دانلود کتاب Vitamin D: A Pluripotent Steroid Hormone: Structural Studies, Molecular Endocrinology and Clinical Applications. Proceedings of the Ninth Workshop on Vitamin D, Orlando, Florida, USA, May 28–June 2, 1994

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FOREWORD\nOfficial Sponsors and Donors\nYOUNG INVESTIGATOR AWARDEES NINTH WORKSHOP ON VITAMIN D\nVitamin D Workshop. Career Recognition Awardees\nContents\nChemistry of Vitamin D\nShape and Conformation of Vitamin D. 11-Fluoro-1a-Hydroxyvitamin D₃: The Quest for Experimental Evidence of the Folded Vitamin D Conformation\nConformation and Related Topological Features of Vitamin D: Structure-Function Relationships\nChemical Conversion of Vitamin D₃ to Calcitriol Lactone\nDesign, Synthesis, and SAR of Some 1-Substituted A-Ring Analogs of Calcitriol\nA General Synthetic Route to A-Ring Hydroxylated Vitamin D Analogs from D-Pentoses\nRetiferols. Design and Synthesis of the New Class of Vitamin D Analogs\nIntroduction of 1a-Hydroxyl Group to Provitamin D Causes New Photoisomerization Reactions\nSynthesis and Determination of the Configurations of the 23-Hydroxylated Metabolites of Calcipotriol (MC 903) and their Epimers\nSyntheses of Potential Inhibitors of 25-Hydroxyvitamin D₃-1a-Hydroxylase: A-Ring Analogs\nMetallic Complexes of Hydroxylated Derivatives of Vitamin D₃\nA New Route to the Lythgoe-Roche\'s A-Ring Precursor of 1a,25-Dihydroxyvitamin D₃\nStructure-Activity Studies of Fluorinated Vitamin D Analogs\nAn In Vitro Model of Previtamin D Photosynthesis as Possible Monitor of Ozone Depletion\nSynthesis of 24-Hydroxy-Vitamin D Analogues\nChromatographic Isolation and Spectroscopic Characterization of the Photoisomers of 1a,25-Dihydroxy-Provitamin D₃\nA New Route to the Vitamin D Triene System\nStudies on the Synthesis of 19-Norprevitamin D₃ Analogues\nStructure/Function Studies of Vitamin D Steroids\nThe Need for New Vitamin D Analogues: Mechanisms of Action and Clinical Applications\nFuture Prospects for Vitamin D Analogs\nChemistry and Biology of 22,23-yne Analogs of Calcitriol\nChemistry and Biology of 23-oxa-aro- and 23-thia-aro-Vitamin D Analogues with High Antiproliferative and Low Calcemic Activity\nActivity of Vitamin D Analogs in Co-Transfected COS-7 Cells\nSynthesis and Biological Character of 1β-Hydroxylated Vitamin D₃ Analogs\nBiological Activity and Conformational Analysis of 1β,25-Dihydroxyvitamin D₃ and its Analogues\nTopological Mimics of the 6-s-cis-Conformer of 1a,25-Dihydroxyvitamin D₃ Based on the Provitamin D Skeleton\nChemistry and Biology of Highly Active 22-oxy Analogs of 20-epi Calcitriol with Very Low Binding Affinity to the Vitamin D Recepto\nNew Discoveries in Vitamin D Related Compounds\nModelling of Previtamin D Photosynthesis in View of its Conformational Flexibility\nActive Vitamin D Analogs with Side Chain Hydroxyl Group Occupying Diverse Spatial Region\nSynthesis and Biological Activity of 23-oxa Vitamin D Analogues\nSynthesis and Biological Activity of 20-Hydroxylated Vitamin D Analogues\n20-Methyl Vitamin D Analogues\n2β-Substituted Calcitriols and Other A-Ring Substituted Analogues - Synthesis and Biological Results\nSyntheses and Biological Activity of 1ß-Substituted Active Vitamin D₃ Analogs\nVitamin D Binding Protein\nProbing the Vitamin D-Sterol Binding Domain of Human