فهرست مطالب :
Content:
Preface, Pages IX-X
Abbreviations, Pages XI-XII
1 - Introduction, Pages 2-6
2 - The Eukaryotic Protein Kinase Superfamily, Pages 7-47
3 - Cellular Functions of Protein Kinases, Pages 48-56
PKA: cAMP-dependent protein kinase (vertebrates), Pages 58-63
DmPKA: cAMP-dependent PK (D. melanogaster), Pages 64-66
ScPKA: cAMP-dependent PK (S. cerevisiae), Pages 67-69
DdPKA: cAMP-dependent PK (D. discoideum) (PkaC/PkaR, DdPK2/DdPK3), Pages 70-72
PKG: cGMP-dependent protein kinase (vertebrates), Pages 73-75
DmPKG: cGMP-dependent PK (D. melanogaster), Pages 77-79
PKC: Protein kinase C (vertebrates) (Ca2+-and phospholipid-dependent PK), Pages 80-88
DmPKC: Protein kinase C (D. melanogaster) (eye-PKC, DPKC53 (ey), inaC), Pages 89-90
CePKC: Protein kinase C (C. elegans) (TPA-1), Pages 91-92
ScPKC: Protein kinase C-1 (S. cerevisiae), Pages 93-94
RAC: RAC PK (vertebrates and D. melanogaster) (akt, PKB), Pages 95-97
βARK: β-Adrenergic receptor kinases (vertebrates), Pages 98-101
RhK: Rhodopsin kinase (vertebrates), Pages 102-104
Sch9: Sch9 protein kinase (S. cerevisiae), Pages 105-106
Ykr2: Ykr2 PK (S. cerevisiae), Page 107
Ypk1: Ypa1 (S. cerevisiae), Page 108
S6K: Ribosomal protein S6 kinase (vertebrates) p70S6 kinaseαI andαII (p70S6Kp85S6K), Pages 109-111
RSK: Ribosomal protein S6 kinase II (vertebrates) (Insulin-stiulated PK-1, ISPK1, MAP kinase-activated PK1), Pages 112-114
Dbf2/20: Dbf2 and Dbf20 PKs (S. cerevisiae), Pages 115-117
PvPK1: PvPK1 (Phaseolus vulgaris), Pages 118-119
OsG11A: G11A (Oryzae sativa), Pages 120-121
DMPK: Myotonic distrophy PK (vertebrates), Pages 122-123
Ddk2: Protein kinase 2 (D. discoideum), Pages 124-125
ScSpk1: Spk1 (S. cerevisiae), Pages 126-127
CaMKI: CaM-dependent protein kinase I (vertebrates), Pages 128-130
CaMKII: CaM-dependent PK II (vertebrates) (Type II CaM-dependent PK, multifunctional CaM- dependent PK, CaM-dependent multiprotein kinase), Pages 131-134
EF2K: Elongation factor-2 kinase (vertebrates) (CaM-dependent PK III), Pages 135-136
CaMKIV: CaM-dependent PK IV (vertebrates), Pages 137-139
DmCaMKII: Type II CaM-dependent PK (D. melanogaster) (Multifunctional CaM-dependent PK), Pages 140-142
ScCaMKII: CaM-dependent PK II (S. cerevisiae) (Cmk1/cmk2), Pages 143-145
PhK: Phosphorylase kinase (vertebrates), Pages 146-152
SkMLCK: Skeletal muscle myosin light chain kinase (vertebrates), Pages 153-156
SmMLCK: Smooth muscle myosin light chain kinase (vertebrates), Pages 157-160
Twn: Twitchin (C. elegans), Pages 161-165
DdMLCK: Myosin light chain kinase-A (D. discoideum), Pages 166-167
CDPK: Ca2+-dependent protein kinase (soybean) (Calmodulin-like domain protein kinase), Pages 168-170
AMPK: AMP-activated protein kinase (vertebrates) (HMG-CoA reductase kinase), Pages 171-173
Snf1: Snf1 protein kinase (S. cerevisiae) (CAT11, CCR12,3), Pages 174-175
Kin 1/2: Kin1 and Kin2 (S. cerevisiae), Pages 176-177
SpKin 1: Kin1 (S. pombe), Pages 178-179
Nim 1: Nim1 protein kinase (S. pombe) (Cdr1), Pages 180-181
