages 161-161
Front Matter....Pages 163-163
Aromatic Retinoids in Psoriasis: Clinical, Histological,Histochemical, Electron Microscopical and Immunological Investigations....Pages 165-173
Intermittent Dose Schedule of Retinoids (Ro 10-9359) for Long-term follow-up on Psoriasis (Preliminary Report)....Pages 175-183
Treatment of Severe Forms of Psoriasis with a Retinoic Acid Derivative: Ro 10-9359....Pages 185-191
Treatment of Psoriasis Vulgaris with a Low-dosage Ro 10-9359 (Tigason) Orally Combined with Corticosteroids Topically....Pages 193-199
Aromatic Retinoid (Ro 10-9359), RePUVA and PUVA in the Treatment of Psoriasis....Pages 201-203
Clinical Observations on Oral Retinoid Therapy of Psoriatic Arthropathy (Ro 10-9359)....Pages 205-209
Front Matter....Pages 211-211
Effect of Retinoids on the Sebaceous Glands of the Hamster Flank Organ....Pages 213-217
Effects of Two Retinoids in Animal Experiments and After Clinical Application in Acne Patients: 13-cis-Retinoic Acid Ro 4-3780 and Aromatic Retinoid Ro 10-9359....Pages 219-235
Oral Retinoids: Effects on Human Sebaceous Glands and Nodulocystic Acne....Pages 237-243
Oral Vitamin A (Retinol) in Acne Vulgaris....Pages 245-253
13-cis-Retinoic Acid in Acne (A Double-blind Study of Dose Response)....Pages 255-258
Effects of 13-cis-Retinoic Acid on Sebaceous Glands in Humans....Pages 259-266
A Clinical Trial of the Use of Tigason (Ro 10-9359) in Male Patients with Severe Acne Vulgaris....Pages 267-269
Front Matter....Pages 271-271
Treatment of Lichen Planus and Leukoplakia with the Oral Retinoid Ro 10-9359....Pages 273-278
Comparative Analysis of Two Retinoids in the Treatment of Disorders of Keratinization....Pages 279-286
Long-Term Follow-up of 30 Children Under Oral Retinoid Ro 10-9359....Pages 287-294
Treatment of Erythrokeratodermia Variabilis with Oral Retinoid (Ro 10-9359)....Pages 295-301
Ultrastructural Study of the Four Main Types of Ichthyosis After One Month’s Treatment with Ro 10-9359....Pages 303-306
Effect of Retinoids on Precancerous Lesions of Oral Mucosa....Pages 307-312
Front Matter....Pages 271-271
Treatment of Parapsoriasis en Plaques and Mycosis Fungoides with an Oral Aromatic Retinoid (Ro 10-9359)....Pages 313-316
Effects of Retinoid Ro 10-9359 Alone or in Combined Therapy in Several Skin Diseases — Clinical Observations and Biochemical Data....Pages 317-320
Effect of Systemic Ro 10-9359 Treatment on Immunological Parameters in Darier’s Disease....Pages 321-323
Freeze-Fracture Study of Psoriatic Lesions After Oral Administration of Retinoid....Pages 325-329
Psoriasiform Dermatitis in Patients with Skin Diseases Other than Psoriasis as Side Effect of Ro 10-9359....Pages 331-333
Immunological Features of Psoriasis: Effects of Ro 10-9359, Concanavalin A (ConA), Pokeweed Mitogen (PWM) and Methotrexate (MTX) on Cultivated Lymphocytes....Pages 335-338
Prevention of Psoriasiform Reactions After Beta-Receptor Blockers by Retinoid....Pages 339-340
Treatment of Psoriasis by Oral PUVA-Therapy Combined with Aromatic Retinoid (Re-PUVA)....Pages 341-345
Front Matter....Pages 347-347
The Posology of Oral Retinoids: How Much, How Often, How Long?....Pages 349-353
Long-term Biological Tolerance of Ro 10-9359....Pages 355-357
Some Hepatotoxic Side Effects Observed in Patients Treated with Aromatic Retinoid (Ro 10-9359)....Pages 359-362
Elevation of Serum Triglyceride Levels from Oral 13-cis-Retinoic Acid....Pages 363-369