Vitamin D-Binding Protein: Chemical Modification of Specific Amino Acid Residues\nCrystallization and Preliminary X-Ray Investigation of Vitamin D-Binding Protein from Human Serum\nEffects of Vitamin D-Binding Proteins on Biological Functions of 1 a,25-Dihydroxyvitamin D₃ Analogues\nVitamin D Hydroxylases: Biochemistry and Regulation\nDifferences of the Regulation of 24-Hydroxylase Gene Expression in the Kidney and Intestine\nRegulation of the Ferredoxin Component of Renal Hydroxylases at the Transcriptional and Postradiational Level and of the Protein Inhibitor of Cyclic AMP-Dependent Kinase\nSite and Rate of Hydroxylation of 1a-OH-D₃ Analogs by CYP27 Not Altered by Increasing Length or Changing Orientation of Vitamin D₃ Side Chain\nProtein Kinase C Up-Regulates 1 a,25-Dihydroxyvitamin D₃-Induced Expression of 24-Hydroxylase Gene\nIGF-I Restores the Age-Related Defect in Renal 1,25(OH)₂D₃ Biosynthesis in Response to Dietary Phosphorus Restriction in Rats\nIn Vitro Production of 1,25-Dihydroxyvitamin D₃ by Cultured Mouse Kidney Cells and its Regulation by Extracellular Phosphate and IGF-1\nThe Cytochromes P450 Catalyzing 25-Hydroxylation of Vitamin D and la-Hydroxy lation of 25-Hydroxyvitamin D₃ in Pig Liver\nEvidence that 1a - and 27-Hydroxylation of 25-Hydroxyvitamin D₃ are Catalyzed by CYP27 in Pig Kidney Mitochondria\nThe Kinetics of Monocyte la-Hydroxy läse in Uremia. Modulation by Calcitriol and 25(OH)D₃ Therapy\nEicosanoid Inhibitor and Cytokine Regulation of 1,25(OH)₂D₃ Synthesis in Synovial Fluid Macrophages from Patients with Inflammatory Arthritis\n25-Hydroxyvitamin D-la-Hydroxy läse is Responsible for the Synthesis of 1.25-Dihydroxyvitamin D₃ by Peritoneal Macrophages of CAPD Treated Uremic Patients\nInfluence of Extracellular Calcium in the Kinetic Behaviour of 1-Hydroxylase (1-OHase) and 24-Hydroxylase (24-OHase) in Walker Carcinosarcoma 256 Cells (WS) and in the Renal Proximal Tube Phenotype Cells (LLC-PK1)\nInsulin and Calcitonin Decrease the Expression of the Renal 25(OH)D-24- Hydroxylase Cytochrome P450 in Diabetic Rats\nContinuous Activation of 25-Hydroxyvitamin D₃-24-Hydroxylase mRNA Expression by 1a,25-Dihydroxyvitamin D₃-3ß-Bromoacetate\nRegulation of 24-Hydroxylase mRNA Expression by 1a,25(OH)₂D₃ and its Fluorinated Analogues\nComparative Effects of 1,25-Dihydroxyvitamin D₃ and EB 1089 on Murine 25-Hydroxyvitamin D₃-24-Hydroxylase\nVitamin D Metabolism and Catabolism\nTarget Cell Metabolism of Vitamin D and its Analogs\nIn Vivo Regulation of Rat Intestinal 24-Hydroxylase (I-24-OHase): Potential New Role of Calcitonin\nMetabolism of 1a,25-Dihydroxyvitamin D₃ and One of its A-Ring Diastereomer 1a,25-Dihydroxy-3-Epivitamin D₃ in Neonatal Human Keratinocytes\nVitamin D Metabolism in Human Colon Adenocarcinoma-Derived Caco-2 Cells\nStudies on Vitamin D Metabolism by a Human Small Cell Lung Cancer (SCLC) Cell Line, NCI-H82\nThe In Vitro Metabolism of Calcipotriol, 1,24(OH)₂D₃ and 1,25(OH)₂D₃\nRegulation of Tissue Inhibitor of Metalloproteinases (TIMP) by 1,25- and 24,25- Dihydroxyvitamin D₃ in the Rat Growth Plate\nThe Effect of Parathyroid Hormone on Renal 24-Hydroxylase Activity in the Isolated Perfused Rat Kidney\nSteroidal Hormones as Modulators of Vitamin D Metabolism in Human Keratinocytes\nPotentialisation of Vitamin D (Analogs) by Cytochrome P-450 