pSnf1: Snf1-related protein kinses (Plantae) (Rkin1, Bkin 12, Akin10), Pages 182-183
Cdc2: Cdc2 protein kinase (vertebrates) (Maturation-promoting factor( MPF), M-phase kinase, growth-associated H1 kinase), Pages 184-187
Cdk2: cyclin-dependent kinase 2 (vertebrates), Pages 188-190
Cdk3: Cyclin-dependent kinase-3 (vertebrates), Page 191
Cdk4: Cyclin-dependent kinase-4 (vertebrates) (PSK-J3), Pages 192-193
Cdk5: Cyclin-dependent kinase 5 (vertebrates) (PSSALRE), Pages 194-195
Cdk6: Cyclin-dependent kinase-6 (vertebrates) (PLSTIIRE), Page 196
PCTAIRE: PCTAIRE-1,-2,-3 (vertebrates), Pages 197-198
Mo15: Mo15 (Xenopus laevis) (Cdk-activating kinase, CAK), Pages 199-200
DmCdc2: Cdc2 protein kinase (D. melanogaster), Pages 201-202
DmCdc2c: Cdc2 cognate (D. melanogaster), Pages 203-204
Cdc28: Cyclin-dependent PK (S. cerevisiae), Pages 205-207
Pho85: Pho85 protein kinase (S. cerevisiae), Pages 208-209
Kin28: Kin28 protein kinase (S. cerevisiae), Page 210
SpCdc2: Cdc2 protein kinase (S. pombe), Pages 211-213
Erk1/2: Extracellular signal-regulated kinases 1/2 (vertebrates) (MAP, MBP, EGF receptor T669 (Ert)), Pages 214-216
Erk3: Extracellular signal-regulated kinase 3 (vertebrates), Pages 217-218
DmErkA: Extracellular signal-regulated kinase (D. melanogaster), Pages 219-221
Kss1: Kinase suppressor of sst2-1 (S. cerevisiae) (Erk/MAP kinase homologue), Pages 222-224
Fus3: Fus3 protein kinase (S. cerevisiae), Pages 225-226
Mpk1: MAP kinase 1 (S. cerevisiae) (Slt2), Pages 227-228
Spk1: MAP kinase homologue (S. pombe), Pages 229-230
GSK3: Glycogen synthase kinase-3 (vertebrates) (Factor FA, ATP-citrate lyase kinase), Pages 231-233
Sgg: Shaggy protein kinase (D. melanogaster) (Zeste-white 3), Pages 234-237
Mck1: Meiosis and centromere regulatory PK (S. cerevisiae) (Ypk1), Pages 238-239
CK2: Casein kinase II (vertebrates), Pages 240-242
DmCK2: Casein kinase II (D. melanogaster), Pages 243-245
ScCK2: Casein kinase II (S. cerevisiae) (Cka1, Cka2), Pages 246-248
ZmCK2: Casein kinase II (Zea mays) (mCK-2α), Pages 249-251
Clk: Cdc28-like kinase (vertebrates) (Serine/threonine/tyrosine kinase, Sty), Pages 252-253
Yak1: Yak1 protein kinase (S. cerevisiae), Pages 254-255
Mak: Male germ cell-associated PK (vertebrates), Pages 256-257
Ched: Cholinesterase-related cell division controller (vertebrates), Pages 258-259
PITSLRE: PITSLRE protein kinase (vertebrates) (p58Gta, cdc2L1), Pages 260-265
KKIALRE: KKIALRE (vertebrates), Page 266
Sme1: PK essential for meiosis (S. cerevisiae) (Ime2), Pages 267-268
Sgv1: Suppressor of Gpa1val50 (S. cerevisiae), Pages 269-270
Snk: Serum-inducible kinase (vertebrates), Pages 271-272
Polo: Polo protein kinase (D. melanogaster), Pages 273-274
Mek: MAPK/Erk kinase (vertebrates) (MAP kinase kinase, MAPKK), Pages 275-277
Dsor1: MAP kinase kinase homologue (D. melanogaster), Pages 278-279
Ste7: ste7 protein kinase (S. cerevisiae), Pages 280-282
Pbs2: Pbs2 protein kinase (S. cerevisiae) (Hog4), Pages 283-284
Mkk1/2: MAP kinase kinase 1/2 (S. cerevisiae), Pages 285-286
