دانلود کتاب The Analytical Chemistry of Cannabis: Quality Assessment, Assurance, and Regulation of Medicinal Marijuana and Cannabinoid Preparations

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Front Cover......Page 1
The Analytical Chemistry of Cannabis......Page 4
Copyright Page......Page 5
Dedication......Page 6
Contents......Page 8
List of Contributors......Page 10
Foreword......Page 12
Preface......Page 14
Acknowledgments......Page 16
1 The Botany of Cannabis sativa L.......Page 18
Botanical Description......Page 19
Chemical Constituents and Phenotypes of C. sativa L.......Page 22
Cannabis Biosynthesis......Page 23
Selection of Elite Clones for Plant Propagation......Page 25
Propagation Through Seed......Page 26
Vegetative Propagation in Hydroponics......Page 28
In Vitro Plant Regeneration......Page 30
Quality Control of In Vitro Regenerated Plants......Page 31
Irrigation and Humidity......Page 32
Outdoor Cultivation......Page 33
Harvesting and Processing......Page 35
Conclusion......Page 36
References......Page 39
Phytocannabinoid Constituents in Cannabis......Page 44
Monoterpenoid, Sesquiterpenoid, and Diterpenoid Constituents of Cannabis......Page 48
Therapeutic Indications for Medicinal Cannabis and Cannabis-Derived Dosage Formulations......Page 49
Pharmacological Effects of Cannabis Constituents......Page 51
References......Page 54
Cannabis Inflorescence and Hashish......Page 60
Teas, Tinctures, Oils, and Extracts......Page 61
Consumables......Page 64
Formulations for Parenteral Administration......Page 67
Smoking and Vaporizing......Page 70
Bioavailability for Enteral and Transmucosal Administration......Page 72
Bioavailability for Other Parenteral Routes of Administration......Page 74
References......Page 76
4 Analytical Methods in Formulation Development and Manufacturing......Page 80
General Considerations in Sample Preparation for Analytical Characterization......Page 81
Direct Analysis of Cannabis Inflorescence and Its Extracts......Page 82
Separation and Analysis of Cannabis Using Gas Chromatography......Page 84
Broad-Spectrum Chemical Profiling......Page 85
Targeted Quantitative Analytical Approaches and Compendial Methods......Page 89
References......Page 95
Challenges in Quality Control and Safety of Cannabis and Cannabis-Derived Drugs......Page 100
Variability in Composition and Strength......Page 101
Content and Labeling Inaccuracies and Violations......Page 102
Foods and Pharmaceuticals......Page 103
Good Agricultural and Collection Practices......Page 104
Good Laboratory Practices......Page 105
Release Testing and Characterization of Chemical Delivery......Page 107
Stability Assessment......Page 108
Additional Considerations......Page 111
References......Page 114
From Herbal Medicines to Controlled Substances......Page 118
Implications to Consumers......Page 119
Implications to Suppliers......Page 120
Implications to Researchers......Page 121
Implications to Regulators......Page 124
References......Page 127
7 The Future of Cannabinoid Therapeutics......Page 128
References......Page 131
Back Cover......Page 133