Enzyme Inhibitors is Analog- and Cell-type Specific\nNovel Cleavage of Vitamin D₂ Side Chain During Catabolism by Keratinocyte Cell Line\n22-Oxacalcitriol is Metabolized to C₂₁ Side-Chain-Cleaved Products in Both Liver and Target Cells\nMetabolism of the 1a,25(OH)₂D₃ Analog 1a,25(OH)₂-16-ene-23-yne-D₃ in BALB/c Leukemic Mice and WEHI-3 Myeloid Leukemia Cells\nMicrotubules Mediate Cellular 25(OH)D₃ Traffic and the Response to 1,25(OH)₂D₃ in Human Monocytes\nStudy of the Metabolism of 1,25-Dihydroxy-16-ene-Vitamin D₃ in Rat Kidney Using On-line HPLC-Electrospray Tandem Mass Spectrometry\nHuman Placental Explants: An Efficient In Vitro Model for Comparative Metabolism of 1,25(OH)₂D₃ and its Synthetic Analogs\n24,25(OH)₂D₃ Modulates 1,25(OH)₂D₃ Metabolism in Human Osteoblasts\nMetabolism of 25 Hydroxy Vitamin D₃: Kinetics of 23 and 24 Hydroxylases in Human Term Placenta\nComparative Study in Vitamin D Metabolism from the View-Point of Ontogeny and Phylogeny\nReceptors for 1a,25(OH)₂D₃\nReceptor Mediated Genomic Actions of 1,25(OH)₂D₃: Modulation by Phosphorylation\nModulation of Vitamin D₃ Target Gene Selectivity by Receptor Dimerization\nThe Molecular Basis for the Genomic Actions of the Vitamin D₃ Hormone\nExpression of RXRa in Human Leukemic Cells During Differentiation Induced by All-Trans Retinoic Acid and 1a,25-Dihydroxyvitamin D\nDifferential Activation of the Vitamin D Receptor (VDR) by 1,25(OH)2- Vitamin D₃ and its 20-Epimers\nDopamine Activates Vitamin D Receptor But Not Retinoid Receptor Mediated Transcription\nOrdered Binding of Human Vitamin D and Retinoid-X Receptor Complexes to Asymmetric Vitamin D-Responsive Elements\nImmunohistochemical Localization of 1,25-Dihydroxy vitamin D₃ [1,25(OH)₂D₃] Receptors (VDR) in Human and Rat Pancreas\nStructure-Function Relationship of Human Parathyroid Hormone on Vitamin D Receptor Regulation in Osteoblast-Like Cells (ROS 17/2.8)\nInsulin-Like Growth Factor I Up-Regulates Intestinal 1,25(OH)₂D₃ Receptor in Phosphorus Restricted Rats\nA Peptide C-Terminal to the Second Zn-Finger of Human Vitamin D Receptor is Able to Specify Nuclear Localization\nMolecular Cloning and Sequencing of a Novel cDNA Related to the Steroid/Thyroid/Vitamin Family of Nuclear Receptors from a Vitamin DDeficient Chick Intestinal cDNA Library\nIsolation and Analysis of cDNA Encoding a Naturally-Occurring Truncated Form of the Human Vitamin D Receptor\nEB 1089, a Vitamin D Analogue, Induces the Vitamin D Receptor to Form Selective Receptor Complexes Depending on Cell Type\nGene Regulation\n1,25(OH)₂D₃ Response Elements: Is There an Order?\nVitamin D Regulation of Osteocalcin Gene Transcription: A Model for Defining Molecular Mechanisms of 1,25(OH)₂D₃ Control of Osteoblast Growth and Differentiation\nRegulation of Integrin Expression by 1,25 Dihydroxyvitamin D₃\nIdentification of a Chicken Intestinal DNA Binding Activity Not Related to the Vitamin D Receptor, but Capable of Specific Binding to Vitamin D Response Elements\nTranscriptional Regulation of the Avian Mitochondrial Genome by Altered Dietary Vitamin D₃ Status: A Comparison of Intestinal and Kidney Responses\nA Novel Vitamin D Response Element in the Murine c-fos Promoter\n1,25(OH)₂-Vitamin D3 (D3) Interactions with 3,5,3\'-Triiodothyronine (T3) Signaling in 3 Osteosarcoma Cell Lines\n1,25(OH)₂-Vitamin