Byr1: “Bypass of Ras1” protein kinase (S. pombe), Pages 287-288
Wis1: Wis 1 protein kinase (S. pombe), Pages 289-290
Ste11: Ste11 protein kinase (S. cerevisiae), Pages 291-292
Bck1: Bypass of C-kinase (S. cerevisiae) (Slk1, Ssp31), Pages 293-294
Byr2: Byr2 protein kinase (S. pombe), Pages 295-296
Nek1: NimA-related kinase (vertebrates), Pages 297-298
NimA: NimA protein kinase (Aspergillus nidulans), Pages 299-300
Fused: fused gene product (D. melanogaster), Pages 301-302
Kin3: Kin3 protein kinase (S. cerevisiae), Pages 303-304
Wee1: Wee1 protein kinase (vertebrates), Pages 305-306
SpWee1: Wee1 protein kinase (S. pombe), Pages 307-308
Mik1: Mik1 protein kinase (S. pombe), Pages 309-310
HRI: Haem-regulated eIF-2α kinase (vertebrates) (Haem-regulated inhibitor, haem-controlled repressor, HCR), Pages 311-313
PKR: Protein kinase (RNA dependent) (vertebrates) (dsRNA-activated PK, P1/eIF2 kinase, dsRNA-activated inhibitor (DAI), p68, p65), Pages 314-316
Tik: Protein kinase (RNA dependent) (vertebrates) (p65, dsRNA-dependent PK), Pages 317-318
Gen2: eIF2α protein kinase (S. cerevisiae), Pages 319-322
Raf1: Raf1 protein kinase (vertebrates), Pages 323-325
A-Raf: A-Raf protein kinase (vertebrates), Pages 326-327
B-Raf: B-Raf protein kinase (vertebrates), Pages 328-330
DmRaf: Raf homologue (D. melanogaster), Pages 331-332
CeRaf: LIN-45 Raf protein kinase (C. elegans), Pages 333-334
ActRII: Activin receptor types II/IIB (vertebrates), Pages 335-337
TGFβRII: TGF-β type II receptor (vertebrates), Pages 338-339
DAF-1: DAF-1 receptor PK (C. elegans), Pages 340-341
ZmPK1: ZmPK1 (Zea mays), Pages 342-343
Srk: S-locus receptor PK (Brassica spp.), Pages 344-346
CK1: Casein kinase 1 (vertebrates), Pages 347-349
Yck1/2: Casein kinase I homologues (S. cerevisiae) (YCK1/CKI2, YCK2/CKI1), Pages 350-352
Hrr25: Hrr25 protein kinase (S. cerevisiae), Pages 353-355
Pkn1: Pkn1 (Myxococcus xanthus), Pages 356-357
Mos: Mos gene product (vertebrates), Pages 358-360
Pim1: Pim 1 protein kinase (vertebrates), Pages 361-363
Cot: Cot on cogene product (vertebrates), Pages 364-365
Esk: Embryonal carcinoma S/T/Y kinase (vertebrates), Pages 366-367
Ttk: Threonine, tyrosine kinase (vertebrates), Pages 368-370
NinaC: NinaC gene product (D. melanogaster), Pages 371-373
SplA: Spore lysis A PK (D. discoideum) (Previously DPyk1), Pages 374-375
DPyk2: Protein tyrosine kinase 2 (D. discoideum), Pages 376-377
Cdc7: Cdc7 protein kinase (S. cerevisiae), Pages 378-379
Cdc15: Cell division cycle protein 15 (S. cerevisiae), Pages 380-382
Vps15: Vacuolar protein sorting PK (S. cerevisiae), Pages 383-385
Ran1: Ran1 protein kinase (S. pombe) (p52ran1, p52pat1), Pages 386-387
SHvU: US protein kinases (alphaherpesviruses) (HSV-PK, PRV-PK, US3 PK), Pages 388-390
LHvU: UL protein kinases (Herpesviruses) (HSV-1 UL13, 57K, VP18.8), Pages 391-393
B1R: B1R protein kinase (vaccinia virus), Pages 394-395
J9L: J9L PK (African swine fever virus), Page 396
Bcr: Bcr serine/threonine PK (vertebrates), Pages 397-399
