دانلود کتاب Statistical Methods in Toxicology: Proceedings of a Workshop during EUROTOX ’90 Leipzig, Germany, September 12–14, 1990

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Front Matter....Pages N2-IV
Modern Statistical Methods in Toxicology — An overview....Pages 1-4
Statistical Analysis of the Ames Assay....Pages 5-19
Statistical Analysis of the Micronucleus Test with the Fisher-Pitman Permutation Test....Pages 20-24
A Statistical Analysis of HGPRT-Test Data by Means of Computer Simulations....Pages 25-34
Measuring Intra-Assay Agreement for the Ames Salmonella Assay....Pages 35-41
Tabular Overview of Statistical Methods Proposed for the Analysis of Ames Salmonella Assay Data....Pages 42-48
Analyses of Longterm Carcinogenicity Studies....Pages 49-64
Mathematical models for the initiating and promotive action of carcinogens....Pages 65-78
Statistical Problems in Estimating a Threshold in a Dose-Response Model....Pages 79-85
Per-Litter Analyses for Studies of Developmental Toxicity....Pages 86-95
Biometrical Analysis of Strain Differences and Litter Effects....Pages 96-103
Statistical Evaluation of Offspring Parameters in Embryotoxicity Studies....Pages 104-110
General Statistical Principles in Testing of Toxicological Studies....Pages 111-131
Determination of Endpoints in Acute and Chronic Toxicity Tests by Using Generalized Linear Models....Pages 132-138
The Need for Software Validation in Routine Toxicology....Pages 139-149
An Application of Mixed Model Anova for the Assesment of Motor Activity in Rat Behavioural Toxicity Studies....Pages 150-156
Back Matter....Pages 157-161