D₃ (D₃) Signaling in HT-29 Cells: Interactions with 9-eis Retinoic Acid (9-eis RA)\nProtein Inhibitor of Cyclic AMP-Dependent Protein Kinase: Genomic Cloning of a 1,25(OH)₂D₃ Down-Regulated Protein\nLack of 9-eis Retinoic Acid Effect on Renal 24-Hydroxylase mRNA Expression by 1,25-Dihydroxyvitamin D₃ In Vivo\nRegulation of Osteopontin Expression by Calcitriol in Mouse Epidermal JB6 Cells\nDissociation between Regulation of Growth and C-myc Oncogen Expression by Vitamin D in Caco-2 Cells\nTGF-ßl Inhibits the Induction of Osteocalcin Gene by 1,25(OH)₂D₃ at the Level of Transcription\nMechanism of Action of 1,25-Dihydroxyvitamin D Differs in Kidney, Intestine, and Bone Cell Lines\nmRNA Levels of the Inhibitor Protein of cAMP-Dependent Protein Kinase are Regulated by 1,25(OH)₂D₃ and Forskolin\nVitamin D Receptor (VDR) Interactions with Vitamin D₃ Response Elements (VDRE) in the Parathyroid Hormone (PTH) and Osteocalcin Genes are Different\nCoordinate Regulation of Rat Parathyroid Gland Function by Calcium and 1,25- Dihydroxyvitamin D₃\nPhosphorylation Pathways Affect Binding of AP-1 and Vitamin D Receptor to their Combined Response Element in the Promoter Region of Human Osteocalcin Gene\nRapid Actions of Vitamin D Steroids\nTransmembrane Signal Pathways Induced by Calcitriol, Estradiol, Testosterone and Progesterone in Osteoblasts\nNon-Nuclear Actions of 1a,25(OH)₂D₃ and 24R,25(OH)₂D₃ in Mediating Intestinal Calcium Transport: The Use of Analogs to Study Membrane Receptors for Vitamin D Metabolites and to Determine Receptor Ligand Conformational Preferences\nNongenomic Effects of Vitamin D\nBinding of the Occupied Vitamin D Receptor (VDR) to Extra-Nuclear Sites: A Potential Mechanism of Nongenomic Actions of 1a,25(OH)₂D₃\nA Common Mechanism for the Vitamin D Reeeptor Activation and for the Nongenomic Actions of Calcitriol\nThe Calciotropic Hormone 1,25(OH)₂-Vitamin D₃ Stimulates Phospholipase D Activity in Cultured Muscle Cells\nRapid Non-Genomic Effect of 1a,25-Dihydroxyvitamin D₃ on Osteoblast Nuclei\n1a,25-Dìhydroxyvitamin D₃ Induces a Rapid and Sustained Increase in Cytosolic Calcium in Cultured Human Keratinocytes\nAged-Related Changes in the Non-Genomic Response of Intestinal Mammalian Cells to 1,25-Dihydroxy-Vitamin D₃\nVideo Imaging of Intracellular Calcium in Insulinoma Cells: Effects of 1,25(OH)₂D₃\nCellular Signalling Responses Mediated by 1,25(OH)₂-Vitamin D₃ in Rat and Chick Myoblasts\nInvolvement of Adenylate Cyclase System in 1,25-Dihydroxyvitamin D₃ Rapid Stimulation of Ca^{2 +} Uptake by Heart Cells\nSpecific Binding of 1,25-Dihydroxyvitamin D₃ to Rat Colonocyte Basolateral Membranes\nProtein Kinase C Participates in the Signal Transduction Pathway Triggered by 1,25-Dihydroxyvitamin D₃ in Myocytes\nCalbindins D—Function and Gene Regulation: Calcium Transport\nMechanistic Studies on Intestinal Ca^{2 +} Transport\nVitamin D, the Intestinal Plasma Membrane Calcium Pump Gene Expression and the Calbindins\nTissue Specific Calbindin-D_9K Gene Regulation by Calcitriol and Sexual Hormones\nProteins that Bind to the Calbindin-D_9K Promoter: Known Factors and a New Intestinal Factor\nStudies of the Human Calbindin-D_9K Gene\nCalbindins Revisited in the Rat Dental Pulp\nIn Situ Hybridization of Calbindins mRNAs in Rat Ameloblasts\nImmunoreactive Calbindins-D_28K and _9K Mineralization of Rat Epiphyseal Chondrocytes in Culture\nRegulation of Calbindin-D_28K by Parathyroid Hormone in MDBK Cells\nPhosphorylation and Modulation of Calbindin D_28K by Activation of Protein Kinase C (PKC)\nCaco-2 Cells: A Human Intestinal Cell Line for Studying the Biologic Activity of Vitamin D Analogs\nEGF Down Regulates Both Calbindin D_28K and the VDR in MDBK Cells\nDoes Calbindin-D_28K Buffer Intracellular Free Calcium?