دانلود کتاب Sialic Acids and Sialoglycoconjugates in the Biology of Life, Health and Disease

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SIALIC ACIDS AND
SIALOGLYCOCONJUGATES
IN THE BIOLOGY OF LIFE,
HEALTH AND DISEASE
Copyright
Preface
Acknowledgments
Abbreviations
1
Sialic acid and biology of life: An introduction
Introduction
Occurrence and function
Functions of sialic acid
Structure diversity of sialic acids
O -acetylated sialic acid
Enzymes in O -acetylated sialic acid metabolism
Functions of O- acetylated sialic acids
N -acetylation of sialic acids
Other modifications of sialic acids
Sialic acid and the living world
Sialic acid and bacteria
Bacterial sialylation and host immune system
Archaea
Virus
Fungi
Plants
Invertebrates
Protozoa
Cnidarians
Helminths
Annedida
Arthropoda
Mollusca
Echinoderms
Vertebrates
Sialic acid-binding protein
Siglecs
Sialic acid-binding lectins
Selectins
Sialylation and disease
Tumor-associated carbohydrate antigens
Sialic acids and therapeutics: Where we stand
Therapeutic antibodies
Carbohydrate-based vaccines
Discussions
References
Further reading
2
Sialoglycans and genetically engineered plants
Introduction
N -glycosylation in plants
Sialylation and recombinant proteins produced in plants
Fc glycoengineering in plants
Applications
Mucin type O -glycans and plant expression
Introducing helminth glycosylation into plants
Detection
Discussion
References
Further reading
3
Sialic acid, sialoglycans, sialylation: A study in insects
Introduction
Insect physiology and development
Insects as vectors of human and animal diseases
N -Glycosylation: A comparison between mammals and insects
Sialic acids and insects
Sialylation in Drosophila
Sialylation and Spodoptera frugiperda (Sf9)
Sialylation and Ae. aegypti
Sialylation and silkworms
Ticks
Function of sialylation in insects
Genetic engineering approaches and sialylation
Discussion
References
Further reading
4
Sialoglycoconjugates and their role in physiology
Introduction
Nutrition
Reproduction
Ion channels
Nervous system
Stem cells
Cardiac function and disorders
Obesity
Complement
Dendritic cells
Others
Discussion
References
5
Pathogens, infectious disease biology and sialic acid
Introduction
Bacteria
Parasitic protozoa
Virus
Siglec sialic acid and infection biology
Prions
Discussion
References
Further reading
6
Sialic acids in autoimmune disorders
Introduction
Autoimmunity and tolerance
T cells
B cells
Sialic acid
Autoimmunity, tolerance, and sialic acid
Infectious pathogens, sialic acids, and autoimmune diseases
Immunoglobulins, sialic acids, and autoimmune diseases
Complements
Siglecs, HMGB-1, CD24, and autoimmunity
Neu5Gc and chronic inflammation
Selectins, sialic acids, and autoimmunity
Gangliosides and autoimmune diseases
Sialyltransferases and autoimmunity
Sialic acid, Glycobiotechnology, and application in autoimmune disorder therapy
Sialic acids and the therapeutic use of intravenous immunoglobulins
Discussions
References
Further reading
7
Lysosomal storage disease: Disorders related to glycans and sialic acid
Introduction
Lysosomes
Lysosomal storage diseases (LSD)
LSDs and defective glycan degradation
Defective glycoprotein degradation
Human α -mannosidosis
Human β -mannosidosis
Fucosidosis
α -N-Acetylgalactosaminidase deficiency: Schindler disease
Aspartylglucosaminuria
Defective glycolipid degradation
Fabry’s disease
Gaucher disease
Tay-Sachs disease
Defective synthesis and metabolism of gangliosides
Niemann-Pick C Disease
Krabbe disease
Multiple sulfatase deficiency (MSD)
Defective degradation of glucosaminoglycan (GAG)
MPS type IV disease or Morquio syndrome
The Sanfilippo syndrome, or MPS III
MPS I
MPS II or Hunter syndrome
MPS VI
MPS VII
MPS IX
Sialic acid-related disease
Salla disease
Free sialic acid storage disorders (FSASD)
Infantile sialic acid storage disorder (ISSD)
Sialidosis
Glycogen degradation defect diseases
Pompe’s disease
Other Glycogen storage disorders
Other LSDs
Cobalamin F-type disease
Cobalamin F-type disease
Danon’s disease (DD)
Treatment of LSDs
Discussions
References
8
Sialic acids and sialoglycoconjugates in cancer
Introduction
Sialic acid and serum sialylation as biomarkers in cancer
Gangliosides
Structure and synthesis
Gangliosides in tumors
Gangliosides and biotherapies
Sialic acid-Siglec axis and cancer
Sialyl Tn in cancer
Sialylransferase and cancer
Sialidase as cancer targets
Selectins
Discussion
References
Further reading
9
Sialic acids and sialoglycans in endocrinal disorders
Introduction
Sialylations and endocrines
Sialylations in endocrinal disorders
Ovary
Pancreas
Diabetes
Thyroid
Adrenal cancer
Pituitary cancer
Discussions
References
10
Sialic acid and xenotransplantation
Introduction
Xenotransplantation
Major problem associated with xenotransplantation and ways to circumvent them
Physiology
Rejection
Gal epitope
Complement
Thrombin
Glycosyltransferase transgenes
Acute humoral xenograft rejection
Cellular rejection
Infection
Sialic acid and xenotransplantation
Role of Neu5Gc
Role of α -gal antigen
Sialoadhesin
The Hanganutziu-Deicher (H-D) antigen
Xenograft acceptance and strategies based on sialylation
Animal xenotransplantation models and sialic acid
Strategies for knockouts
Sialylation related knockouts and health of donor animals
Discussion
References
Further reading
11
Nanotechnology and sialic acid biology
Introduction
Nanotechnology
Glyconanotechnology
Sialic acid and nanotechnology
Glycans and nanotechnology
Role of nanotechnology in detection and quantitation of sialic acid
Detection of gangliosides
Sialic acid in therapy
Nanotechnology bioimaging application, detection of cellular sialic acid expression and targeting
Discussion
References
Glossary
Index
A
B
C
D
E
F
G
H
I
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Z
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