دانلود کتاب The Roots of Modern Biochemistry: Fritz Lippmann's Squiggle and its Consequences

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1 Fritz Lipmann 1899–1986\nLife with Fritz\nA Long Life in Times of Great Upheaval\nFritz Lipmann: In Memoriam\nLipmann’s Remarkably Fulfilled Life as a Researcher\nFritz Lipmann: June 12, 1899–July 24, 1986\nFritz Lipmann Molding the Design of Molecular Bioenergetics\nRecollections of Fritz Lipmann, 1941–1945\nIn Celebration of the Scientific Genius of Fritz Lipmann\nLipmann and “Not Strictly Biochemistry”\nCommunication in Metabolic Control. Intuition and Method in Biochemistry: Four Years each with Krebs and Lipmann\nFritz Lipmann: Squiggle to Protein Sulfation\nFritz Lipmann (1899–1986), Honorary Member of the Leopoldina Academy\nDahlem in the Late Nineteen Twenties\nOur Apprenticeship\nThe Kaiser-Wilhelm-Institutes in Berlin-Dahlem in the Late 1930ies and Early 1940ies: Reminiscences of a Student of Biochemistry\nOn the Origin of the Squiggle (~)\n2 Biochemistry Comes of Age\nThe History of Metabolites Isolated from Urine\nThe Pentose Phosphate Pathway\nGlycolysis and the Dawn of Modern Biochemistry\nEnergy-Rich Bonds and Enzymatic Peptide Synthesis\nA Nostalgic View of the TCA Cycle in Bacteria\nThe Role of Vitamins and their Carrier Proteins in Citrate Fermentation\nLipmann’s Influence on Firefly Luminescence\nSulfur in Biomimetic Peptide Syntheses\nThe Function of Teichoic Acids in Walls and Membranes of Bacteria\nThe Amidotransferases: Origins of the Concept of Affinity Labeling of Enzymes\nIntracellular Protein Degradation: Past, Present and Future\nLipmann’s Squiggle and the Unification of Cellular Structure and Function\nThe Historical Intermingling of Biochemistry and Cell Biology\nRegulation of Function of Membrane Proteins by Phosphorylation and Dephosphorylation\nMolecular Biology of Brain Peptides and their Cognate Receptors\nThe Biological Activity of Tuftsin, Thr-Lys-Pro-Arg\nBiosynthesis of Linear Gramicidin, Pentadeca Peptide, is Tight Linked to Serine Metabolism and to Membranous Phosphoglyceride\nFrom Phosphoenolpyruvate Carboxykinase to Sporulation: Personal Reflections on Dr. F. Lipmann\nResearch on Nonribosomal Systems: Biosynthesis of Peptide Antibiotics\nMetabolism of Carnosine and Related Peptides\n3 Molecular Biology Sharpens its Tools\nDNA Repair in Human Cells: Molecular Cloning of cDNAs Coding for Enzymes Related to Repair\nAcyl~ Phosphate Intermediates in Oxidative DNA Sugar Damage by Antibiotics\nRts1: A Multiphenotypic, Unusual Temperature Sensitive Drug Resistance Factor\nHuman Prostatic Growth Factor on Steroid Hormones in Stimulating Thymidine Incorporation into DNA\nDevelopmentally Regulated Gene Amplification in Rhynchosciara\nFritz Lipmann, a Few Personal Memories, and: What Else Came Out of the High-Energy Phosphate Bond?\nRegulation of Gene Expression by Posttranslational Modification of Transcription Factors\nHow Does the Arginine Repressor Regulate the Synthesis of Arginine Biosynthetic Enzymes?