\nCalbindin-D_28K (CaBP-D_28K) in the Rat Endocrine Pancreas: In Vivo and In Vitro Immunolocalization and its Regulation by Vitamin D₃ Deficiency and 1,25- Dihydroxyvitamin D₃\nEffect of Two Antiestrogens (Tamoxifen and ICI 182780) on Calbindin-D_9K Gene Expression In Vivo in the Rat Uterus, and In Vitro in Primary Cultures of Myometrial Cells\nIdentification of a 9 kDa Calcium-Binding Protein in the Chick as Calbindin-D_9K\nEffect of Antisense Sequences Against Calretinin on WiDr Cells\nIntestinal Absorption of Calcium and Strontium Demonstrate a Similar Response to Calcitriol Treatment\nPhysiological Concentrations of 24,25(OH)₂ Vitamin D₃ Decrease the Intestinal Calcium Uptake in the Atlantic Cod, Gadus Morhua\nEffects of Vitamin D and DL-Buthionine-S, R-Sulfoximine on Intestinal Calcium Absorption\n1,25-(OH)₂D₃ Stimulates Ca²⁺ -Uptake Across the Duodenal Brush Border by at Least Two Independent Mechanisms\nEffect of Heavy Metals on the Level of Calbindin D^28K and the Assimilation of Ca in Chick Duodenum\nApparent Nephron Localization of the 1,25(OH)₂D₃-Stimulated Calmodulin Binding Proteins in the Rat Kidney\nRaised Intestinal Calcium Secretion in the Young Oophorectomised Rat\nValidation of a Simple Test Measuring Intestinal Calcium Absorption Using Strontium as a Marker\nCell Differentiation\nIn Vitro Effects of Potent Vitamin D₃ Analogs on Proliferation and Differentiation of Seven Human Breast Cancer Cell Lines\nTerminal Differentiation of Human Leukemia Cells (HL60) by a Combination of 1,25-Dihydroxyvitamin D₃ and Retinoic Acid (All Trans or 9-Cis)\n1,25-Dihydroxyvitamin D₃ Induces Growth of Thyroid C Cells and Inhibits Calcitonin Secretion In Vitro\nDifferentiation of Human Myelomonocytic Leukemia Cell Lines by Retinoic Acid and Vitamin D₃ Analogs, MC903 and EB1089: Characterization of Cooperative Effects\nEffect of Ascorbate and Calcitriol on HL-60 Promyelocytic Cell Line Proliferation and Differentiation\nEvidence for a Vitamin D Paracrine System Regulating Fetal Pneumocyte Type II Maturation: Local Synthesis of 1,25-(OH)₂D₃ by Lung Fibroblasts\nInhibition of IEC-6 Cell Growth by 1,25(OH)₂D₃: Involvement of TGFß\nInteractions between Vitamin D Derivatives, Retinoids and Granulocyte Macrophage - Colony Stimulating Factor in Leukemic Cell Differentiation\n1,25(OH)₂D₃ and Agents that Increase Intracellular cAMP Synergistically Inhibit the Proliferation of Mouse Fibroblasts\n1a,25-Dihydroxyvitamin D Rapidly Triggers Inhibition of Fibroblast Contraction of Collagen Lattices\nCancer\nImmunology\nDermatology\nNeurosciences\nRenal Osteodystrophy\nBone and Cartilage\nMiscellaneous Biological Actions of Vitamin D Metabolites and Analogs\nAssays for Vitamin D Steroids\nNutrition\nOsteoporosis\nNeonatology and Pregnancy\nGerontology\nOther Basic Science Topics\nOther Clinical Topics\nAuthor Index\nSubject Index\nCell Line Index\nZoo Index