A Proposal for Computing the Dosage of the Aromatic Retinoid Ro 10-9359 in Relation to Skin Surface....Pages 371-374
Ro 10-9359 in Psoriasis: Prospective Liver Biopsy Study of Potential Hepatotoxicity....Pages 375-382
Polarized Light Examination and Scanning Electron Microscopic Study of Hair, in Patients Treated with Aromatic Retinoids for a Long Time....Pages 383-384
Retinoid and Skin Cancer Prevention....Pages 385-388
Aromatic Retinoid and 13-cis-Retinoic Acid: Spermato-logical Investigations....Pages 389-395
Aromatic Retinoid in the Treatment of Multiple Superficial Basal Cell Carcinoma, Arsenic Keratosis and Kerato-Acanthoma....Pages 397-399
Ro 10-9359 in Epidermodysplasia Verruciformis. Preliminary Report....Pages 401-405
Oral Aromatic Retinoid (Ro 10-9359) Treatment of Two Patients Suffering with the Severe Form of Epidermodysplasia Verruciformis....Pages 407-410
Front Matter....Pages 347-347
Lack of Enhancement of Experimental Photocarcinogenesis by Retinoic Acid....Pages 411-415
Oral Treatment of Psoriasis with the Aromatic Retinoid Ro 10-9359....Pages 417-422
Treatment of Darier’s Disease with Systemic Ro 10-9359 (Tigason) — a Retinoic Acid Derivative....Pages 423-426
Thermography of Psoriasis. Effects of Retinoids....Pages 427-430
Front Matter....Pages 431-431
Results of Oral Retinoid Therapy in Different Forms of Psoriasis....Pages 433-434
Topical Aromatic Retinoid in the Treatment of Ichthyosis Vulgaris....Pages 435-437
Combined UVB Phototherapy and Low-dosage Oral Retinoid (Ro 10-9359) for Psoriasis Responding Inadequately to UVB Alone....Pages 439-442
Oral Retinoid Promotion of UV Light Action in Psoriasis. A Measure of UV Radiation Protection....Pages 443-445
Treatment of Epidermodysplasia Verruciformis or Multiple Verrucae Planae by Oral Aromatic Retinoid (Ro 10-9359 — Tigason)....Pages 446-446
The Influence of Topical and Oral Retinoid Treatment on Photocarcinogenicity in Hairless Albino Mice....Pages 447-451
Richner-Hanhart Syndrome (RHS) — Tyrosinemia Type II and Oral Aromatic Retinoid (Ro 10-9359). Report of two Cases....Pages 453-455
Light and Electron Microscopy Studies in Psoriasis Before and After Treatment with Retinoids (Ro 10-9359)....Pages 457-466
Electron Microscopic Characterization of the Mucus-like Material of the Epidermis Before and After Retinoid and Retinoid-PUVA (RePUVA) Treatment of Psoriasis....Pages 467-472
Long-term Effects of All-trans-retinoic Acid on Epidermal Glycosaminoglycan, Glycoprotein and Protein Synthesis in vitro....Pages 473-477
Clinical Aspects and Side Effects of Therapy by Oral Administration of Retinoids in Various Skin Diseases....Pages 479-481
Treatment of Severe Psoriasis by Ro 10-9359....Pages 483-485
Treatment of Psoriasis and Other Dermatoses with a New Aromatic Retinoid (Ro 10-9359)....Pages 487-492
Isoaccepting Serine t-RNAs Pattern as Marker of Epidermal Differentiation: its Alterations Under Retinoids....Pages 493-495
Influence of Retinoic Acid on Epidermal Wound Healing in Man....Pages 497-500
Ro 10-9359 and Pregnancy....Pages 501-501
Front Matter....Pages 431-431
Elevated Levels of Triglycerides in Patients with Skin Disease Treated with Oral Aromatic Retinoid. The Significance of Risk Factors....Pages 503-505
Front Matter....Pages 507-507
Biological Effects of Retinoids....Pages 509-514
The Use of Oral Aromatic Retinoids in Psoriasis Therapy: an Overview of Past, Present, and Future Developments....Pages 515-520
Closing Remarks on Acne....Pages 521-522
Back Matter....Pages 523-530