دانلود کتاب Translational Stroke Research: From Target Selection to Clinical Trials

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Front Matter....Pages i-xxiv
Front Matter....Pages 1-1
Vascular Targets for Ischemic Stroke Treatment....Pages 3-36
Identifying Vascular Targets to Treat Hemorrhagic Stroke....Pages 37-55
Experimental Platforms for Assessing White Matter Pathophysiology in Stroke....Pages 57-78
Neuroprotection in Stroke....Pages 79-97
Front Matter....Pages 99-99
Protein Aggregation and Multiple Organelle Damage After Brain Ischemia....Pages 101-116
Antioxidants and Stroke: Success and Pitfalls....Pages 117-143
Caspase-Independent Stroke Targets....Pages 145-174
Hypoxia-Inducible Factor: A New Hope to Counteract Stroke....Pages 175-188
Thrombin in Ischemic Stroke Targeting....Pages 189-204
Toll-Like Receptor Agonists as Antecedent Therapy for Ischemic Brain Injury: Advancing Preclinical Studies to the Nonhuman Primate....Pages 205-230
Angiogenesis and Arteriogenesis as Stroke Targets....Pages 231-249
Hematopoietic Growth Factor Family for Stroke Drug Development....Pages 251-276
Soluble Epoxide Hydrolase as a Stroke Target....Pages 277-294
Membrane Potential as Stroke Target....Pages 295-303
Hypothermia to Identify Therapeutic Targets for Stroke Treatment....Pages 305-320
Stroke Preconditioning to Identify Endogenous Protective or Regenerative Mechanisms....Pages 321-334
microRNAs in Ischemic Brain: The Fine-Tuning Specialists and Novel Therapeutic Targets....Pages 335-352
Neuroglobin: A Novel Target for Endogenous Neuroprotection....Pages 353-372
Characterization of Novel Neuroprotective Lipid Analogues for the Treatment of Stroke....Pages 373-385
Na + /H + Exchangers as Therapeutic Targets for Cerebral Ischemia....Pages 387-401
Front Matter....Pages 99-99
Iron as a Therapeutic Target in Intracerebral Hemorrhage: Preclinical Testing of Deferoxamine....Pages 403-416
Potential Therapeutic Targets for Cerebral Resuscitation After Global Ischemia....Pages 417-450
The Splenic Response to Ischemic Stroke: Neuroinflammation, Immune Cell Migration, and Experimental Approaches to Defining Cellular Mechanisms....Pages 451-468
Front Matter....Pages 469-469
Overcoming Barriers to Translation from Experimental Stroke Models....Pages 471-492
Animal Models of Stroke for Preclinical Drug Development: A Comparative Study of Flavonols for Cytoprotection....Pages 493-524
Clinical Relevance in a Translational Rodent Model of Acute Ischemic Stroke: Incorporating the Biological Variability of Spontaneous Recanalization....Pages 525-540
A Clinically Relevant Rabbit Embolic Stroke Model for Acute Ischemic Stroke Therapy Development: Mechanisms and Targets....Pages 541-584
Animal Models of Intracranial Aneurysms....Pages 585-593
Animal Models of SAH and Their Translation to Clinical SAH....Pages 595-613
Front Matter....Pages 615-615
ADME (Absorption, Distribution, Metabolism, Excretion): The Real Meaning—Avoiding Disaster and Maintaining Efficacy for Preclinical Candidates....Pages 617-638
CeeTox Analysis to De-risk Drug Development: The Three Antioxidants (NXY-059, Radicut, and STAZN)....Pages 639-656
Front Matter....Pages 657-657
Site-Specific, Sustained-Release Drug Delivery for Subarachnoid Hemorrhage....Pages 659-680
Therapeutic Potential of Intranasal Delivery of Drugs and Cells for Stroke and Other Neurological Diseases....Pages 681-688
Front Matter....Pages 689-689
High-Dose Albumin for Neuroprotection in Acute Ischemic Stroke: From Basic Investigations to Multicenter Clinical Trial....Pages 691-719
The Translation Procedure of Low-Level Laser Therapy in Acute Ischemic Stroke: A Nonpharmaceutics Noninvasive Method....Pages 721-743
Use of Microbubbles in Acute Stroke....Pages 745-752
Transcranial High-Intensity Focused Ultrasound for Sonothrombolysis in Stroke....Pages 753-776
Cellular Therapy for Ischemic Stroke....Pages 777-814
Front Matter....Pages 815-815
Repair-Based Therapies After Stroke....Pages 817-831
A Critical Review of Stroke Trial Analytical Methodology: Outcome Measures, Study Design, and Correction for Imbalances....Pages 833-861
Front Matter....Pages 815-815
Metabolic Imaging in Translational Stroke Research....Pages 863-879
Computational Analysis: A Bridge to Translational Stroke Treatment....Pages 881-909
Innovations in Stroke Clinical Trial Design....Pages 911-916
Back Matter....Pages 917-923