BKDK: Branched-chainα-ketoacid dehydrogenase kinase (vertebrates) (Branched-chain 2-oxo acid dehydrogenase kinase, [3 methyl-2-oxobutanoate dehydrogenase (lipoamide)] kinase), Pages 400-401
PDK: Pyruvate dehydrogenase kinase (vertebrates), Pages 402-404
Src: c-Src protein-tyrosine kinase (vertebrates), Pages 58-61
Yes: Yes protein-tyrosin kinase (vertehrates) (p62c-ves), Pages 62-64
Fyn: Fyn protein-tyrosine kinase (vertebrates) (p59fyn), Pages 65-67
Fgr: Fgr protein-tyrosine kinase (vertebrates) (p59fgr), Pages 68-69
Lyn: Lyn protein-tyrosine kinase (vertebrates) (p53/56lyn), Pages 70-72
Hck: Hck protein-tyrosine kinase (vertebrates) (p59hck), Pages 73-75
Lck: Lck protein-tyrosine kinase (vertebrates) (p56lck), Pages 76-78
Blk: B lymphoid protein-tyrosine kinase (vetrerates), Pages 79-80
DmSrc: Src protein-tyrosine kinase (D. melanogaster) (Src 64B), Pages 81-82
Tec: Tec protein-tyrosine kinase (vertebrates), Pages 83-84
Emt: Expressed mainly in T cells (vertebrates) (Itk, Tsk), Pages 85-86
DmTec: Tec homologue (D. melanogaster) (DSrc28C, DSrc29A), Pages 87-88
Csk: C-terminal Src kinase (vertebrates), Pages 89-91
Fes/Fps: Fes/Fps protein-tyrosine kinase (vertebrates) (NCP92), Pages 92-94
Fer: Fes/Fps-related PTK (vertebrates) (ferT, flk, NCP94), Pages 95-96
DmFer: Fer protein-tyrosine kinase (D. melanogaster), Pages 97-98
Abl: c-Abl protein-tyrosine kinase (vertebrates), Pages 99-101
Arg: Abelson-related gene (vertebrates), Pages 102-103
DmAbl: Abelson PTK (D. melanogaster), Pages 104-106
CeAb1: Abl-related PTK (C. elegans), Pages 107-108
Syk: Spleen tyrosine kinase (vertebrates), Pages 109-111
Zap 70: Zap 70 protein-tyrosine kinase (vertebrates), Pages 112-113
Tyk2: Interferon-α regulated PTK (vertebrates) (p135tyk2), Pages 114-116
Jak1/2: Janus kinases 1 and 2 (vertebrates) (Just another kinase 1 and 2), Pages 117-119
Fak: Focal adhesion kinase (vertebrates) (FadK, pp125FAK), Pages 120-122
EGFR: EGF receptor (vertebrates) (c-erbB), Pages 123-125
ErbB2: EGF-receptor related PTK (vertebrates) (c-neu, HER2), Pages 126-128
ErbB3: EGF receptor-related PTK (vertebrates) (HER3), Pages 129-130
DER: EGF receptor homologue (D. melanogaster) (Faint little ball (flb), Ellipse (Elp), torpedo (top)), Pages 131-133
LET-23: LET-23 PTK (C. elegans), Pages 134-136
Eph: Kinase in erythropoietin-producing hepatoma (vertebrates), Pages 137-138
Eck: Epithelial cell kinase (vertebrates), Pages 139-141
Eek: Eph- and Elk-related PTK (vertebrates), Page 142
Hek: Human Eph/Elk like kinase (vertebrates) (Etk1), Pages 143-144
Elk: Elk receptor tyrosine kinase (vertebrates), Pages 145-146
Cek5: Chicken embryo kinase 5 (vertebrates), Pages 147-148
Axl: Axl protein-tyrosine kinase (vertebrates) [UFO (human, mouse), Ark (mouse)], Pages 149-151
Tie: Tie protein-tyrosine kinase (vertebrates), Pages 152-153
Tek: Tunica interna endothelial cell PTK (vertebrates), Pages 154-155
PDGFR: PDGF receptor (vertebrates), Pages 156-158
CSF1R: CSF-1 receptor (vertebrates) (Macrophage-CSF receptor1, c-fms gene product2), Pages 159-161
