دانلود کتاب Solvent Systems and Their Selection in Pharmaceutics and Biopharmaceutics

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Front Matter....Pages I-IX
Principles of Solubility....Pages 1-27
Ionic Equilibria and the pH Dependence of Solubility....Pages 29-51
Solvent Systems for Crystallization and Polymorph Selection....Pages 53-109
Solubility Issues in Early Discovery and HTS....Pages 111-136
Practical Aspects of Solubility Determination in Pharmaceutical Preformulation....Pages 137-149
Biorelevant Dissolution Media....Pages 151-177
Selection of Solvent Systems for Membrane-, Cell- and Tissue-Based Permeability Assessment....Pages 179-220
The Use of Solubilizing Excipients and Approaches to Generate Toxicology Vehicles for Contemporary Drug Pipelines....Pages 221-256
Solubilizing Vehicles for Oral Formulation Development....Pages 257-308
Solubilizing Systems for Parenteral Formulation Development—Small Molecules....Pages 309-339
Aqueous Solubilizing Systems for Parenteral Formulation Development—Proteins....Pages 341-357
Non-Aqueous Systems for Formulation Development—Proteins....Pages 359-402
Pharmaceutical Solvents as Vehicles for Topical Dosage Forms....Pages 403-426
Pharmaceutical Solvents for Pulmonary Drug Delivery....Pages 427-441
Back Matter....Pages 443-465