\nThe Biochemistry and Molecular Biology of the Terminal Reactions of Methionine Biosynthesis in Escherichia coli\nThe Wheat Embryo, Then and Now\nMechanism of Cytotoxic Action and Structures of Thiadiazolo-pyrimidines\nArchitecture of Ribosomal Particles as Investigated by Image Reconstruction and X-Ray Crystallographic Studies\nInitiation of Protein Synthesis: Early Participation and Recent Revisit\nStructure of Ribosomal RNA Genes of Eukaryotes: Some Solved and Unsolved Questions\nEnergetics and Dynamics of the Protein-Synthesizing Machinery\nExpression\nPunctuation in the Genetic Code: A Plausible Basis for the Degeneracy of the Code to Initiate Translation\nReconstruction of Translation: Role of EF-P in Regulation of Peptide Bond Formation\nOn the Role of Spermine in Protein Synthesis\n4 Functional Dynamics\n4.1 The Squiggle-Symbol of Bioenergetics\nEnergy-Rich Compounds and Work\nSquiggle Phosphate of Inorganic Pyrophosphate and Polyphosphates\nEnzymology of 3ʹ-Squiggled Nucleotides\nPyridine Nucleotides as Group Transfering Coenzymes\nThe Nature of Squiggle in Oxidative Phosphorylation\nMotional Dynamics of Fatty Acids: Advantages of 15N and Deuterium Substituted Fatty Acid Spin Labels for Studies of Lipid-Protein Interactions and Motion in Membrane Bilayers\nThyroid Hormones and Oxidative Phosphorylation\nStructure-Activity Relationships of Natural and Synthetic. E-β-Methoxyacrylates of the Strobilurin and Oudemansin Series\nThe Intracellular Mechanism of Insulin Action\nUnity and Diversity in Biological Redox Catalysis: Comparative Enzymology of Some Microbial Oxidoreductases Showing Variation in Cofactor Identity\nAmmonia-Forming, Dissimilatory Nitrite Reductases as a Homologous Group of Hexaheme C-Type Cytochromes in Metabolically Diverse Bacteria\nHalorhodopsin\nControl of Futile Transmembrane Potassium Cycling in Escherichia coli\nBioenergetics of Protein Transport into Mitochondria: Role of Δψ and of Nucleoside Triphosphates\nSome Recent Functional and Structural Contributions to the Molecular Mechanism of Photosynthesis\nSalt Toxicity and Mineral Deficiency in Plants: Cytoplasmic Ion Homeostasis, a Necessity for Growth and Survival Under Stress\n4.2 Molecular Recognition and Communication\nDawn of Ca Research: Regulation of Muscle Contraction\nComparative Aspects of the Mechanisms of Energy Transduction in Sarcoplasmic Reticulum Between Rabbit and Frog Skeletal Muscle\nCaltrin: A Versatile Regulator of Calcium Transport in Spermatozoa\nProtein Kinase C, the Structural Heterogeneity and Differential Expression in Rat Brain\nRegulation of Erythrocyte Membrane Cytoskeletal Protein Interactions by Phosphorylation\nA Kinase Splitting Membranal Proteinase: Use in the Study of Receptors Involved in the Cellular Response to Hormones\nFritz Lipmann, Phosphoproteins and Regulation of Aromatic Amino Acid Hydroxylase Activity\nThe Regulation of Hepatic Phenylalanine Hydroxylase by Phosphorylation-Dephosphorylation\nCatabolite Inactivation and Adenylate Cyclase in Yeast\nProtein Modification by Tyrosine-Sulfation: Possible Functional Implications\nProteoglycans and Connective Tissue Pathobiochemistry\nAcylation of Myelin Proteolipid Protein: A Link to the Past\nThe Unusual Regulation of the Adenylyl Cyclase of Amphibian Oocytes by Progesterone. – A Review\nSterol Synergism, A Tool for Studies on Sterol Function\nChemical Modification of Benzodiazepine Receptors of Cortical P2 Membranes\nDual Pathways for the Catabolism of γ-Hydroxy-butyrate: Cytosolic and Mitochondrial Mechanisms\n5 Evolution\nPrebiotic Syntheses and the Mechanism of Early Chemical Evolution\nPrebiotic Roots of Informed Protein Synthesis: Nature of the Lipmann Connection\nA Case for an Additional RNA Base Pair in Early Evolution\nInorganic Pyrophosphate in Cellular Energetics and Evolution\nSelforganization in Biosystems\nList of Contributors\nAcknowledgements\nLipmann’s Coworkers at Massachusetts General Hospital, Boston, and the Rockefeller University, New York\nBibliography 1924–1985\nIndex