Kit: Steel factor receptor (vertebrates) (c-kit), Pages 162-164
Flt1: Fms-like PTK (vertebrates) (VEGF/VPF receptor), Pages 165-167
Flt4: Flt4 receptor PTK (vertebrates), Pages 168-169
FGFR1: FGF receptor-1 (vertebrates) (fms-like kinase, flk), Pages 170-172
FGFR2: FGF receptor-2 (vertebrates) (Bacterial expressed) kinase, bek, Keratinocyte growth factor receptor), Pages 173-175
FGFR3: FGF receptor-3 (vertebrates), Pages 176-178
FGFR4: FGF receptor-4 (vertebrates), Pages 179-181
DmFGFR1: FGF receptor-1 (D. melanogaster) (Breathless (btl)), Pages 182-183
DmFGFR2: FGF receptor-2 (D. melanogaster), Pages 184-185
InsR: Insulin receptor (vertebrates), Pages 186-189
IGF1R: IGF1 receptor (vertebrates) (Somatomedin receptor), Pages 190-192
IRR: InsR-related receptor (vertebrates), Pages 193-195
DmInsR: Insulin receptor homologue (D. melanogaster) (DIR, DILR, dIRH, Dir-a, Dir-b), Pages 196-198
Ltk: Leucocyte tyrosine kinase (vertebrates), Pages 199-200
Ros: c-Ros protein-tyrosine kinase (vertebrates), Pages 201-203
Sev: Sevenless receptor PTK (D. melanogaster), Pages 204-207
TrkA: Nerve growth factor receptor (vertebrates) (Trk, NTRK1), Pages 208-210
TrkB: BDNF receptor (vertebrates) (Neurotrophin-4 receptor, NTRK2), Pages 211-213
TrkC: Neurotrophin-3 receptor (vertebrates) (NTRK3), Pages 214-217
HGFR: HGF receptor (vertebrates) (c-MET proto-oncogene), Pages 218-220
Sea: Sea receptor PTK (vertebrates), Pages 221-222
Ret: Proto-oncogene activated by recombination (vertebrates), Pages 223-225
Klg: Kinase-like gene product (vertebrates), Pages 226-227
Torso: Torso PTK (D. melanogaster), Pages 228-229
DmTrk: TrK homologue (D. melanogaster) (gp160Dtrk), Pages 230-232
Index, Pages 405-418
توضیحاتی در مورد کتاب به زبان اصلی :
How do you keep track of basic information on the proteins you work with? Where do you find details of their physicochemical properties, amino acid sequences, gene organization? Are you tired of scanning review articles, primary papers and databases to locate that elusive fact?
The Academic Press FactsBook series will satisfy scientists and clinical researchers suffering from information overload. Each volume provides a catalogue of the essential properties of families of molecules. Gene organization, amino acid sequences, physicochemical properties, and biological activity are presented using a common, easy to follow format. Taken together they compile everything you wanted to know about proteins but were too busy to look for.
The Protein Kinase FactsBook: Protein - Tyrosine Kinases contains over 65 entries on members of the family from vertebrates, Drosophila, slime moulds and other organisms.
Key Features
* Entries provide information on:
* Subunit structure and isoforms
* Genetics
* Sequence database accession numbers
* Domain structures
* Amino acid sequences
* Homologues in other species
* Patterns of expression
* Physiological substrates and specificity determinants
* Assays
* Enzyme activators and inhibitors
* References